Search Results - "ROYCE, Simon G"

Electrophysiological, Electroanatomical, and Structural Remodeling of the Atria as Consequences of Sustained Obesity by Mahajan, Rajiv, MD, PhD, Lau, Dennis H., MBBS, PhD, Brooks, Anthony G., PhD, Shipp, Nicholas J., PhD, Manavis, Jim, PhD, Wood, John P.M., D Phil, Finnie, John W., BVSc, PhD, Samuel, Chrishan S., PhD, Royce, Simon G., PhD, Twomey, Darragh J., MBBS, Thanigaimani, Shivshanker, PhD, Kalman, Jonathan M., MBBS, PhD, Sanders, Prashanthan, MBBS, PhD

“…Abstract Background Obesity and atrial fibrillation (AF) are public health issues with significant consequences. Objectives This study sought to delineate the…”
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Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition by Tortorella, Stephanie M, Royce, Simon G, Licciardi, Paul V, Karagiannis, Tom C

“…Sulforaphane, produced by the hydrolytic conversion of glucoraphanin after ingestion of cruciferous vegetables, particularly broccoli and broccoli sprouts, has…”
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A novel Approach for Non-Invasive Lung Imaging and Targeting Lung Immune Cells by Chakraborty, Amlan, Royce, Simon G, Selomulya, Cordelia, Plebanski, Magdalena

“…Despite developments in pulmonary radiotherapy, radiation-induced lung toxicity remains a problem. More sensitive lung imaging able to increase the accuracy of…”
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Serelaxin enhances the therapeutic effects of human amnion epithelial cell‐derived exosomes in experimental models of lung disease by Royce, Simon G., Patel, Krupesh P., Mao, WeiYi, Zhu, Dandan, Lim, Rebecca, Samuel, Chrishan S.

“…Background and Purpose There is growing interest in stem cell‐derived exosomes for their therapeutic and regenerative benefits given their manufacturing and…”
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Obesity results in progressive atrial structural and electrical remodeling: Implications for atrial fibrillation by Abed, Hany S., MBBS, B Pharm, Samuel, Chrishan S., PhD, Lau, Dennis H., MBBS, PhD, Kelly, Darren J., PhD, Royce, Simon G., PhD, Alasady, Muayad, MBChB, Mahajan, Rajiv, MD, Kuklik, Pawel, PhD, Zhang, Yuan, MD, PhD, Brooks, Anthony G., PhD, Nelson, Adam J., MBBS, Worthley, Stephen G., MBBS, PhD, Abhayaratna, Walter P., MBBS, PhD, Kalman, Jonathan M., MBBS, PhD, Wittert, Gary A., MBChB, MD, Sanders, Prashanthan, MBBS, PhD, FHRS

“…Background Obesity is associated with atrial fibrillation (AF); however, the mechanisms by which it induces AF are unknown. Objective To examine the effect of…”
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The regulation of fibrosis in airway remodeling in asthma by Royce, Simon G., Cheng, Victor, Samuel, Chrishan S., Tang, Mimi L.K.

“…► Fibrosis of the airways is an important aspect of asthma pathology. ► Fibrotic remodeling is regulated by asthma associated genes, including relaxin. ► New…”
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Relaxin and fibrosis: Emerging targets, challenges, and future directions by Kanai, Anthony J., Konieczko, Elisa M., Bennett, Robert G., Samuel, Chrishan S., Royce, Simon G.

“…The peptide hormone relaxin is well-known for its anti-fibrotic actions in several organs, particularly from numerous studies conducted in animals. Acting…”
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A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1 by Hossain, Mohammed Akhter, Kocan, Martina, Yao, Song T, Royce, Simon G, Nair, Vinojini B, Siwek, Christopher, Patil, Nitin A, Harrison, Ian P, Rosengren, K Johan, Selemidis, Stavros, Summers, Roger J, Wade, John D, Bathgate, Ross A D, Samuel, Chrishan S

“…Human gene-2 relaxin (H2 relaxin) is a pleiotropic hormone with powerful vasodilatory and anti-fibrotic properties which has led to its clinical evaluation and…”
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Analysis and comparison of anti-RBD neutralizing antibodies from AZD-1222, Sputnik V, Sinopharm and Covaxin vaccines and its relationship with gender among health care workers by Zare, Hamed, Rezapour, Hadis, Fereidouni, Alireza, Nikpour, Saboura, Mahmoudzadeh, Sara, Royce, Simon G, Fereidouni, Mohammad

