Search Results - "ROSSI, Tino"

Discovery Process and Pharmacological Characterization of 2-(S)-(4-Fluoro-2-methylphenyl)piperazine-1-carboxylic Acid [1-(R)-(3,5-Bis-trifluoromethylphenyl)ethyl]methylamide (Vestipitant) as a Potent, Selective, and Orally Active NK1 Receptor Antagonist by Di Fabio, Romano, Griffante, Cristiana, Alvaro, Giuseppe, Pentassuglia, Giorgio, Pizzi, Domenica A, Donati, Daniele, Rossi, Tino, Guercio, Giuseppe, Mattioli, Mario, Cimarosti, Zadeo, Marchioro, Carla, Provera, Stefano, Zonzini, Laura, Montanari, Dino, Melotto, Sergio, Gerrard, Philip A, Trist, David G, Ratti, Emiliangelo, Corsi, Mauro

“…In an effort to discover novel druglike NK1 receptor antagonists a new series of suitably substituted C-phenylpiperazine derivatives was identified by an…”
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Quality by Design in lead optimization: a new strategy to address productivity in drug discovery by Rossi, Tino, Braggio, Simone

“…Highlights ► High attrition has put the entire Pharma R&D business model under pressure. ► The selection of quality candidates is key to achieve efficiency and…”
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Stereoselective Synthesis of a Key Intermediate of Sanfetrinem by Means of a Chelated Tin(IV) Enolate by Rossi, Tino, Marchioro, Carla, Paio, Alfredo, Thomas, Russell J, Zarantonello, Paola

“…(2S)-2-Methoxycyclohexanone [(2S)-6], reacts with the 4-acetoxyazetidinone 3a in the presence of SnCl4 and a tertiary amine base (such as…”
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Solution phase library of perhydrooxazin-4-ones by Panunzio, Mauro, Villa, Marzia, Missio, Andrea, Rossi, Tino, Seneci, Pierfausto

“…A general approach to the solution phase parallel synthesis of perhydrooxazin-4-ones, which allows the preparation of milligram quantities of each individual…”
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The synthesis of a key intermediate of tricyclic beta-lactam antibiotics by Bismara, Claudio, Di Fabio, Romano, Donati, Daniele, Rossi, Tino, Thomas, Russell J.

“…By employing an intramolecular Sakurai-type olefination it was possible to obtain the olefin 5, a key intermediate in the synthesis of the broad spectrum…”
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1,2,4-Triazol-3-yl-thiopropyl-tetrahydrobenzazepines:  A Series of Potent and Selective Dopamine D 3 Receptor Antagonists by Micheli, Fabrizio, Bonanomi, Giorgio, Blaney, Frank E., Braggio, Simone, Capelli, Anna Maria, Checchia, Anna, Curcuruto, Ornella, Damiani, Federica, Di Fabio, Romano, Donati, Daniele, Gentile, Gabriella, Gribble, Andy, Hamprecht, Dieter, Tedesco, Giovanna, Terreni, Silvia, Tarsi, Luca, Lightfoot, Andrew, Stemp, Geoff, MacDonald, Gregor, Smith, Alex, Pecoraro, Michela, Petrone, Marcella, Perini, Ornella, Piner, Jacqui, Rossi, Tino, Worby, Angela, Pilla, Maria, Valerio, Enzo, Griffante, Cristiana, Mugnaini, Manolo, Wood, Martyn, Scott, Claire, Andreoli, Michela, Lacroix, Laurent, Schwarz, Adam, Gozzi, Alessandro, Bifone, Angelo, Ashby, Charles R., Hagan, Jim J., Heidbreder, Christian

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Analogues of 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole as potential antibacterial agents by ANTOLINI, M, BOZZOLI, A, GHIRON, C, KENNEDY, G, ROSSI, T, URSINI, A

