Search Results - "ROULEAU, Mélanie"

Plasma extracellular vesicles as phenotypic biomarkers in prostate cancer patients by Joncas, France‐Hélène, Lucien, Fabrice, Rouleau, Mélanie, Morin, Fannie, Leong, Hon Sing, Pouliot, Frédéric, Fradet, Yves, Gilbert, Caroline, Toren, Paul

“…Background The development of phenotypic biomarkers to aid the selection of treatment for patients with castrate‐resistant prostate cancer (CRPC) is an…”
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Extensive Alteration of Androgen Precursor Levels After Castration in Prostate Cancer Patients and Their Association With Active Androgen Level by Rouleau, Mélanie, Neveu, Bertrand, Caron, Patrick, Morin, Fannie, Toren, Paul, Lacombe, Louis, Turcotte, Véronique, Lévesque, Éric, Guillemette, Chantal, Pouliot, Frédéric

“…PURPOSEDihydrotestosterone and testosterone are thought to be major contributors of prostate cancer progression and resistance. We studied the modulation of 15…”
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Dual roles for splice variants of the glucuronidation pathway as regulators of cellular metabolism by Rouleau, Mélanie, Roberge, Joannie, Bellemare, Judith, Guillemette, Chantal

“…Transcripts of the UGT1A gene, encoding half of human UDP-glucuronosyltransferase (UGT) enzymes, undergo alternative splicing, resulting in active enzymes…”
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Mass spectrometry redefines optimal testosterone thresholds in prostate cancer patients undergoing androgen deprivation therapy by Beck, Jérémie, Rouleau, Mélanie, Lemire, Francis, Neveu, Bertrand, Déry, Michel, Thériault, Benoît, Dubois, Gabriel, Guérette, Dominique, Pouliot, Frédéric

“…Background Androgen deprivation therapy (ADT) is the standard of care for prostate cancer treatment. Studies suggest that patients with testosterone levels…”
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Extragonadal Steroids Contribute Significantly to Androgen Receptor Activity and Development of Castration Resistance in Recurrent Prostate Cancer after Primary Therapy by Pouliot, Frédéric, Rouleau, Mélanie, Neveu, Bertrand, Toren, Paul, Morin, Fannie, Vélot, Lauriane, Ding, Keyue, Caron, Patrick, Lacombe, Louis, Lévesque, Éric, Klotz, Laurence, Guillemette, Chantal

“…Beyond testosterone, several steroids contribute to the activation of the androgen receptor pathway, but their relative contributions to the activation of the…”
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Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models by Kenmogne, Lucie Carolle, Roy, Jenny, Maltais, René, Rouleau, Mélanie, Neveu, Bertrand, Pouliot, Frédéric, Poirier, Donald

“…In the fight against androgen-sensitive prostate cancer, the enzyme 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) is an attractive therapeutic target…”
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Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism by Audet-Delage, Yannick, Rouleau, Michèle, Rouleau, Mélanie, Roberge, Joannie, Miard, Stéphanie, Picard, Frédéric, Têtu, Bernard, Guillemette, Chantal

“…Alternative splicing at the human glucuronosyltransferase 1 gene locus (UGT1) produces alternate isoforms UGT1A_i2s that control glucuronidation activity…”
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Steroidogenic Germline Polymorphism Predictors of Prostate Cancer Progression in the Estradiol Pathway by LEVESQUE, Eric, LAVERDIERE, Isabelle, AUDET-WALSH, Etienne, CARON, Patrick, ROULEAU, Mélanie, FRADET, Yves, LACOMBE, Louis, GUILLEMETTE, Chantal

“…Reliable biomarkers that predict prostate cancer outcomes are urgently needed to improve and personalize treatment approaches. With this goal in mind, we…”
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Molecular Markers in Key Steroidogenic Pathways, Circulating Steroid Levels, and Prostate Cancer Progression by LEVESQUE, Eric, HUANG, Shu-Pin, CARON, Patrick, GUILLEMETTE, Chantal, AUDET-WALSH, Etienne, LACOMBE, Louis, BAO, Bo-Ying, FRADET, Yves, LAVERDIERE, Isabelle, ROULEAU, Mélanie, HUANG, Chao-Yuan, YU, Chia-Cheng

“…Prostate cancer is a heterogeneous genetic disease, and molecular methods for predicting prognosis in patients with aggressive form of the disease are urgently…”
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Modulation of the Human Glucuronosyltransferase UGT1A Pathway by Splice Isoform Polypeptides Is Mediated through Protein-Protein Interactions by Bellemare, Judith, Rouleau, Mélanie, Harvey, Mario, Guillemette, Chantal

