Search Results - "ROURKE, Claire"

Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy by Davenport, Ross A, Guerreiro, Maria, Frith, Daniel, Rourke, Claire, Platton, Sean, Cohen, Mitchell, Pearse, Rupert, Thiemermann, Chris, Brohi, Karim

“…BACKGROUND:Major trauma is a leading cause of morbidity and mortality worldwide with hemorrhage accounting for 40% of deaths. Acute traumatic coagulopathy…”
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iTACTIC - implementing Treatment Algorithms for the Correction of Trauma-Induced Coagulopathy: study protocol for a multicentre, randomised controlled trial by Baksaas-Aasen, Kjersti, Gall, Lewis, Eaglestone, Simon, Rourke, Claire, Juffermans, Nicole P, Goslings, J Carel, Naess, Paal Aksel, van Dieren, Susan, Ostrowski, Sisse Rye, Stensballe, Jakob, Maegele, Marc, Stanworth, Simon J, Gaarder, Christine, Brohi, Karim, Johansson, Per I

“…Traumatic injury is the fourth leading cause of death globally. Half of all trauma deaths are due to bleeding and most of these will occur within 6 h of…”
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Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis by Curry, Nicola, Davenport, Ross, Thomas, Helen, Fox, Erin, Lucas, Joanne, Evans, Amy, Massou, Efthalia, Sharma, Rupa, Shanmugaranjan, Shaminie, Rourke, Claire, Newton, Alice, Deary, Alison, Dallas, Nikki, Fitzpatrick-Creamer, Chloe, Podbielski, Jeanette M, Wade, Charles E, Edwards, Antoinette, Benger, Jonathan, Morris, Stephen, Cotton, Bryan A, Piercy, James, Green, Laura, Brohi, Karim, Stanworth, Simon

“…Background Traumatic haemorrhage is common after severe injury, leading to disability and death. Cryoprecipitate, a source of fibrinogen, may improve outcomes…”
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Aripiprazole and its human metabolite are partial agonists at the human dopamine D2 receptor, but the rodent metabolite displays antagonist properties by WOOD, Martyn D, SCOTT, Claire, FORBES, Ian T, GRIBBLE, Andrew, CLARKE, Kirsten, WESTAWAY, Julie, DAVIES, Ceri H, REAVILL, Charlie, HILL, Mark, ROURKE, Claire, NEWSON, Michael, JONES, Declan N. C

“…Aripiprazole is a novel antipsychotic drug, which displays partial agonist activity at the dopamine D(2) receptor. Aripiprazole has been extensively studied…”
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Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia by Robbins, Melanie J, Starr, Kathryn R, Honey, Andy, Soffin, Ellen M, Rourke, Claire, Jones, Gareth A, Kelly, Fiona M, Strum, Jay, Melarange, Rosemary A, Harris, Andy J, Rocheville, Magalie, Rupniak, Tom, Murdock, Paul R, Jones, Declan N.C, Kew, James N.C, Maycox, Peter R

“…Abstract Aberrant glutamatergic neurotransmission may underlie the pathogenesis of schizophrenia and metabotropic glutamate receptors (mGluRs) have been…”
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Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial by Baksaas-Aasen, K., Gall, L. S., Stensballe, J., Juffermans, N. P., Curry, N., Maegele, M., Brooks, A., Rourke, C., Gillespie, S., Murphy, J., Maroni, R., Vulliamy, P., Henriksen, H. H., Pedersen, K. Holst, Kolstadbraaten, K. M., Wirtz, M. R., Kleinveld, D. J. B., Schäfer, N., Chinna, S., Davenport, R. A., Naess, P. A., Goslings, J. C., Eaglestone, S., Stanworth, S., Johansson, P. I., Gaarder, C., Brohi, K.

“…Purpose Contemporary trauma resuscitation prioritizes control of bleeding and uses major haemorrhage protocols (MHPs) to prevent and treat coagulopathy. We…”
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Data-driven Development of ROTEM and TEG Algorithms for the Management of Trauma Hemorrhage: A Prospective Observational Multicenter Study by Baksaas-Aasen, Kjersti, Van Dieren, Susan, Balvers, Kirsten, Juffermans, Nicole P, Næss, Pål A, Rourke, Claire, Eaglestone, Simon, Ostrowski, Sisse R, Stensballe, Jakob, Stanworth, Simon, Maegele, Marc, Goslings, J C, Johansson, Pär I, Brohi, Karim, Gaarder, Christine

“…OBJECTIVE:Developing pragmatic data-driven algorithms for management of trauma induced coagulopathy (TIC) during trauma hemorrhage for viscoelastic hemostatic…”
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Safety and efficacy of artesunate treatment in severely injured patients with traumatic hemorrhage. The TOP-ART randomized clinical trial by Shepherd, Joanna M., Ross, Jennifer, Anton, Lourdes, Rourke, Claire, Brentnall, Adam R., Tarning, Joel, White, Nicholas J., Thiemermann, Christoph, Brohi, Karim