“…Abstract Background Vaccine efficiency has a significant role in the public perception of vaccination. The current study was designed to evaluate the efficacy…”
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Aerosol Delivery of Palivizumab in a Neonatal Lamb Model of Respiratory Syncytial Virus Infection by Edirisinghe, Hasindu S, Rajapaksa, Anushi E, Royce, Simon G, Sourial, Magdy, Bischof, Robert J, Anderson, Jeremy, Sarila, Gulcan, Nguyen, Cattram D, Mulholland, Kim, Do, Lien Anh Ha, Licciardi, Paul V

“…(1) Background: Palivizumab has been an approved preventative monoclonal antibody for respiratory syncytial virus (RSV) infection for over two decades…”
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Antibacterial activity of aqueous and lipid extracts of five common allergenic pollens by Bashiri, Zahra, Yousefi, Masoud, Royce, Simon G, Fereidouni, Mohammad

“…Background: Different parts of plants are rich sources of bioactive ingredients and have received much attention during recent decades. Objective: The aim of…”
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The intestinal vitamin D receptor in inflammatory bowel disease: inverse correlation with inflammation but no relationship with circulating vitamin D status by Garg, Mayur, Royce, Simon G., Tikellis, Chris, Shallue, Claire, Sluka, Pavel, Wardan, Hady, Hosking, Patrick, Monagle, Shaun, Thomas, Merlin, Lubel, John S., Gibson, Peter R.

“…Background: The intestinal vitamin D receptor (VDR) remains poorly characterized in patients with inflammatory bowel disease (IBD). Methods: Colonoscopic…”
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Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis by Perera, Udari Eshani, Organ, Louise, Royce, Simon G., Samuel, Chrishan S., Derseh, Habtamu B., Dewage, Sasika N. V., Koumoundouros, Emmanuel, Stent, Andrew, Snibson, Kenneth J.

“…Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by excessive deposition of extracellular matrix in the interstitial lung parenchyma,…”
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Lipopolysaccharide does not alter small airway reactivity in mouse lung slices by Donovan, Chantal, Royce, Simon G, Vlahos, Ross, Bourke, Jane E

“…The bacterial endotoxin, lipopolysaccharide (LPS) has been associated with occupational airway diseases with asthma-like symptoms and in acute exacerbations of…”
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Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease by Donovan, Chantal, Bailey, Simon R, Tran, Jenny, Haitsma, Gertruud, Ibrahim, Zaridatul A, Foster, Simon R, Tang, Mimi L K, Royce, Simon G, Bourke, Jane E

“…Rosiglitazone (RGZ), a peroxisome proliferator-activated receptor-γ (PPARγ) ligand, is a novel dilator of small airways in mouse precision cut lung slices…”
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Differential effects of allergen challenge on large and small airway reactivity in mice by Donovan, Chantal, Royce, Simon G, Esposito, James, Tran, Jenny, Ibrahim, Zaridatul Aini, Tang, Mimi L K, Bailey, Simon, Bourke, Jane E

“…The relative contributions of large and small airways to hyperresponsiveness in asthma have yet to be fully assessed. This study used a mouse model of chronic…”
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Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy by Mazarakis, Nadia, Vongsvivut, Jitraporn, Bambery, Keith R., Ververis, Katherine, Tobin, Mark J., Royce, Simon G., Samuel, Chrishan S., Snibson, Kenneth J., Licciardi, Paul V., Karagiannis, Tom C.

“…The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established model for investigating pre-clinical therapies for chronic allergic…”
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Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease by Royce, Simon G, Tominaga, Anna M, Shen, Matthew, Patel, Krupesh P, Huuskes, Brooke M, Lim, Rebecca, Ricardo, Sharon D, Samuel, Chrishan S

“…Current asthma therapies primarily target airway inflammation (AI) and suppress episodes of airway hyperresponsiveness (AHR) but fail to treat airway…”
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Comparison of Airway Remodeling in Acute, Subacute, and Chronic Models of Allergic Airways Disease by Locke, Natasha R, Royce, Simon G, Wainewright, Jacquetta S, Samuel, Chrishan S, Tang, Mimi L

“…The relationship between airway inflammation and structural changes of airway remodeling, and their relative effects on airway function, are poorly understood…”
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Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease by Royce, Simon G., Shen, Matthew, Patel, Krupesh P., Huuskes, Brooke M., Ricardo, Sharon D., Samuel, Chrishan S.

“…This study determined if the anti-fibrotic drug, serelaxin (RLN), could augment human bone marrow-derived mesenchymal stem cell (MSC)-mediated reversal of…”
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