Search Results - "ROUSSEL, Patrick"

Optimization of 6,6-dimethyl pyrrolo[3,4- c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing by Brasca, Maria Gabriella, Albanese, Clara, Alzani, Rachele, Amici, Raffaella, Avanzi, Nilla, Ballinari, Dario, Bischoff, James, Borghi, Daniela, Casale, Elena, Croci, Valter, Fiorentini, Francesco, Isacchi, Antonella, Mercurio, Ciro, Nesi, Marcella, Orsini, Paolo, Pastori, Wilma, Pesenti, Enrico, Pevarello, Paolo, Roussel, Patrick, Varasi, Mario, Volpi, Daniele, Vulpetti, Anna, Ciomei, Marina

“…We describe the synthesis of compounds with interesting biochemical and cellular characteristics. Optimization of the physico-chemical properties led to the…”
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The Natural Diyne-Furan Fatty Acid EV-086 Is an Inhibitor of Fungal Delta-9 Fatty Acid Desaturation with Efficacy in a Model of Skin Dermatophytosis by KNECHTLE, Philipp, DIEFENBACHER, Melanie, GHANNOUM, Mahmoud A, SCHNEITER, Roger, SORENSEN, Alexandra S, GREVE, Katrine B. V, BRIANZA, Federico, FOLLY, Christophe, HEIDER, Harald, LONE, Museer A, LONG, Lisa, MEYER, Jean-Philippe, ROUSSEL, Patrick

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Crystallographic Analysis of Bacterial Signal Peptidase in Ternary Complex with Arylomycin A2 and a β-Sultam Inhibitor by Luo, Chuanyun, Roussel, Patrick, Dreier, Jürg, Page, Malcolm G.P, Paetzel, Mark

“…Bacterial type I signal peptidase (SPase I), an essential membrane-bound endopeptidase with a unique Ser/Lys dyad mechanism, is being investigated as a…”
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Probabilistic Tsunami Hazard Assessment for a Site in Eastern Canada by Kulkarni, Vikram, Arcos, Maria E. M., Alcinov, Trajce, Lavine, Alexis, Youngs, Robert, Roussel, Patrick, Mullin, Derek

“…Unlike probabilistic seismic hazard analysis (PSHA), there is not a well-established methodology for probabilistic tsunami hazard analysis (PTHA). The PTHA…”
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Identification of Potent Pyrazolo[4,3-h]quinazoline-3-carboxamides as Multi-Cyclin-Dependent Kinase Inhibitors by Traquandi, Gabriella, Ciomei, Marina, Ballinari, Dario, Casale, Elena, Colombo, Nicoletta, Croci, Valter, Fiorentini, Francesco, Isacchi, Antonella, Longo, Antonio, Mercurio, Ciro, Panzeri, Achille, Pastori, Wilma, Pevarello, Paolo, Volpi, Daniele, Roussel, Patrick, Vulpetti, Anna, Brasca, Maria Gabriella

“…Abnormal proliferation mediated by disruption of the mechanisms that keep the cell cycle under control is a hallmark of virtually all cancer cells. Compounds…”
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Crystallographic Analysis of Bacterial Signal Peptidase in Ternary Complex with Arylomycin A 2 and a β-Sultam Inhibitor by Luo, Chuanyun, Roussel, Patrick, Dreier, Jürg, Page, Malcolm G.P., Paetzel, Mark

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Crystallographic Analysis of Bacterial Signal Peptidase in Ternary Complex with Arylomycin A2 and a b-Sultam Inhibitor by Luo, Chuanyun, Dreier, Patrick Roussel Jrg, Page, Malcolm G P, Paetzel, Mark

“…Bacterial type I signal peptidase (SPase I), an essential membrane-bound endopeptidase with a unique Ser/Lys dyad mechanism, is being investigated as a…”
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Investigation of the species-dependent in vitro metabolism of BAL30630 by stable isotope labeling and isotope exchange experiments analyzed by capillary liquid chromatography coupled to mass spectrometry by Wind, Mathias, Grunwald, Helge, Gebhardt, Klaus, Illig, Klaus, Spickermann, Jochen, Nuoffer, Claude, Roussel, Patrick, Klauer, Dominique, Fullhardt, Pascal, Schmitt-Hoffmann, Anne, Schleimer, Michael

