Search Results - "ROWLEY, Donald A"

Relapse or Eradication of Cancer Is Predicted by Peptide-Major Histocompatibility Complex Affinity by Engels, Boris, Engelhard, Victor H., Sidney, John, Sette, Alessandro, Binder, David C., Liu, Rebecca B., Kranz, David M., Meredith, Stephen C., Rowley, Donald A., Schreiber, Hans

“…Cancers often relapse after adoptive therapy, even though specific T cells kill cells from the same cancer efficiently in vitro. We found that tumor…”
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Inflammation as a tumor promoter in cancer induction by Philip, Mary, Rowley, Donald A., Schreiber, Hans

“…Opposing effects of inflammation on cancer have been described. Acute inflammation usually counteracts cancer development, while chronic inflammation promotes…”
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Densely Granulated Murine NK Cells Eradicate Large Solid Tumors by LIU, Rebecca B, ENGELS, Boris, JABRI, Bana, SCHREIBER, Hans, ARINA, Ainhoa, SCHREIBER, Karin, HYJEK, Elizabeth, SCHIETINGER, Andrea, BINDER, David C, BUTZ, Eric, KRAUSZ, Thomas, ROWLEY, Donald A

“…Natural killer (NK) cells inhibit early stages of tumor formation, recurrence, and metastasis. Here, we show that NK cells can also eradicate large solid…”
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The role of stroma in immune recognition and destruction of well-established solid tumors by Yu, Ping, Rowley, Donald A, Fu, Yang-Xin, Schreiber, Hans

“…Well-established solid tumors (at least 14 days old and >1 cm in average diameter) are extremely difficult to eradicate immunologically in mice. Most cancer…”
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A systematic analysis of experimental immunotherapies on tumors differing in size and duration of growth by Wen, Frank T., Thisted, Ronald A., Rowley, Donald A., Schreiber, Hans

“…We conducted a systematic analysis to determine the reason for the apparent disparity of success of immunotherapy between clinical and experimental cancers. To…”
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Increasing Tumor Antigen Expression Overcomes “Ignorance” to Solid Tumors via Crosspresentation by Bone Marrow-Derived Stromal Cells by Spiotto, Michael T., Yu, Ping, Rowley, Donald A., Nishimura, Michael I., Meredith, Stephen C., Gajewski, Thomas F., Fu, Yang-Xin, Schreiber, Hans

“…To explain why solid cancers grow or are rejected, we examined how the tumor stroma affected the level of antigen expression necessary to induce an immune…”
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Targeting stroma to treat cancers by Engels, Boris, Rowley, Donald A, Schreiber, Hans

“…Abstract All cancers depend on stroma for support of growth. Leukemias, solid tumors, cancer cells causing effusions, metastases as well as micro-disseminated…”
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IFN-gamma- and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers by Zhang, Bin, Karrison, Theodore, Rowley, Donald A, Schreiber, Hans

“…Tumors elicit antitumor immune responses, but over time they evolve and can escape immune control through various mechanisms, including the loss of the antigen…”
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Awakening Immunity by Schreiber, Hans, Rowley, Donald A.

“…The elimination of specific stromal cells allows the immune system to suppress the growth of solid malignant tumors. Cancer cells are embedded in stroma, the…”
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Induced sensitization of tumor stroma leads to eradication of established cancer by T cells by Zhang, Bin, Bowerman, Natalie A, Salama, Joseph K, Schmidt, Hank, Spiotto, Michael T, Schietinger, Andrea, Yu, Ping, Fu, Yang-Xin, Weichselbaum, Ralph R, Rowley, Donald A, Kranz, David M, Schreiber, Hans

“…Targeting cancer cells, as well as the nonmalignant stromal cells cross-presenting the tumor antigen (Ag), can lead to the complete destruction of…”
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Bystander elimination of antigen loss variants in established tumors by Spiotto, Michael T, Rowley, Donald A, Schreiber, Hans

“…Cancers express antigens that are targets for specific cytotoxic T lymphocytes (CTLs). However, cancer cells are genetically unstable. Consequently,…”
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c‐kit+ FcR+ myelocytes are increased in cancer and prevent the proliferation of fully cytolytic T cells in the presence of immune serum by Beck, Christian, Schreiber, Karin, Schreiber, Hans, Rowley, Donald A.

“…Immunogenic cancers induce both IgG antibodies and CD8+ cytotoxic T lymphocytes (CTL). Rejection of almost all immunogenic tumors depends ultimately on CTL…”
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Synergy Between T-Cell Immunity and Inhibition of Paracrine Stimulation Causes Tumor Rejection by Seung, L P, Rowley, D A, Dubey, P, Schreiber, H

“…During tumor progression, variants may arise that grow more vigorously. The fate of such variants depends upon the balance between aggressiveness of the…”
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The road to the discovery of dendritic cells, a tribute to Ralph Steinman by Rowley, Donald A., Fitch, Frank W.

“…While it was known by the 1960s that lymphocytes mediated adaptive immunity, it was unknown how antigens stimulated lymphocytes. Between 1967 and 1973, we…”
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Equilibrium between Host and Cancer Caused by Effector T Cells Killing Tumor Stroma by BIN ZHANG, YI ZHANG, BOWERMAN, Natalie A, SCHIETINGER, Andrea, FU, Yang-Xin, KRANZ, David M, ROWLEY, Donald A, SCHREIBER, Hans

“…The growth of solid tumors depends on tumor stroma. A single adoptive transfer of CD8(+) CTLs that recognize tumor antigen-loaded stromal cells, but not the…”
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Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer by Binder, David C, Engels, Boris, Arina, Ainhoa, Yu, Ping, Slauch, James M, Fu, Yang-Xin, Karrison, Theodore, Burnette, Byron, Idel, Christian, Zhao, Ming, Hoffman, Robert M, Munn, David H, Rowley, Donald A, Schreiber, Hans

“…Immunogenic tumors grow progressively even when heavily infiltrated by CD8(+) T cells. We investigated how to rescue CD8(+) T cell function in long-established…”
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Spleen Cells from Young but Not Old Immunized Mice Eradicate Large Established Cancers by SCHREIBER, Karin, ARINA, Ainhoa, ENGELS, Boris, SPIOTTO, Michael T, SIDNEY, John, SETTE, Alessandro, KARRISON, Theodore G, WEICHSELBAUM, Ralph R, ROWLEY, Donald A, SCHREIBER, Hans

“…Solid tumors that have grown two weeks or longer in mice and have diameters larger than 1 cm are histologically indistinguishable from autochthonous human…”
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Targeting mutations predictably by Schreiber, Hans, Rowley, Janet D., Rowley, Donald A.

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Cancer. Quo vadis, specificity? by Schreiber, Hans, Rowley, Donald A

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Cancer immunotherapy and preclinical studies: why we are not wasting our time with animal experiments by Schreiber, Karin, Rowley, Donald A, Riethmüller, Gert, Schreiber, Hans

“…Experimental research on the immune response to transplanted tumors has led to pioneering discoveries that laid many of the foundations for the current field…”
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