Search Results - "ROTHSTEIN, Jay L"

An Abscopal Effect on Lung Metastases in Canine Mammary Cancer Patients Induced by Neoadjuvant Intratumoral Immunotherapy with Cowpea Mosaic Virus Nanoparticles and Anti-Canine PD-1 by Sergent, Petra, Pinto-Cárdenas, Juan Carlos, Carrillo, Adhara Jaciel Arreguin, Dávalos, Daniel Luna, Pérez, Marisa Daniela González, Lechuga, Dora Alicia Mendoza, Alonso-Miguel, Daniel, Schaafsma, Evelien, Cuarenta, Abigail Jiménez, Muñoz, Diana Cárdenas, Zarabanda, Yuliana, Palisoul, Scott M, Lewis, Petra J, Kolling, 4th, Fred W, Affonso de Oliveira, Jessica Fernanda, Steinmetz, Nicole F, Rothstein, Jay L, Lines, Louise, Noelle, Randolph J, Fiering, Steven, Arias-Pulido, Hugo

“…Neoadjuvant intratumoral (IT) therapy could amplify the weak responses to checkpoint blockade therapy observed in breast cancer (BC). In this study, we…”
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Functional expression of the CXCR4 chemokine receptor is induced by RET PTC oncogenes and is a common event in human papillary thyroid carcinomas by CASTELLONE, Maria D, GUARINO, Valentina, FUSCO, Alfredo, SANTORO, Massimo, MELILLO, Rosa Marina, DE FALCO, Valentina, CARLOMAGNO, Francesca, BASOLO, Fulvio, FAVIANA, Pinuccia, KRUHOFFER, Mogens, ORNTOFT, Torben, RUSSELL, John P, ROTHSTEIN, Jay L

“…To identify genes involved in the transformation of thyroid follicular cells, we explored, using DNA oligonucleotide microarrays, the transcriptional response…”
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Pathologic features of Hashimoto's-associated papillary thyroid carcinomas by Di Pasquale, Marcello, Rothstein, Jay L., Palazzo, Juan P.

“…Some investigators have found an increased incidence of papillary carcinoma (PC) of the thyroid in patients with Hashimoto's (autoimmune) thyroiditis (HT),…”
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Cyclooxygenase-2 Expression in Human Thyroid Carcinoma and Hashimoto's Thyroiditis by Cornetta, Anthony J., Russell, John P., Cunnane, Mary, Keane, William M., Rothstein, Jay L.

“…Objectives Cyclooxygenases (COX) are enzymes that catalyze the conversion of arachidonic acid to prostaglandins. COX‐2, unlike the constitutively expressed…”
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RET/Papillary Thyroid Cancer Rearrangement in Nonneoplastic Thyrocytes: Follicular Cells of Hashimoto’s Thyroiditis Share Low-Level Recombination Events with a Subset of Papillary Carcinoma by Rhoden, Kerry J., Unger, Kristian, Salvatore, Giuliana, Yilmaz, Yesim, Vovk, Volodymyr, Chiappetta, Gennaro, Qumsiyeh, Mazin B., Rothstein, Jay L., Fusco, Alfredo, Santoro, Massimo, Zitzelsberger, Horst, Tallini, Giovanni

“…Context: RET/papillary thyroid cancer (PTC) is a marker for papillary thyroid carcinoma, but its specificity has been questioned because of the disputed…”
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Knockout of MCT1 results in total absence of spermatozoa, sex hormones dysregulation, and morphological alterations in the testicular tissue by Bernardino, Raquel L., D’Souza, Warren N., Rato, Luis, Rothstein, Jay L., Dias, Tânia R., Chui, Daniel, Wannberg, Sharon, Alves, Marco G., Oliveira, Pedro F.

“…Lactate is a key metabolite for the normal occurrence of spermatogenesis. In the testis, lactate is produced by the Sertoli cells and transported to germline…”
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Oncoprotein Signaling Mediates Tumor-Specific Inflammation and Enhances Tumor Progression by Pufnock, Jeff S, Rothstein, Jay L

“…The RET/PTC3 (RP3) fusion protein is an oncogene expressed during the development of thyroid cancer and in thyroid epithelial cells of patients with…”
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Identification of Functionally Distinct TRAF Proinflammatory and Phosphatidylinositol 3-Kinase/Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (PI3K/MEK) Transforming Activities Emanating from RET/PTC Fusion Oncoprotein by Wixted, Josephine H.F., Rothstein, Jay L., Eisenlohr, Laurence C.