“…A preliminary exploration of analogues of 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole, 1, as novel antibacterial agents was carried out to…”
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Dopamine D 3 receptor antagonists: The quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies by Bennacef, Idriss, Salinas, Cristian A., Bonasera, Thomas A., Gunn, Roger N., Audrain, Hélène, Jakobsen, Steen, Nabulsi, Nabeel, Weinzimmer, David, Carson, Richard E., Huang, Yiyun, Holmes, Ian, Micheli, Fabrizio, Heidbreder, Christian, Gentile, Gabriella, Rossi, Tino, Laruelle, Marc

“…Radiosynthesis and in vivo testing for a potential Dopamine D 3 PET ligand are reported. Compound 1 is a potent and selective antagonist of the dopamine D 3…”
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Application of LC-NMR to the identification of bulk drug impurities in NK1 antagonist GW597599 (vestipitant) by Provera, Stefano, Guercio, Giuseppe, Turco, Lucilla, Curcuruto, Ornella, Alvaro, Giuseppe, Rossi, Tino, Marchioro, Carla

“…Liquid chromatography‐NMR (LC–NMR) spectroscopy was used to obtain detailed information regarding the structure of the major bulk drug impurities present in…”
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Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies by BENNACEF, Idriss, SALINAS, Cristian A, HOLMES, Ian, MICHELI, Fabrizio, HEIDBREDER, Christian, GENTILE, Gabriella, ROSSI, Tino, LARUELLE, Marc, BONASERA, Thomas A, GUNN, Roger N, AUDRAIN, Hélène, JAKOBSEN, Steen, NABULSI, Nabeel, WEINZIMMER, David, CARSON, Richard E, YIYUN HUANG

“…Compound 1 is a potent and selective antagonist of the dopamine D(3) receptor. With the aim of developing a carbon-11 labeled ligand for the dopamine D(3)…”
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1,2,4-Triazol-3-yl-thiopropyl-tetrahydrobenzazepines:  A Series of Potent and Selective Dopamine D3 Receptor Antagonists by Micheli, Fabrizio, Bonanomi, Giorgio, Blaney, Frank E, Braggio, Simone, Capelli, Anna Maria, Checchia, Anna, Curcuruto, Ornella, Damiani, Federica, Di Fabio, Romano, Donati, Daniele, Gentile, Gabriella, Gribble, Andy, Hamprecht, Dieter, Tedesco, Giovanna, Terreni, Silvia, Tarsi, Luca, Lightfoot, Andrew, Stemp, Geoff, MacDonald, Gregor, Smith, Alex, Pecoraro, Michela, Petrone, Marcella, Perini, Ornella, Piner, Jacqui, Rossi, Tino, Worby, Angela, Pilla, Maria, Valerio, Enzo, Griffante, Cristiana, Mugnaini, Manolo, Wood, Martyn, Scott, Claire, Andreoli, Michela, Lacroix, Laurent, Schwarz, Adam, Gozzi, Alessandro, Bifone, Angelo, Ashby, Charles R, Hagan, Jim J, Heidbreder, Christian

“…The discovery of new highly potent and selective dopamine D3 receptor antagonists has recently permitted characterization of the role of the dopamine D3…”
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Dopamine D sub(3) receptor antagonists: The quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies by Bennacef, Idriss, Salinas, Cristian A, Bonasera, Thomas A, Gunn, Roger N, Audrain, Helene, Jakobsen, Steen, Nabulsi, Nabeel, Weinzimmer, David, Carson, Richard E, Huang, Yiyun, Holmes, Ian, Micheli, Fabrizio, Heidbreder, Christian, Gentile, Gabriella, Rossi, Tino, Laruelle, Marc

“…Compound 1 is a potent and selective antagonist of the dopamine D sub(3) receptor. With the aim of developing a carbon-11 labeled ligand for the dopamine D…”
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Discovery Process and Pharmacological Characterization of 2-( S )-(4-Fluoro-2-methylphenyl)piperazine-1-carboxylic Acid [1-( R )-(3,5-Bis-trifluoromethylphenyl)ethyl]methylamide (Vestipitant) as a Potent, Selective, and Orally Active NK 1 Receptor Antagonist by Di Fabio, Romano, Griffante, Cristiana, Alvaro, Giuseppe, Pentassuglia, Giorgio, Pizzi, Domenica A., Donati, Daniele, Rossi, Tino, Guercio, Giuseppe, Mattioli, Mario, Cimarosti, Zadeo, Marchioro, Carla, Provera, Stefano, Zonzini, Laura, Montanari, Dino, Melotto, Sergio, Gerrard, Philip A., Trist, David G., Ratti, Emiliangelo, Corsi, Mauro