“…This study investigated the molecular mechanisms underlying the regulatory effect of the newly discovered 45-kDa enzymatically inactive UGT1A spliced…”
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Importance of 5α-Reductase Gene Polymorphisms on Circulating and Intraprostatic Androgens in Prostate Cancer by LEVESQUE, Eric, LAVERDIERE, Isabelle, LACOMBE, Louis, CARON, Patrick, ROULEAU, Mélanie, TURCOTTE, Véronique, TETU, Bernard, FRADET, Yves, GUILLEMETTE, Chantal

“…Polymorphisms in the genes SRD5A1 and SRD5A2 encoding androgen biosynthetic 5α-reductase enzymes have been associated with an altered risk of biochemical…”
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Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17[beta]-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models by Kenmogne, Lucie Carolle, Roy, Jenny, Maltais, René, Rouleau, Mélanie, Neveu, Bertrand, Pouliot, Frédéric, Poirier, Donald

“…In the fight against androgen-sensitive prostate cancer, the enzyme 17[beta]-hydroxysteroid dehydrogenase type 3 (17[beta]-HSD3) is an attractive therapeutic…”
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Endogenous Protein Interactome of Human UDP-Glucuronosyltransferases Exposed by Untargeted Proteomics by Rouleau, Michèle, Audet-Delage, Yannick, Desjardins, Sylvie, Rouleau, Mélanie, Girard-Bock, Camille, Guillemette, Chantal

“…The conjugative metabolism mediated by UDP-glucuronosyltransferase enzymes (UGTs) significantly influences the bioavailability and biological responses of…”
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Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans by Bellemare, Judith, Rouleau, Mélanie, Harvey, Mario, Popa, Ion, Pelletier, Georges, Têtu, Bernard, Guillemette, Chantal

“…Glucuronidation by UDP‐glucuronyltransferase (UGT) enzymes is the prevailing conjugative pathway for the metabolism of both xenobiotics and endogenous…”
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Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro by BELLEMARE, Judith, ROULEAU, Mélanie, GIRARD, Hugo, HARVEY, Mario, GUILLEMETTE, Chantal

“…UDP-glucuronosyltransferases (UGTs) are major mediators in conjugative metabolism. Current data suggest that UGTs, which are anchored in the endoplasmic…”
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The relative protein abundance of UGT1A alternative splice variants as a key determinant of glucuronidation activity in vitro by Rouleau, Mélanie, Roberge, Joannie, Falardeau, Sarah-Ann, Villeneuve, Lyne, Guillemette, Chantal

“…Alternative splicing (AS) is one of the most significant components of the functional complexity of human UDP-glucuronosyltransferase enzymes (UGTs),…”
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Discordance between testosterone measurement methods in castrated prostate cancer patients by Rouleau, Mélanie, Lemire, Francis, Déry, Michel, Thériault, Benoît, Dubois, Gabriel, Fradet, Yves, Toren, Paul, Guillemette, Chantal, Lacombe, Louis, Klotz, Laurence, Saad, Fred, Guérette, Dominique, Pouliot, Frédéric

“…Failure to suppress testosterone below 0.7 nM in castrated prostate cancer patients is associated with poor clinical outcomes. Testosterone levels in castrated…”
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Extracellular Vesicles in Reprogramming of the Ewing Sarcoma Tumor Microenvironment by Pachva, Manideep C., Lai, Horton, Jia, Andy, Rouleau, Melanie, Sorensen, Poul H.

“…Ewing sarcoma (EwS) is a highly aggressive cancer and the second most common malignant bone tumor of children and young adults. Although patients with…”
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Contribution of extragonadal steroids to the androgen receptor activity and to the castration-resistance development in recurrent prostate cancers after primary therapy by Pouliot, Frederic, Rouleau, Mélanie, Neveu, Bertrand, Toren, Paul, Morin, Fannie, Vélot, Lauriane, Ding, Keyue, Caron, Patrick, Lacombe, Louis, Levesque, Eric, Klotz, Laurence, Guillemette, Chantal

“…Abstract only 148 Background: Beyond testosterone, several steroids contribute to the activation of the androgen receptor (AR) pathway, but their relative…”
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Protein-protein interactions between the bilirubin-conjugating UDP-glucuronosyltransferase UGT1A1 and its shorter isoform 2 regulatory partner derived from alternative splicing by Rouleau, Mélanie, Collin, Pierre, Bellemare, Judith, Harvey, Mario, Guillemette, Chantal

“…The oligomerization of UGTs [UDP (uridine diphosphate)-glucuronosyltransferases] modulates their enzyme activities. Recent findings also indicate that…”
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