Search Results - "ROVERO, Paolo"

Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation by Ledwoń, Patrycja, Papini, Anna Maria, Rovero, Paolo, Latajka, Rafal

“…Collagen fibres degradation is a complex process involving a variety of enzymes. Fibrillar collagens, namely type I, II, and III, are the most widely spread…”
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Peptide-Functionalized Silk Fibers as a Platform to Stabilize Gelatin for Use in Ingestible Devices by Valentini, Luca, Pacini, Lorenzo, Errante, Fosca, Morchio, Cecilia, Sanna, Beatrice, Rovero, Paolo, Morabito, Antonino

“…The combination of pharmacologic and endoscopic therapies is the gold standard for treating intestinal failures. The possibility of chemical solubility in…”
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Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy by Errante, Fosca, Ledwoń, Patrycja, Latajka, Rafal, Rovero, Paolo, Papini, Anna Maria

“…Among the many aspects that contribute to the wellness of each individual, healthy and younger-looking skin play a relevant role, as clearly shown by the…”
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Porcine Relaxin but Not Serelaxin Shows Residual Bioactivity after In Vitro Simulated Intestinal Digestion-Clues for the Development of New Relaxin Peptide Agonists Suitable for Oral Delivery by Pacini, Lorenzo, D'Ercole, Annunziata, Papini, Anna Maria, Bani, Daniele, Nistri, Silvia, Rovero, Paolo

“…Despite human recombinant H2 relaxin or serelaxin holding promise as a cardiovascular drug, its actual efficacy in chronic treatment of heart failure patients…”
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First studies on tumor associated carbonic anhydrases IX and XII monoclonal antibodies conjugated to small molecule inhibitors by Testa, Chiara, Papini, Anna Maria, Zeidler, Reinhard, Vullo, Daniela, Carta, Fabrizio, Supuran, Claudiu T, Rovero, Paolo

“…We report for the first time Antibody-Drug-Conjugates (ADCs) containing human (h) Carbonic Anhydrase (CA; EC 4.2.1.1) directed Monoclonal Antibodies (MAbs)…”
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A peptide-based anti-Adalimumab antibody assay to monitor immune response to biologics treatment in juvenile idiopathic arthritis and childhood chronic non-infectious uveitis by Rusche, Hendrik, Marrani, Edoardo, Real-Fernandez, Feliciana, Ponti, Roberta, Terzani, Francesco, Maccora, Ilaria, Monasson, Olivier, Mastrolia, Maria Vincenza, Peroni, Elisa, Pagnini, Ilaria, Cimaz, Rolando, Papini, Anna Maria, Simonini, Gabriele, Rovero, Paolo

“…Immune response to biologics treatment, while widely reported, yet fails to correlate with clinical outcomes and assay to assay comparison is often not…”
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Biomaterial Inks from Peptide-Functionalized Silk Fibers for 3D Printing of Futuristic Wound-Healing and Sensing Materials by Ceccarini, Maria Rachele, Palazzi, Valentina, Salvati, Raffaele, Chiesa, Irene, De Maria, Carmelo, Bonafoni, Stefania, Mezzanotte, Paolo, Codini, Michela, Pacini, Lorenzo, Errante, Fosca, Rovero, Paolo, Morabito, Antonino, Beccari, Tommaso, Roselli, Luca, Valentini, Luca

“…This study illustrates the sensing and wound healing properties of silk fibroin in combination with peptide patterns, with an emphasis on the printability of…”
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Triazole-Modified Peptidomimetics: An Opportunity for Drug Discovery and Development by Staśkiewicz, Agnieszka, Ledwoń, Patrycja, Rovero, Paolo, Papini, Anna Maria, Latajka, Rafal

“…Peptidomimetics play a fundamental role in drug design due to their preferential properties regarding natural peptides. In particular, compounds possessing…”
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SARS-CoV-2 inhibitory activity of a short peptide derived from internal fusion peptide of S2 subunit of spike glycoprotein by Stincarelli, Maria Alfreda, Quagliata, Michael, Di Santo, Andrea, Pacini, Lorenzo, Fernandez, Feliciana Real, Arvia, Rosaria, Rinaldi, Silvia, Papini, Anna Maria, Rovero, Paolo, Giannecchini, Simone

“…•Peptides designed on internal fusion peptide region of S2 subunit of Spike SARS-CoV-2.•High inhibitory activity of a short PN19 peptide from internal fusion…”
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Fine Mapping of Glutamate Decarboxylase 65 Epitopes Reveals Dependency on Hydrophobic Amino Acids for Specific Interactions by Valdarnini, Niccolò, Holm, Bettina, Hansen, Paul, Rovero, Paolo, Houen, Gunnar, Trier, Nicole

“…Characterization of multiple antibody epitopes has revealed the necessity of specific groups of amino acid residues for reactivity. This applies to the…”
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Tripeptides conjugated with thiosemicarbazones: new inhibitors of tyrosinase for cosmeceutical use by Ledwoń, Patrycja, Goldeman, Waldemar, Hałdys, Katarzyna, Jewgiński, Michał, Calamai, Greta, Rossowska, Joanna, Papini, Anna Maria, Rovero, Paolo, Latajka, Rafał

“…The development of skin-care products is recently growing. Cosmetic formulas containing active ingredients with proven efficacy, namely cosmeceuticals, are…”
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Peptide Antibody Reactivity to Homologous Regions in Glutamate Decarboxylase Isoforms and Coxsackievirus B4 P2C by Trier, Nicole Hartwig, Valdarnini, Niccolo, Fanelli, Ilaria, Rovero, Paolo, Hansen, Paul Robert, Schafer-Nielsen, Claus, Ciplys, Evaldas, Slibinskas, Rimantas, Pociot, Flemming, Friis, Tina, Houen, Gunnar