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1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines: a series of potent and selective dopamine D(3) receptor antagonists by Micheli, Fabrizio, Bonanomi, Giorgio, Blaney, Frank E, Braggio, Simone, Capelli, Anna Maria, Checchia, Anna, Curcuruto, Ornella, Damiani, Federica, Fabio, Romano Di, Donati, Daniele, Gentile, Gabriella, Gribble, Andy, Hamprecht, Dieter, Tedesco, Giovanna, Terreni, Silvia, Tarsi, Luca, Lightfoot, Andrew, Stemp, Geoff, Macdonald, Gregor, Smith, Alex, Pecoraro, Michela, Petrone, Marcella, Perini, Ornella, Piner, Jacqui, Rossi, Tino, Worby, Angela, Pilla, Maria, Valerio, Enzo, Griffante, Cristiana, Mugnaini, Manolo, Wood, Martyn, Scott, Claire, Andreoli, Michela, Lacroix, Laurent, Schwarz, Adam, Gozzi, Alessandro, Bifone, Angelo, Ashby, Jr, Charles R, Hagan, Jim J, Heidbreder, Christian

“…The discovery of new highly potent and selective dopamine D3 receptor antagonists has recently permitted characterization of the role of the dopamine D3…”
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Nitrate ester derivatives from epoxides using CAN: Efficient preparation of key intermediates in the synthesis of 4-alkoxytrinems by Di Fabio, Romano, Rossi, Tino, Thomas, Russell J.

“…A regio and stereoselective opening reaction of epoxide with CAN (0.5 equivalents) in aprotic solvents is descried. This novel reaction allowed the preparation…”
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Solid-phase/solution-phase combinatorial synthesis of neuroimmunophilin ligands by Rabinowitz, M, Seneci, P, Rossi, T, Dal Cin, M, Deal, M, Terstappen, G

“…A novel solid-phase/solution-phase strategy for the synthesis of neuroimmunophilin ligands based on GPI 1046 was developed. The synthesis employs a solid-phase…”
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The stereoselective synthesis of 4-formyltrinem, a key intermediate for novel trinems by Ghiron, Chiara, Rossi, Tino, Thomas, Russell J.

“…The stereoselective synthesis of a protected 4-formyltrinem 8 was accomplished in good yield. This compound is a potential intermediate in the synthesis of a…”
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Novel Amidoalkylation of 4-Acetoxyazetidinones with Allylic Boranes. A Stereoselective Entry into the Tribactams by Rossi, Tino, Biondi, Stefano, Contini, Stefania, Thomas, Russell J, Marchioro, Carla

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Highly Diastereoselective Synthesis of 4- N-Methylformamidino Trinem (GV129606), a Potent Antibacterial Agent by Biondi, Stefano, Pecunioso, Angelo, Busi, Filippo, Contini, Stefania A, Donati, Daniele, Maffeis, Micaela, Pizzi, Domenica A, Rossi, Luciana, Rossi, Tino, Sabbatini, Fabio M

“…In this paper a highly diastereoselective synthesis of 4- N-methylformamidino trinem 3 is reported. The route offers advantages compared to that previously…”
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Synthesis of polymer-bound fischer chromium alkoxy and aminocarbene complexes by Maiorana, Stefano, Seneci, Pierfausto, Rossi, Tino, Baldoli, Clara, Ciraco', Manuela, de Magistris, Elisabetta, Licandro, Emanuela, Papagni, Antonio, Provera, Stefano

“…A series of polymer-bound Fischer chromium alkoxy and amino carbene type I complexes were synthesized by the thermal exchange of a CO ligand in chromium…”
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