Search Results - "ROUMELIOTI, Panagiota"

An efficient synthesis of a rationally designed 1,5 disubstituted imidazole AT(1) angiotensin II receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies by Agelis, George, Roumelioti, Panagiota, Resvani, Amalia, Durdagi, Serdar, Androutsou, Maria-Eleni, Kelaidonis, Konstantinos, Vlahakos, Demetrios, Mavromoustakos, Thomas, Matsoukas, John

“…A new 1,5 disubstituted imidazole AT(1) Angiotensin II (AII) receptor antagonist related to losartan with reversion of butyl and hydroxymethyl groups at the…”
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An efficient synthesis of a rationally designed 1,5 disubstituted imidazole AT1 Angiotensin II receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies by Agelis, George, Roumelioti, Panagiota, Resvani, Amalia, Durdagi, Serdar, Androutsou, Maria-Eleni, Kelaidonis, Konstantinos, Vlahakos, Demetrios, Mavromoustakos, Thomas, Matsoukas, John

“…A new 1,5 disubstituted imidazole AT 1 Angiotensin II (AII) receptor antagonist related to losartan with reversion of butyl and hydroxymethyl groups at the 2-,…”
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An Effort To Understand the Molecular Basis of Hypertension through the Study of Conformational Analysis of Losartan and Sarmesin Using a Combination of Nuclear Magnetic Resonance Spectroscopy and Theoretical Calculations by Mavromoustakos, Thomas, Kolocouris, Antonios, Zervou, Maria, Roumelioti, Panagiota, Matsoukas, John, Weisemann, Rudiger

“…Losartan is the first recently approved drug against hypertension disease that competes with the biological action of angiotensin II (AII) at the AT1 receptor…”
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An efficient synthesis of a rationally designed 1,5 disubstituted imidazole AT sub(1) Angiotensin II receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies by Agelis, George, Roumelioti, Panagiota, Resvani, Amalia, Durdagi, Serdar, Androutsou, Maria-Eleni, Kelaidonis, Konstantinos, Vlahakos, Demetrios, Mavromoustakos, Thomas, Matsoukas, John

“…A new 1,5 disubstituted imidazole AT sub(1) Angiotensin II (AII) receptor antagonist related to losartan with reversion of butyl and hydroxymethyl groups at…”
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Design and Synthesis of Novel Biologically Active Thrombin Receptor Non-Peptide Mimetics Based on the Pharmacophoric Cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Leu-Arg46 Motif Sequence:  Platelet Aggregation and Relaxant Activities by Alexopoulos, Kostas, Fatseas, Panagiotis, Melissari, Euthemia, Vlahakos, Demetrios, Roumelioti, Panagiota, Mavromoustakos, Thomas, Mihailescu, Stefan, Paredes-Carbajal, Maria Christina, Mascher, Dieter, Matsoukas, John

“…The identification of the thrombin receptor has promoted the interest for the development of new therapeutic agents capable of selectively inhibiting unwanted…”
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Synthesis and study of a cyclic Angiotensin II antagonist analogue reveals the role of π-π interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT1 non-peptide antagonists by POLEVAYA, Ludmila, MAVROMOUSTAKOS, Thomas, KREMASTINOS, Dimitrios Th, MATSOUKAS, John, ZOUMBOULAKIS, Panagiotis, GRDADOLNIK, Simona Golic, ROUMELIOTI, Panagiota, GIATAS, Nektarios, MUTULE, Ilze, KEIVISH, Tatjana, VLAHAKOS, Demetrios V, ILIODROMITIS, Efstathios K

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Design and Synthesis of Novel Biologically Active Thrombin Receptor Non-Peptide Mimetics Based on the Pharmacophoric Cluster Phe/Arg/NH 2 of the Ser 42 -Phe-Leu-Leu-Arg 46 Motif Sequence:  Platelet Aggregation and Relaxant Activities by Alexopoulos, Kostas, Fatseas, Panagiotis, Melissari, Euthemia, Vlahakos, Demetrios, Roumelioti, Panagiota, Mavromoustakos, Thomas, Mihailescu, Stefan, Paredes-Carbajal, Maria Christina, Mascher, Dieter, Matsoukas, John

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Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-Chain bridges: Role of C-Terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists by Roumelioti, Panagiota, Polevaya, Ludmila, Zoumpoulakis, Panagiotis, Giatas, Nektarios, Mutule, Ilze, Keivish, Tatjana, Zoga, Anastasia, Vlahakos, Demetrios, Iliodromitis, E., Kremastinos, Demetrios, Grdadolnik, Simona Golic, Mavromoustakos, Thomas, Matsoukas, John

“…The novel amide linked Angiotensin II (ANG II) cyclic analogues: γ,ε-cyclo(3, 5)-[Sar 1-Glu 3-Lys 5-Ile 8] ANG II (I) and γ, ε-cyclo(3, 5)-[Sar 1-Glu 3-Lys…”
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Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2of the ser42-phe-leu-leu-arg46 motif sequence: Platelet aggregation and relaxant activities by ALEXOPOULOS, Kostas, FATSEAS, Panagiotis, MELISSARI, Euthemia, VLAHAKOS, Demetrios, ROUMELIOTI, Panagiota, MAVROMOUSTAKOS, Thomas, MIHAILESCU, Stefan, PAREDES-CARBAJAL, Maria Christina, MASCHER, Dieter, MATSOUKAS, John

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The design and synthesis of a potent Angiotensin II cyclic analogue confirms the ring cluster receptor conformation of the hormone Angiotensin II by MATSOUKAS, J. M, POLEVAYA, L, ANCANS, J, MAVROMOUSTAKOS, T, KOLOCOURIS, A, ROUMELIOTI, P, VLAHAKOS, D. V, YAMDAGNI, R, QIAO WU, MOORE, G. J

“…The novel amide linked Angiotensin II potent cyclic analogue, c-[Sar1,Lys3,Glu5] ANG II 19 has been designed and synthesized in an attempt to test the aromatic…”
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Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-Chain bridges by Roumelioti, Panagiota, Polevaya, Ludmila, Zoumpoulakis, Panagiotis, Giatas, Nektarios, Mutule, Ilze, Keivish, Tatjana, Zoga, Anastasia, Vlahakos, Demetrios, Iliodromitis, E., Kremastinos, Demetrios, Grdadolnik, Simona Golic, Mavromoustakos, Thomas, Matsoukas, John

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Structural comparison between type I and type II antagonists : Possible implications in the drug design of AT1 antagonists by ROUMELIOTI, P, TSELIOS, T, ALEXOPOULOS, K, MAVROMOUSTAKOS, T, KOLOCOURIS, A, MOORE, G. J, MATSOUKAS, J. M

“…Analogues of sarilesin (type I AT1 antagonists), and sarmesin (type II AT1 antagonists) with homoserine (hSer) at position 8 were prepared and bioassayed. The…”
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Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of π–π interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT 1 non-peptide antagonists by Polevaya, Ludmila, Mavromoustakos, Thomas, Zoumboulakis, Panagiotis, Grdadolnik, Simona Golic, Roumelioti, Panagiota, Giatas, Nektarios, Mutule, Ilze, Keivish, Tatjana, Vlahakos, Demetrios V, Iliodromitis, Efstathios K, Kremastinos, Dimitrios Th, Matsoukas, John

“…The novel amide linked Angiotensin II (ANG II) cyclic analogue cyclo(3, 5) -[Sar 1-Lys 3-Glu 5-Ile 8] ANG II ( 18) has been designed, synthesized and…”
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