“…The in vitro metabolic profile of BAL30630, an antifungal piperazine propanol derivative, which inhibits the 1,3-beta- d-glucansynthase, was investigated by…”
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Solid-Phase Synthesis of 2,4,6-Triaminopyrimidines by Guillier, Fabrice, Roussel, Patrick, Moser, Heinz, Kane, Peter, Bradley, Mark

“…A library of various 2,4,6‐triaminopyrimidines was prepared by a solid‐phase approach with a ring‐activation/amination process (see scheme). Regio‐ and…”
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6-Substituted Pyrrolo[3,4-c]pyrazoles: An Improved Class of CDK2 Inhibitors by Brasca, Maria Gabriella, Albanese, Clara, Amici, Raffaella, Ballinari, Dario, Corti, Luca, Croci, Valter, Fancelli, Daniele, Fiorentini, Francesco, Nesi, Marcella, Orsini, Paolo, Orzi, Fabrizio, Pastori, Wilma, Perrone, Ettore, Pesenti, Enrico, Pevarello, Paolo, Riccardi-Sirtori, Federico, Roletto, Fulvia, Roussel, Patrick, Varasi, Mario, Vulpetti, Anna, Mercurio, Ciro

“…We have recently reported a new class of CDK2/cyclin A inhibitors based on a bicyclic tetrahydropyrrolo[3,4‐c]pyrazole scaffold. The introduction of small…”
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Inhibition of the tissue factor/factor VIIa complex — Lead optimisation using combinatorial chemistry by Roussel, Patrick, Bradley, Mark, Kane, Peter, Bailey, Christine, Arnold, Ruth, Cross, Andrew

“…Following a high throughput screen (HTS) for the inhibition of the tissue factor/factor VIIa complex and the identification of a number of original hits a lead…”
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A serious game for gait rehabilitation with the Lokomat by Michaud, Benjamin, Cherni, Yosra, Begon, Mickael, Girardin-Vignola, Genevieve, Roussel, Patrick

“…Motivation and commitment are major factors in the effectiveness of a rehabilitation treatment. To increase the level of interest of disabled children in their…”
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A linker for amidines in solid phase synthesis by Roussel, Patrick, Bradley, Mark, Matthews, Ian, Kane, Peter

“…A range of linkers for the important amidine pharmacophore, cleavable using acid or light have been developed for use in library synthesis. The utility of…”
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Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators by Thor, Markus, Beierlein, Katarina, Dykes, Graeme, Gustavsson, Anna-Lena, Heidrich, Jessica, Jendeberg, Lena, Lindqvist, Bengt, Pegurier, Cecile, Roussel, Patrick, Slater, Martin, Svensson, Stefan, Sydow-Bäckman, Mona, Thornström, Ulla, Uppenberg, Jonas

“…A series of 5-substituted 2-benzoylaminobenzoic acids has been synthesized and assayed for PPARα/γ activity. Both dual activators and selective PPARγ agonists…”
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Anthropology and freedom in Kant's moral philosophy: Saving Kant from Schleiermacher's dilemma by Frierson, Patrick Roussel

“…Both neokantian moral theorists and Kant scholars have begun to incorporate Kant's moral anthropology. The result has been kantian moral theory that pays…”
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Synthesis and antiaggregant properties of Stabilized analogues of polyunsaturated fatty acid metabolites by Hachem, Ali, Roussel, Patrick, Ménager, Eric, Grée, Danielle, Le Floc'h, Yves, Grée, René, Cerletti, Chiara, Rolland, Yves, Simonet, Serge, Verbeuren, Tony

“…New aromatic and heteroaromatic analogues of polyunsaturated fatty acid metabolites have been prepared using short and versatile strategies. Preliminary…”
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Anthropology and freedom in Kant's moral philosophy: Saving Kant from Schleiermacher's dilemma by Frierson, Patrick Roussel

“…Both neokantian moral theorists and Kant scholars have begun to incorporate Kant's moral anthropology. The result has been kantian moral theory that pays…”
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UN PROJET DE RÉFORME DE L'E.N.A by Roussel, Patrick

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Un projet de réforme de l'ENA by ROUSSEL, Patrick

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Anatomie d'un licenciement, l'exemple de Roussel-Uclaf by Roussel, Patrick

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