Search Results - "ROUMELIOTI, P"

Conformation and bioactivity. Design and discovery of novel antihypertensive drugs by Mavromoustakos, T, Zervou, M, Zoumpoulakis, P, Kyrikou, I, Benetis, N P, Polevaya, L, Roumelioti, P, Giatas, N, Zoga, A, Minakakis, P Moutevelis, Kolocouris, A, Vlahakos, D, Grdadolnik, S Golic, Matsoukas, J

“…Peptidomimitism is applied to the medicinal chemistry in order to synthesize drugs that devoid of the disadvantages of peptides. AT1 antagonists constitute a…”
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Conformational and biological studies for a pair of novel synthetic AT1 antagonists: stereoelectronic requirements for antihypertensive efficacy by ZOUMPOULAKIS, P, ZOGA, A, ROUMELIOTI, P, GIATAS, N, GRDADOLNIK, S. G, ILIODROMITIS, E, VLAHAKOS, D, KREMASTINOS, D, MATSOUKAS, J. M, MAVROMOUSTAKOS, T

“…One of the major systems which interferes with the disease of hypertension, is the Renin Angiotensin Aldosterone System (RAS). The octapeptide hormone…”
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Design and synthesis of small semi-mimetic peptides with immunomodulatory activity based on myelin basic protein (MBP) by Tselios, T, Probert, L, Kollias, G, Matsoukas, E, Roumelioti, P, Alexopoulos, K, Moore, G J, Matsoukas, J

“…Experimental allergic encephalomyelitis (EAE) is induced in susceptible animals by immunodominant determinants of myelin basic protein (MBP). Analogs of these…”
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A comparative SAR study of thrombin receptor derived non peptide mimetics: importance of phenyl/guanidino proximity for activity by Alexopoulos, K, Matsoukas, J, Tselios, T, Roumelioti, P, Mavromoustakos, T, Holada, K

“…Thrombin, the most potent physiological platelet agonist interacts with cells through a specific G protein-coupled receptor which has been cloned and…”
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An Effort To Understand the Molecular Basis of Hypertension through the Study of Conformational Analysis of Losartan and Sarmesin Using a Combination of Nuclear Magnetic Resonance Spectroscopy and Theoretical Calculations by Mavromoustakos, Thomas, Kolocouris, Antonios, Zervou, Maria, Roumelioti, Panagiota, Matsoukas, John, Weisemann, Rudiger

“…Losartan is the first recently approved drug against hypertension disease that competes with the biological action of angiotensin II (AII) at the AT1 receptor…”
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Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of pi--pi interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT(1) non-peptide antagonists by Polevaya, L, Mavromoustakos, T, Zoumboulakis, P, Golic Grdadolnik, S, Roumelioti, P, Giatas, N, Mutule, I, Keivish, T, Vlahakos, D V, Iliodromitis, E K, Kremastinos, D T, Matsoukas, J

“…The novel amide linked Angiotensin II (ANG II) cyclic analogue cyclo(3, 5) -[Sar(1)-Lys(3)-Glu(5)-Ile(8)] ANG II (18) has been designed, synthesized and…”
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Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-Chain bridges: Role of C-Terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists by Roumelioti, Panagiota, Polevaya, Ludmila, Zoumpoulakis, Panagiotis, Giatas, Nektarios, Mutule, Ilze, Keivish, Tatjana, Zoga, Anastasia, Vlahakos, Demetrios, Iliodromitis, E., Kremastinos, Demetrios, Grdadolnik, Simona Golic, Mavromoustakos, Thomas, Matsoukas, John

“…The novel amide linked Angiotensin II (ANG II) cyclic analogues: γ,ε-cyclo(3, 5)-[Sar 1-Glu 3-Lys 5-Ile 8] ANG II (I) and γ, ε-cyclo(3, 5)-[Sar 1-Glu 3-Lys…”
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The design and synthesis of a potent Angiotensin II cyclic analogue confirms the ring cluster receptor conformation of the hormone Angiotensin II by MATSOUKAS, J. M, POLEVAYA, L, ANCANS, J, MAVROMOUSTAKOS, T, KOLOCOURIS, A, ROUMELIOTI, P, VLAHAKOS, D. V, YAMDAGNI, R, QIAO WU, MOORE, G. J

“…The novel amide linked Angiotensin II potent cyclic analogue, c-[Sar1,Lys3,Glu5] ANG II 19 has been designed and synthesized in an attempt to test the aromatic…”
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Conformational and biological studies for a pair of novel synthetic AT 1 antagonists: stereoelectronic requirements for antihypertensive efficacy by Zoumpoulakis, P., Zoga, A., Roumelioti, P., Giatas, N., Grdadolnik, S.G., Iliodromitis, E., Vlahakos, D., Kremastinos, D., Matsoukas, J.M., Mavromoustakos, T.

“…One of the major systems which interferes with the disease of hypertension, is the Renin Angiotensin Aldosterone System (RAS). The octapeptide hormone…”
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Conformational and biological studies for a pair of novel synthetic AT sub(1) antagonists: stereoelectronic requirements for antihypertensive efficacy by Zoumpoulakis, P, Zoga, A, Roumelioti, P, Giatas, N, Grdadolnik, S G, Iliodromitis, E, Vlahakos, D, Kremastinos, D, Matsoukas, J M, Mavromoustakos, T

“…One of the major systems which interferes with the disease of hypertension, is the Renin Angiotensin Aldosterone System (RAS). The octapeptide hormone…”
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Structural comparison between type I and type II antagonists : Possible implications in the drug design of AT1 antagonists by ROUMELIOTI, P, TSELIOS, T, ALEXOPOULOS, K, MAVROMOUSTAKOS, T, KOLOCOURIS, A, MOORE, G. J, MATSOUKAS, J. M

“…Analogues of sarilesin (type I AT1 antagonists), and sarmesin (type II AT1 antagonists) with homoserine (hSer) at position 8 were prepared and bioassayed. The…”
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