“…Thyroid carcinomas that harbor RET/PTC oncogenes are well differentiated, relatively benign neoplasms compared with those expressing oncogenic RAS or BRAF…”
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Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor by Degeorge, Katharine C, Degeorge, Jr, Brent R, Testa, James S, Rothstein, Jay L

“…Farnesyltransferase inhibitors (FTI) are small molecule agents originally formulated to inhibit the oncogenic functions of Ras. Although subsequent analysis of…”
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Guanylyl Cyclase C–Induced Immunotherapeutic Responses Opposing Tumor Metastases Without Autoimmunity by Snook, Adam E., Stafford, Benjamin J., Li, Peng, Tan, Gene, Huang, Lan, Birbe, Ruth, Schulz, Stephanie, Schnell, Matthias J., Thakur, Mathew, Rothstein, Jay L., Eisenlohr, Laurence C., Waldman, Scott A.

“…Background One of the greatest impediments to cancer immunotherapy is the paucity of antigens that are tumor specific, sufficiently immunogenic, and shared…”
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Expression of NeuroD and TrkB in developing and aged mouse olfactory epithelium by Nibu, Ken-ichi, Kondo, Kenji, Ohta, Yasushi, Ishibashi, Toshio, Rothstein, Jay L, Kaga, Kimitaka

“…To better understand the roles of NeuroD, a member of the basic helix-loop-helix transcription factor family, during the differentiation of olfactory receptor…”
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bFGF Induces Differentiation and Death of Olfactory Neuroblastoma Cells by Nibu, Ken-icihi, Li, Guoqi, Kaga, Kimitaka, Rothstein, Jay L

“…Olfactory neuroblastoma (ONB) is a highly vascularized and malignant tumor arising in olfactory neuronal precursors from the paranasal sinuses. Previously, we…”
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Oncogenic inflammation and autoimmune disease by Eisenlohr, Laurence C., Rothstein, Jay L.

“…Many models exist to explain the induction and perpetuation of autoimmune diseases. Despite their validation in a variety of animal models, the basis for…”
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Proinflammatory Mediators and Genetic Background in Oncogene Mediated Tumor Progression by Russell, John P, Engiles, Julie B, Rothstein, Jay L

“…RET/PTC3 (RP3) is an oncogenic fusion protein which is frequently expressed in papillary thyroid carcinomas and has been detected in thyroid tissue from…”
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Interleukin 24 is induced by the RET PTC3 oncoprotein and is an autocrine growth factor for epithelial cells by SHINOHARA, Shogo, ROTHSTEIN, Jay L

“…Thyroid cancers, like hematological malignancies, are commonly associated with chromosomal translocations leading to the formation of fusion proteins. Through…”
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The RET/PTC3 oncogene : Metastatic solid-type papillary carcinomas in murine thyroids by POWELL, D. J, RUSSELL, J, ROTHSTEIN, J. L, NIBU, K.-I, GUOQI LI, RHEE, E, LIAO, M, GOLDSTEIN, M, KEANE, W. M, SANTORO, M, FUSCO, A

“…Our research goal is to better understand the mechanisms controlling the initiation and progression of thyroid diseases. One such disease, papillary thyroid…”
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Tyrosine kinase oncoprotein, RET PTC3, induces the secretion of myeloid growth and chemotactic factors by RUSSELL, John P, SHINOHARA, Shogo, MELILLO, Rosa M, CASTELLONE, Maria D, SANTORO, Massimo, ROTHSTEIN, Jay L

“…Differentiated thyroid carcinomas are the most frequent endocrine neoplasms, but account for few cancer-related deaths. Although the indolent growth of these…”
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The TRK-T1 fusion protein induces neoplastic transformation of thyroid epithelium by RUSSELL, John P, POWELL, Daniel J, CUNNANE, Mary, GRECO, Angela, PORTELLA, Giuseppe, SANTORO, Massimo, FUSCO, Alfredo, ROTHSTEIN, Jay L

“…Genetic analysis of human papillary thyroid carcinomas (PTC) has revealed unique chromosomal translocations that form oncogenic fusion proteins and promote…”
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RET/PTC fusion gene rearrangements in Japanese thyroid carcinomas by NIBU, Ken-Ichi, OTSUKI, Naoki, NAKAO, Kazunari, SUGASAWA, Masashi, ROTHSTEIN, Jay L

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Expression of the RET/PTC Fusion Gene as a Marker for Papillary Carcinoma in Hashimoto's Thyroiditis by Wirtschafter, Ari, Schmidt, Richard, Rosen, David, Kundu, Nandita, Santoro, Massimo, Fusco, Alfredo, Multhaupt, Hinke, Atkins, Joseph P., Rosen, Marc R., Keane, William M., Rothstein, Jay L.

“…Hashimoto's thyroiditis is an inflammatory disease of the thyroid gland with autoimmune etiology.1 Patients afflicted with Hashimoto's have a higher risk of…”
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