“…Two isoforms of the glutamate decarboxylase (GAD) enzyme exist, GAD65 and GAD67, which are associated with type 1 diabetes (T1D) and stiff-person syndrome…”
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An Optimised Di-Boronate-ChemMatrix Affinity Chromatography to Trap Deoxyfructosylated Peptides as Biomarkers of Glycation by Kijewska, Monika, Nuti, Francesca, Wierzbicka, Magdalena, Waliczek, Mateusz, Ledwoń, Patrycja, Staśkiewicz, Agnieszka, Real-Fernandez, Feliciana, Sabatino, Giuseppina, Rovero, Paolo, Stefanowicz, Piotr, Szewczuk, Zbigniew, Papini, Anna Maria

“…We report herein a novel ChemMatrix Rink resin functionalised with two phenylboronate (PhB) moieties linked on the -α and -ε amino functions of a lysine…”
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Design, synthesis, conformational analysis, and biological activity of Cα1-to-Cα6 1,4- and 4,1-disubstituted 1H-[1,2,3]triazol-1-yl-bridged oxytocin analogues by Nuti, Francesca, Larregola, Maud, Staśkiewicz, Agnieszka, Retzl, Bernhard, Tomašević, Nataša, Macchia, Lorenzo, Street, Maria E, Jewgiński, Michał, Lequin, Olivier, Latajka, Rafal, Rovero, Paolo, Gruber, Christian W, Chorev, Michael, Papini, Anna Maria

“…Oxytocin (OT) is a neurohypophyseal peptide hormone containing a disulphide-bridged pseudocyclic conformation. The biomedical use of OT peptides is limited…”
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Synthesis and Conformational Analysis of a Cyclic Peptide Obtained via i to i+4 Intramolecular Side-Chain to Side-Chain Azide−Alkyne 1,3-Dipolar Cycloaddition by Cantel, Sonia, Le Chevalier Isaad, Alexandra, Scrima, Mario, Levy, Jay J, DiMarchi, Richard D, Rovero, Paolo, Halperin, Jose A, D’Ursi, Anna Maria, Papini, Anna Maria, Chorev, Michael

“…Intramolecular side-chain to side-chain cyclization is an established approach to achieve stabilization of specific conformations and a recognized strategy to…”
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Di-(2-ethylhexyl) phthalate and autism spectrum disorders by Testa, Chiara, Nuti, Francesca, Hayek, Joussef, De Felice, Claudio, Chelli, Mario, Rovero, Paolo, Latini, Giuseppe, Papini, Anna Maria

“…ASDs (autism spectrum disorders) are a complex group of neurodevelopment disorders, still poorly understood, steadily rising in frequency and treatment…”
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Synthetic short-chain peptide analogues of H1 relaxin lack affinity for the RXFP1 receptor and relaxin-like bioactivity. Clues to a better understanding of relaxin agonist design by D'Ercole, Annunziata, Nistri, Silvia, Pacini, Lorenzo, Carotenuto, Alfonso, Santoro, Federica, Papini, Anna Maria, Bathgate, Ross A. D., Bani, Daniele, Rovero, Paolo

“…The peptide hormone relaxin (RLX), also available as clinical-grade recombinant protein (serelaxin), holds great promise as a cardiovascular and anti-fibrotic…”
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A SARS-CoV-2 Spike Receptor Binding Motif Peptide Induces Anti-Spike Antibodies in Mice andIs Recognized by COVID-19 Patients by Pratesi, Federico, Errante, Fosca, Pacini, Lorenzo, Peña-Moreno, Irina Charlot, Quiceno, Sebastian, Carotenuto, Alfonso, Balam, Saidou, Konaté, Drissa, Diakité, Mahamadou M, Arévalo-Herrera, Myriam, Kajava, Andrey V, Rovero, Paolo, Corradin, Giampietro, Migliorini, Paola, Papini, Anna M, Herrera, Sócrates

“…The currently devastating pandemic of severe acute respiratory syndrome known as coronavirus disease 2019 or COVID-19 is caused by the coronavirus SARS-CoV-2…”
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The Clinical Evidence-Based Paradigm of Topical Anti-Aging Skincare Formulations Enriched with Bio-Active Peptide SA1-III (KP1) as Collagen Modulator: From Bench to Bedside by Rovero, Paolo, Malgapo, Dennis Malvin Hernandez, Sparavigna, Adele, Beilin, Ghislaine, Wong, Vincent, Lao, Ma Purita

“…A substantial reduction in the amount and quality of collagen leads to age-related deterioration of the elasticity and firmness of the skin. In recent years,…”
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Seroreactivity of the Severe Acute Respiratory Syndrome Coronavirus 2 Recombinant S Protein, Receptor-Binding Domain, and Its Receptor-Binding Motif in COVID-19 Patients and Their Cross-Reactivity With Pre-COVID-19 Samples From Malaria-Endemic Areas by Traoré, Abdouramane, Guindo, Merepen A, Konaté, Drissa, Traoré, Bourama, Diakité, Seidina A, Kanté, Salimata, Dembélé, Assitan, Cissé, Abdourhamane, Incandela, Nathan C, Kodio, Mamoudou, Coulibaly, Yaya I, Faye, Ousmane, Kajava, Andrey V, Pratesi, Federico, Migliorini, Paola, Papini, Anna Maria, Pacini, Lorenzo, Rovero, Paolo, Errante, Fosca, Diakité, Mahamadou, Arevalo-Herrera, Myriam, Herrera, Socrates, Corradin, Giampietro, Balam, Saidou

“…Despite the global interest and the unprecedented number of scientific studies triggered by the COVID-19 pandemic, few data are available from developing and…”
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