Search Results - "ROWE, JENNY"

1452 NCG-X is a triple immunodeficient mouse capable of being immune humanized without irradiation for use in immunotherapy preclinical research by Rowe, Jenny, Bronson, Steven, Eberle, Christoph, Mihalek, Robert, Festin, Stephen

“…BackgroundThe NCG is a triple immunodeficient mouse that lacks mouse T cells, B cells and NK cells. This makes it permissible to engraftment by human…”
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1449 NCG-M is a triple immunodeficient mouse with increased reconstitution of human myeloid cell populations for use in immunotherapy preclinical research by Bronson, Steven, Rowe, Jenny, Eberle, Christoph, Mihalek, Robert, Fiore, Ann, Festin, Stephen

“…BackgroundImmune humanized mice are immunodeficient mice that have been engrafted with human hematopoietic stem cells or peripheral blood mononuclear cells…”
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Genetic Analysis of Varicella-Zoster Virus ORF0 to ORF4 by Use of a Novel Luciferase Bacterial Artificial Chromosome System by ZHEN ZHANG, ROWE, Jenny, WEIJIA WANG, SOMMER, Marvin, ARVIN, Ann, MOFFAT, Jennifer, HUA ZHU

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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199 Enhanced immune responses in human breast and colon cancer following checkpoint therapy in a CD34+ stem cell humanized NCG (HuCD34NCG) mouse model by Eberle, Christoph, Rowe, Jenny, Fiore, Ann, Mihalek, Robert, Festin, Stephen

“…BackgroundBreast and colon cancer rank second and third, respectively, in world-wide prevalence of malignancies and present a large unmet medical need. The…”
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At the Heart of Justice: the Library at the new Supreme Court of the United Kingdom by Rowe, Jenny

“…The new Supreme Court of the United Kingdom, which heard its first case in October 2009, sits at the apex of the UK's justice systems. Located in the…”
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Abstract 5634: The single mouse trial format predicts the sensitivity towards checkpoint inhibitor treatment in NSCLC PDX models in HuCD34NCG/CRL mice, an innovative triple immune deficient mouse strain by Schüler, Julia, Rowe, Jenny, Oswald, Eva, Festin, Stephen

“…Abstract Immunotherapy is revolutionizing cancer treatment. As a consequence, there is an urgent need for predictive preclinical models to support compound…”
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Abstract 2770: Evaluation of tumor growth and baseline leukocyte infiltration in Charles River C57BL/6 and Balb/c mice engrafted with MC38, B16F10, RENCA and EMT6 cells by Eberle, Christoph S., Rowe, Jenny, Fiore, Ann, Mihalek, Robert, Festin, Stephen

“…Abstract Background: In vivo syngeneic models continue to be an important tool in cancer biology research. Charles River C57BL/6 and Balb/c mice, two…”
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Abstract 4191: Delayed onset of GvHD in PBMC humanized NCG-B2m KO mice provides an enhanced model for oncology studies by Bronson, Steven, Harris, David, Avrutskaya, Anya, Eberle, Christoph, Rowe, Jenny

“…Abstract Humanized mice are specialized animal models incorporating components of the human immune system. These models are valuable tools for assessing the…”
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Abstract 38: PBMC donor selection affects engraftment rates and onset of graft versus host disease in humanized NCG mice for use in cancer studies by Bronson, Steven, Rowe, Jenny, Eberle, Christoph, Festin, Stephen

“…Abstract Preclinical studies examining tumor biology and immunity are limited by differences between the mouse and human immune systems. Humanized mouse models…”
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Abstract 5625: Evaluation of in vivo anti-tumor response of solid tumors in a novel immune cell-humanized NOD-Prkdcem26Cd52Il2rgem26Cd22/NjuCrl mouse model by ROWE, JENNY, Eberle, Christoph, Reap, Elizabeth, Fiore, Ann, Avrutskaya, Anya, de Marval, Paula Miliani, Mihalek, Robert, Festin, Stephen

“…Abstract Background: Checkpoint blockade inhibitors targeting PD-1 and CTLA-4 pathways are clinically approved therapies for multiple cancer types. The…”
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Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia by Zhang, Lu, Cai, Tianyu, Lin, Xiaoyu, Huang, Xiaoli, Bui, Mai H, Plotnik, Joshua P, Bellin, Richard J, Faivre, Emily J, Kuruvilla, Vinitha M, Lam, Lloyd T, Lu, Xin, Zha, Zheng, Feng, Weiguo, Hessler, Paul, Uziel, Tamar, Zhang, Qi, Cavazos, Antonio, Han, Lina, Ferguson, Debra C, Mehta, Gaurav, Shanmugavelandy, Sriram S, Magoc, Terrance J, Rowe, Jenny, Goodwin, Neal C, Dorritie, Kathleen A, Boyiadzis, Michael, Albert, Daniel H, McDaniel, Keith F, Kati, Warren M, Konopleva, Marina, Shen, Yu

“…Dual bromodomain BET inhibitors that bind with similar affinities to the first and second bromodomains across BRD2, BRD3, BRD4, and BRDT have displayed modest…”
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Abstract 39: Assessment of a novel method using adult healthy donor mobilized human CD34+hematopoietic stem cells in NCG mice for use in tumor modeling by Rowe, Jenny, Bronson, Steven, Eberle, Christoph, Fiore, Ann, Mihalek, Bob, Festin, Stephen

