Search Results - "ROTHSTEIN, J. D"

Glial cells in amyotrophic lateral sclerosis by Philips, T., Rothstein, J.D.

“…For more than twenty years glial cells have been implicated in the pathogenetic cascades for genetic and sporadic forms of ALS. The biological role of glia,…”
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Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection by Tawfik, V.L, Regan, M.R, Haenggeli, C, LaCroix-Fralish, M.L, Nutile-McMenemy, N, Perez, N, Rothstein, J.D, DeLeo, J.A

“…Abstract We have previously shown that the atypical methylxanthine, propentofylline, reduces mechanical allodynia after peripheral nerve transection in a…”
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4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes by Keller, J.N, Mark, R.J, Bruce, A.J, E. Blanc, Rothstein, J.D, Uchida, K, Waeg, G, Mattson, M.P

“…Removal of extracellular glutamate at synapses, by specific high-affinity glutamate transporters, is critical to prevent excitotoxic injury to neurons…”
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The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine by MELONE, M, VITELLARO-ZUCCARELLO, L, VALLEJO-ILLARRAMENDI, A, PEREZ-SAMARTIN, A, MATUTE, C, COZZI, A, PELLEGRINI-GIAMPIETRO, D. E, ROTHSTEIN, J. D, CONTI, F

“…We show here that clozapine, a beneficial antipsychotic, down-regulates the expression of the glutamate transporter GLT-1 in the rat cerebral cortex, thereby…”
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Differential expression of three glutamate transporter subtypes in the rat retina by Rauen, T, Rothstein, J D, Wässle, H

“…The immunocytochemical distribution of the three excitatory amino acid transporter subtypes GLT-1, GLAST-1 and EAAC-1 was studied in the rat retina using…”
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Chronic Inhibition of Glutamate Uptake Produces a Model of Slow Neurotoxicity by Rothstein, Jeffrey D., Jin, Lin, Dykes-Hoberg, Margaret, Kuncl, Ralph W.

“…Defects in neurotransmitter glutamate transport may be an important component of chronic neurotoxicity in diseases such as amyotrophic lateral sclerosis. There…”
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GTRAP3‐18 serves as a negative regulator of Rab1 in protein transport and neuronal differentiation by Maier, S., Reiterer, V., Ruggiero, A. M., Rothstein, J. D., Thomas, S., Dahm, R., Sitte, H. H., Farhan, H.

“…Glutamate transporter associated protein 3–18 (GTRAP3‐18) is an endoplasmic reticulum (ER)‐localized protein belonging to the prenylated rab‐acceptor‐family…”
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Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4 by Furuta, A, Martin, L.J, Lin, C.-L.G, Dykes-Hoberg, M, J. D. Rothstein

“…Glutamate transport is a primary mechanism for the synaptic inactivation of glutamate. Excitatory amino acid transporter 4 (EAAT4) is a novel glutamate…”
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ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions by Bruijn, L.I., Becher, M.W., Lee, M.K., Anderson, K.L., Jenkins, N.A., Copeland, N.G., Sisodia, S.S., Rothstein, J.D., Borchelt, D.R., Price, D.L., Cleveland, D.W.

“…High levels of familial Amyotrophic Lateral Sclerosis (ALS)-linked SOD1 mutants G93A and G37R were previously shown to mediate disease in mice through an…”
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Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis by Rothstein, J D, Van Kammen, M, Levey, A I, Martin, L J, Kuncl, R W

“…The pathogenesis of sporadic amyotrophic lateral sclerosis (ALS) is unknown, but defects in synaptosomal high-affinity glutamate transport have been observed…”
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Decreased glutamate transporter ( GLT-1) expression in frontal cortex of rats with acute liver failure by Knecht, K, Michalak, A, Rose, C, Rothstein, J.D, Butterworth, R.F

“…It has been suggested that reduced astrocytic uptake of neuronally released glutamate contributes to the pathogenesis of hepatic encephalopathy in acute liver…”
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Evidence of neuronal excitatory amino acid carrier 1 expression in rat dorsal root ganglion neurons and their central terminals by Tao, F, Liaw, W.-J, Zhang, B, Yaster, M, Rothstein, J.D, Johns, R.A, Tao, Y.-X

“…The expression and distribution of the neuronal glutamate transporter, excitatory amino acid carrier-1 (EAAC1), are demonstrated in the dorsal root ganglion…”
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Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis by Rothstein, Jeffrey D, Martin, Lee J, Kuncl, Ralph W

“…AMYOTROPHIC lateral sclerosis (ALS) is a chronic progressive disease of unknown pathogenesis that is characterized by the selective degeneration of upper and…”
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Regulation and dysregulation of glutamate transporters by Sattler, R, Rothstein, J D

“…Glutamate is the primary excitatory neurotransmitter in the central nervous system. During synaptic activity, glutamate is released into the synaptic cleft and…”
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Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex by Bristol, L A, Rothstein, J D

“…Glutamate transport is critical for synaptic inactivation of glutamate and prevention of excitotoxicity. The following four glutamate transporters have been…”
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Traumatic Brain Injury Down‐Regulates Glial Glutamate Transporter (GLT‐1 and GLAST) Proteins in Rat Brain by Raghavendra Rao, Vemuganti L., Başkaya, Mustafa K., Doğan, Aclan, Rothstein, Jeffrey D., Dempsey, Robert J.

“…: Excess activation of NMDA receptors is felt to participate in secondary neuronal damage after traumatic brain injury (TBI). Increased extracellular glutamate…”
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Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate by Rothstein, Jeffrey D, Dykes-Hoberg, Margaret, Pardo, Carlos A, Bristol, Lynn A, Jin, Lin, Kuncl, Ralph W, Kanai, Yoshikatsu, Hediger, Matthias A, Wang, Yanfeng, Schielke, Jerry P, Welty, Devin F

“…Three glutamate transporters have been identified in rat, including astroglial transporters GLAST and GLT-1 and a neuronal transporter EAAC1. Here we…”
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Variations in Promoter Activity Reveal a Differential Expression and Physiology of Glutamate Transporters by Glia in the Developing and Mature CNS by Regan, Melissa R, Huang, Yanhua H, Kim, Yu Shin, Dykes-Hoberg, Margaret I, Jin, Lin, Watkins, Andrew M, Bergles, Dwight E, Rothstein, Jeffrey D

“…Glutamate transporters regulate excitatory neurotransmission and prevent glutamate-mediated excitotoxicity in the CNS. To better study the cellular and…”
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Modulation of spinal nociceptive processing through the glutamate transporter GLT-1 by Niederberger, E., Schmidtko, A., Rothstein, J.D., Geisslinger, G., Tegeder, I.

“…GLT-1 is the predominant glutamate transporter in most brain regions and therefore plays a major role in terminating synaptic transmission and protecting…”
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Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity by Rothstein, J D, Kuncl, R W

“…A dramatic loss of glutamate transport has been observed in sporadic amyotrophic lateral sclerosis and has been postulated to contribute to the disease…”
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