“…Purpose This study aimed at determining whether intravenous artesunate is safe and effective in reducing multiple organ dysfunction syndrome in trauma patients…”
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Fibrinogen replacement in trauma haemorrhage by Curry, Nicola, Rourke, Claire, Davenport, Ross, Stanworth, Simon, Brohi, Karim

“…Increased fibrinolysis has been shown to be a major component of acute traumatic coagulopathy [2] and is likely due to both the high levels of free tPA…”
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Diversity in clinical management and protocols for the treatment of major bleeding trauma patients across European level I trauma centres by Schäfer, Nadine, Driessen, Arne, Frölich, Matthias, Stürmer, Ewa K, Maegele, Marc

“…Inneholder sammendrag…”
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Thromboelastometry and organ failure in trauma patients: a prospective cohort study by Müller, Marcella C A, Balvers, Kirsten, Binnekade, Jan M, Curry, Nicola, Stanworth, Simon, Gaarder, Christine, Kolstadbraaten, Knut M, Rourke, Claire, Brohi, Karim, Goslings, J Carel, Juffermans, Nicole P

“…Data on the incidence of a hypercoagulable state in trauma, as measured by thromboelastometry (ROTEM), is limited and the prognostic value of…”
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Rotational thromboelastometry (ROTEM) – The future of haemostatic resuscitation in major trauma centres by Bird, Ruth, Lawless, James, Davenport, Ross, Rourke, Claire, Weaver, Anne, Brohi, Karim, Nevin, Daniel

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Alternative Method of Oral Dosing for Rats by Atcha, Zeenat, Rourke, Claire, Neo, Aveline H.P, Goh, Catherine W.H, Lim, Jean S.K, Aw, Chiu-Cheong, Browne, Edward R, Pemberton, Darrel J

“…Oral administration of drugs to laboratory rodents typically is achieved by using the gavage technique. Although highly effective, this method occasionally can…”
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Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040 by Southam, Eric, Cilia, Jackie, Gartlon, Jane E., Woolley, Marie L., Lacroix, Laurent P., Jennings, Carol A., Cluderay, Jane E., Reavill, Charlie, Rourke, Claire, Wilson, David M., Dawson, Lee A., Medhurst, Andrew D., Jones, Declan N. C.

“…Objectives To test the novel nonimidazole histamine H 3 receptor antagonist 5-[(3-cyclobutyl-2,3,4,5-tetrahydro-1 H -3-benzazapin-7-yl)oxy]- N…”
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Aripiprazole and its human metabolite are partial agonists at the human dopamine D 2 receptor, but the rodent metabolite displays antagonist properties by Wood, Martyn D., Scott, Claire, Clarke, Kirsten, Westaway, Julie, Davies, Ceri H., Reavill, Charlie, Hill, Mark, Rourke, Claire, Newson, Michael, Jones, Declan N.C., Forbes, Ian T., Gribble, Andrew

“…Aripiprazole is a novel antipsychotic drug, which displays partial agonist activity at the dopamine D 2 receptor. Aripiprazole has been extensively studied…”
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Characterisation of olanzapine-induced weight gain and effect of aripiprazole vs olanzapine on body weight and prolactin secretion in female rats by KALINICHEV, Mikhail, ROURKE, Claire, DANIELS, Alex J, GRIZZLE, Mary K, BRITT, Christy S, IGNAR, Diane M, JONES, Declan N. C

“…Atypical antipsychotic drug (APD)-induced weight gain causes non-compliance, increasing the risk of relapse and medical complications. In an animal model, we…”
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Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo by Colom, Bartomeu, Bodkin, Jennifer V., Beyrau, Martina, Woodfin, Abigail, Ody, Christiane, Rourke, Claire, Chavakis, Triantafyllos, Brohi, Karim, Imhof, Beat A., Nourshargh, Sussan

“…Breaching endothelial cells (ECs) is a decisive step in the migration of leukocytes from the vascular lumen to the extravascular tissue, but fundamental…”
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Body weights and plasma prolactin levels in female rats treated subchronically with ziprasidone versus olanzapine by Kalinichev, Mikhail, Rourke, Claire, Jones, Declan N.C

“…In a putative animal model of antipsychotic drug-induced weight gain, female rats received either vehicle, ziprasidone (2.0, 6.0, 10 mg/kg) or olanzapine (2.0…”
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Effects of the atypical antipsychotics olanzapine and risperidone on plasma prolactin levels in male rats : a comparison with clinical data by ROURKE, Claire, STARR, Kathryn R, REAVILL, Charlie, FENWICK, Sue, DEADMAN, Kim, JONES, Declan N. C

“…Hyperprolactinaemia is a common side effect of antipsychotic treatment and the clinical consequences associated with this, e.g. sexual dysfunction, can have a…”
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Hemostatic Effects of Fresh Frozen Plasma May be Maximal at Red Cell Ratios of 1:2 by Davenport, Ross, Curry, Nicola, Manson, Joanna, DeʼAth, Henry, Coates, Amy, Rourke, Claire, Pearse, Rupert, Stanworth, Simon, Brohi, Karim

“…BACKGROUND:Damage control resuscitation targets acute traumatic coagulopathy with the early administration of high-dose fresh frozen plasma (FFP). FFP is…”
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