“…Abstract Checkpoint inhibitors including anti-PD-1/PD-L1 are a type of immunotherapy that have become the standard of care for cancer patients. Continual focus…”
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SARS-CoV-2 Omicron (B.1.1.529) shows minimal neurotropism in a double-humanized mouse model by Alves, Rubens Prince dos Santos, Wang, Ying-Ting, Mikulski, Zbigniew, McArdle, Sara, Shafee, Norazizah, Valentine, Kristen M., Miller, Robyn, Verma, Shailendra Kumar, Batiz, Fernanda Ana Sosa, Maule, Erin, Nguyen, Michael N., Timis, Julia, Mann, Colin, Zandonatti, Michelle, Alarcon, Suzie, Rowe, Jenny, Kronenberg, Mitchell, Weiskopf, Daniela, Sette, Alessandro, Hastie, Kathryn, Saphire, Erica Ollmann, Festin, Stephen, Kim, Kenneth, Shresta, Sujan

“…Although severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initially infects the respiratory tract, it also directly or indirectly affects other…”
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Non-Clinical Cell Therapy Development Using the NCG Mouse Model as a Test System by Smutova, Viktorija, Pará, Camila, Foret, Morgan K., Bennamoune, Nehla, Hung, Selly, Spickler, Catherine, Riffon, Renee, Rowe, Jenny, Festin, Stephen, Authier, Simon

“…The NCG triple immunodeficient mice on a NOD/Nju background lack functional/mature T, B, and NK cells, and have reduced macrophage and dendritic cell function…”
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Abstract 1647: Assessment of a novel tumor model using adult patient mobilized human CD34+ hematopoietic stem cells in NCG mice by Rowe, Jenny, Eberle, Christoph, Fiore, Ann, Mihalek, Robert, Schoen, Brianna, Festin, Stephen

“…Abstract Background: Inhibitors of the PD-1/PD-L1 checkpoint pathway were among the first FDA approved immunotherapies and are now among the standard of care…”
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Abstract 4186: Development of an orthotopic A549 lung carcinoma model in CD34+ humanized NCG mice and response to treatment with paclitaxel and pembrolizumab by Avrutskaya, Anya, Rainbolt, Elizabeth, John, Bincy, Clouse, Cara, Stackhouse, Murray, Currie, Christopher, Scatigno, Sydney, Bronson, Steven, Rowe, Jenny, Hall, Chassidy, Harris, David P.

“…Abstract Translational in vivo models are needed to expedite the discovery of new treatments for lung cancer. One such approach is the use of humanized mouse…”
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Humanized NOG mice as a model for tuberculosis vaccine‐induced immunity: a comparative analysis with the mouse and guinea pig models of tuberculosis by Grover, Ajay, Troy, Amber, Rowe, Jenny, Troudt, JoLynn M., Creissen, Elizabeth, McLean, Jennifer, Banerjee, Prabal, Feuer, Gerold, Izzo, Angelo A.

“…Summary The humanized mouse model has been developed as a model to identify and characterize human immune responses to human pathogens and has been used to…”
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Abstract 1150: Acute myeloid leukemia human/mouse co-clinical trial feasibility study optimized in human transgenic IL-3/GMCSF NOD/Shi- scid -IL2rγ null mice by Goodwin, Neal C., Albert, Daniel H., Davies, Angela M., Rowe, Jenny, Feuer, Gerold, Boyiadzis, Michael, Dorritie, Kathleen A., Mancini, Maria, Gandour-Edwards, Regina, Kati, Warren M., McKee, Mark D., McDaniel, Keith F., Frost, David J.

“…Abstract Acute myeloid leukemia (AML) co-clinical modeling has been optimized with peripheral blood mononuclear cells (PBMCs) collected from low volume (14 mL)…”
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Co-clinical Modeling of the Activity of the BET Inhibitor Mivebresib (ABBV-075) in AML by ALBERT, DANIEL H., GOODWIN, NEAL C., DAVIES, ANGELA M., ROWE, JENNY, FEUER, GEROLD, BOYIADZIS, MICHAEL, DORRITIE, KATHLEEN A., MANCINI, MARIA, GANDOUR-EDWARDS, REGINA, JONAS, BRIAN A., BORTHAKUR, GAUTAM, ALDOSS, IBRAHIM, RIZZIERI, DAVID A., ODENIKE, OLATOYOSI, PREBET, THOMAS, SINGH, SANJANA, POPOVIC, RELJA, SHEN, YU, MCDANIEL, KEITH F., KATI, WARREN M., MODI, DIMPLE A., MOTWANI, MONICA, WOLFF, JOHANNES E., FROST, DAVID J.

“…BACKGROUND/AIMThe therapeutic potential of bromodomain and extra-terminal motif (BET) inhibitors in hematological cancers has been well established in…”
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Where Texts and Children Meet by Bearne, Eve, Watson, Victor

“…It is impossible to reflect upon children's books without considering the children who read them. Where Texts and Children Meet explores the ways in which…”
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