Search Results - "ROTHENAIGNER, Ina"

Retinoic acid signaling is critical during the totipotency window in early mammalian development by Iturbide, Ane, Ruiz Tejada Segura, Mayra L., Noll, Camille, Schorpp, Kenji, Rothenaigner, Ina, Ruiz-Morales, Elias R., Lubatti, Gabriele, Agami, Ahmed, Hadian, Kamyar, Scialdone, Antonio, Torres-Padilla, Maria-Elena

“…Totipotent cells hold enormous potential for regenerative medicine. Thus, the development of cellular models recapitulating totipotent-like features is of…”
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ABCA3 Deficiency-Variant-Specific Response to Hydroxychloroquine by Yang, Xiaohua, Forstner, Maria, Rapp, Christina K, Rothenaigner, Ina, Li, Yang, Hadian, Kamyar, Griese, Matthias

“…Biallelic variants in , the gene encoding the lipid transporter ATP-binding cassette subfamily A member 3 (ABCA3) that is predominantly expressed in alveolar…”
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Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis by Tschuck, Juliane, Theilacker, Lea, Rothenaigner, Ina, Weiß, Stefanie A. I., Akdogan, Banu, Lam, Van Thanh, Müller, Constanze, Graf, Roman, Brandner, Stefanie, Pütz, Christian, Rieder, Tamara, Schmitt-Kopplin, Philippe, Vincendeau, Michelle, Zischka, Hans, Schorpp, Kenji, Hadian, Kamyar

“…Ferroptosis is a regulated cell death modality that occurs upon iron-dependent lipid peroxidation. Recent research has identified many regulators that induce…”
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Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development by Tschuck, Juliane, Padmanabhan Nair, Vidya, Galhoz, Ana, Zaratiegui, Carole, Tai, Hin-Man, Ciceri, Gabriele, Rothenaigner, Ina, Tchieu, Jason, Stockwell, Brent R., Studer, Lorenz, Cabianca, Daphne S., Menden, Michael P., Vincendeau, Michelle, Hadian, Kamyar

“…The development of functional neurons is a complex orchestration of multiple signaling pathways controlling cell proliferation and differentiation. Because the…”
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Seratrodast inhibits ferroptosis by suppressing lipid peroxidation by Tschuck, Juliane, Tonnus, Wulf, Gavali, Shubhangi, Kolak, Andrea, Mallais, Melodie, Maremonti, Francesca, Sato, Mami, Rothenaigner, Ina, Friedmann Angeli, José Pedro, Pratt, Derek A., Linkermann, Andreas, Hadian, Kamyar

“…Ferroptosis is a regulated and non-apoptotic form of cell death mediated by iron-dependent peroxidation of polyunsaturated fatty acyl tails in phospholipids…”
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Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development by Iturbide, Ane, Ruiz Tejada Segura, Mayra L., Noll, Camille, Schorpp, Kenji, Rothenaigner, Ina, Ruiz-Morales, Elias R., Lubatti, Gabriele, Agami, Ahmed, Hadian, Kamyar, Scialdone, Antonio, Torres-Padilla, Maria-Elena

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CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting by Schorpp, Kenji, Bessadok, Alaa, Biibosunov, Aidin, Rothenaigner, Ina, Strasser, Stefanie, Peng, Tingying, Hadian, Kamyar

“…Cell death, such as apoptosis and ferroptosis, play essential roles in the process of development, homeostasis, and pathogenesis of acute and chronic diseases…”
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New small molecules targeting apoptosis and cell viability in osteosarcoma by Maugg, Doris, Rothenaigner, Ina, Schorpp, Kenji, Potukuchi, Harish Kumar, Korsching, Eberhard, Baumhoer, Daniel, Hadian, Kamyar, Smida, Jan, Nathrath, Michaela

“…Despite the option of multimodal therapy in the treatment strategies of osteosarcoma (OS), the most common primary malignant bone tumor, the standard therapy…”
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Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism by Hartleben, Goetz, Schorpp, Kenji, Kwon, Yun, Betz, Barbara, Tsokanos, Foivos‐Filippos, Dantes, Zahra, Schäfer, Arlett, Rothenaigner, Ina, Monroy Kuhn, José Manuel, Morigny, Pauline, Mehr, Lisa, Lin, Sean, Seitz, Susanne, Tokarz, Janina, Artati, Anna, Adamsky, Jerzy, Plettenburg, Oliver, Lutter, Dominik, Irmler, Martin, Beckers, Johannes, Reichert, Maximilian, Hadian, Kamyar, Zeigerer, Anja, Herzig, Stephan, Berriel Diaz, Mauricio

“…By accentuating drug efficacy and impeding resistance mechanisms, combinatorial, multi‐agent therapies have emerged as key approaches in the treatment of…”
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Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus by Kramer-Hämmerle, Susanne, Rothenaigner, Ina, Wolff, Horst, Bell, Jeanne E., Brack-Werner, Ruth

“…The availability of highly active antiretroviral therapies (HAART) has not eliminated HIV-1 infection of the central nervous system (CNS) or the occurrence of…”
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Long-term HIV-1 infection of neural progenitor populations by ROTHENAIGNER, Ina, KRAMER, Susanne, ZIEGLER, Manja, WOLFF, Horst, KLEINSCHMIDT, Andrea, BRACK-WERNER, Ruth

“…HIV can reside in the brain for many years. While astrocytes are known to tolerate long-term HIV infection, the potential of other neural cell types to harbour…”
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Image-based high-content screening in drug discovery by Lin, Sean, Schorpp, Kenji, Rothenaigner, Ina, Hadian, Kamyar

“…•Complex phenotypic imaging assays aim at mimicking the biology of interest.•Cellular profiling in high-content assays improve description of compound…”
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Brief Guide: Experimental Strategies for High-Quality Hit Selection from Small-Molecule Screening Campaigns by Rothenaigner, Ina, Hadian, Kamyar

“…Small-molecule screening is a powerful approach to identify modulators of either specific biological targets or cellular pathways with phenotypic endpoints. A…”
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High-Content Screening Identifies Cyclosporin A as a Novel ABCA3-Specific Molecular Corrector by Forstner, Maria, Lin, Sean, Yang, Xiaohua, Kinting, Susanna, Rothenaigner, Ina, Schorpp, Kenji, Li, Yang, Hadian, Kamyar, Griese, Matthias

“…ABCA3 (ATP-binding cassette subfamily A member 3) is a lipid transporter expressed in alveolar type II cells and localized in the limiting membrane of lamellar…”
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Clonal analysis by distinct viral vectors identifies bona fide neural stem cells in the adult zebrafish telencephalon and characterizes their division properties and fate by Rothenaigner, Ina, Krecsmarik, Monika, Hayes, John A, Bahn, Brigitte, Lepier, Alexandra, Fortin, Gilles, Götz, Magdalena, Jagasia, Ravi, Bally-Cuif, Laure

“…Neurogenesis is widespread in the zebrafish adult brain through the maintenance of active germinal niches. To characterize which progenitor properties…”
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Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity by Brenke, Jara K., Popowicz, Grzegorz M., Schorpp, Kenji, Rothenaigner, Ina, Roesner, Manfred, Meininger, Isabel, Kalinski, Cédric, Ringelstetter, Larissa, R'kyek, Omar, Jürjens, Gerrit, Vincendeau, Michelle, Plettenburg, Oliver, Sattler, Michael, Krappmann, Daniel, Hadian, Kamyar

“…Constitutive NF-κB signaling represents a hallmark of chronic inflammation and autoimmune diseases. The E3 ligase TNF receptor–associated factor 6 (TRAF6) acts…”
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Nuisance compounds in cellular assays by Dahlin, Jayme L, Auld, Douglas S, Rothenaigner, Ina, Haney, Steve, Sexton, Jonathan Z, Nissink, J Willem M, Walsh, Jarrod, Lee, Jonathan A, Strelow, John M, Willard, Francis S, Ferrins, Lori, Baell, Jonathan B, Walters, Michael A, Hua, Bruce K, Hadian, Kamyar, Wagner, Bridget K

“…Compounds that exhibit assay interference or undesirable mechanisms of bioactivity ("nuisance compounds") are routinely encountered in cellular assays,…”
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Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3 by Padmanabhan Nair, Vidya, Liu, Hengyuan, Ciceri, Gabriele, Jungverdorben, Johannes, Frishman, Goar, Tchieu, Jason, Cederquist, Gustav Y., Rothenaigner, Ina, Schorpp, Kenji, Klepper, Lena, Walsh, Ryan M., Kim, Tae Wan, Cornacchia, Daniela, Ruepp, Andreas, Mayer, Jens, Hadian, Kamyar, Frishman, Dmitrij, Studer, Lorenz, Vincendeau, Michelle

“…The biological function and disease association of human endogenous retroviruses (HERVs) are largely elusive. HERV-K(HML-2) has been associated with…”
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Cyclosporine A in children with ABCA3 deficiency by Yang, Xiaohua, Forstner, Maria E, Rothenaigner, Ina, Bullo, Marina, Şismanlar, Tugba E, Aslan, Ayse T, Latzin, Philipp, Hadian, Kamyar, Griese, Matthias

“…Biallelic ATP-binding cassette subfamily A member 3 (ABCA3) variants can cause interstitial lung disease in children and adults, for which no proven treatments…”
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Methods to Detect Small Molecule Inhibition of RING E3 Ligase Activity by Rothenaigner, Ina, Brenke, Jara Kerstin, Schorpp, Kenji, Hadian, Kamyar

“…Protein ubiquitination is an essential post-translational modification that regulates a large number of cellular processes. This reaction is facilitated by the…”
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