Search Results - "ROSSI, G. A"

Key mechanisms governing resolution of lung inflammation by Robb, C. T., Regan, K. H., Dorward, D. A., Rossi, A. G.

“…Innate immunity normally provides excellent defence against invading microorganisms. Acute inflammation is a form of innate immune defence and represents one…”
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Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications by Boyapati, R K, Rossi, A G, Satsangi, J, Ho, G-T

“…Endogenous damage-associated molecular patterns (DAMPs) are released during tissue damage and have increasingly recognized roles in the etiology of many human…”
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Cyclin‐dependent kinase inhibitor drugs as potential novel anti‐inflammatory and pro‐resolution agents by Leitch, AE, Haslett, C, Rossi, AG

“…The cyclin‐dependent kinase inhibitor (CDKi) drugs such as R‐roscovitine have emerged as potential anti‐inflammatory, pharmacological agents that can influence…”
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Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung by Lucas, C D, Dorward, D A, Tait, M A, Fox, S, Marwick, J A, Allen, K C, Robb, C T, Hirani, N, Haslett, C, Duffin, R, Rossi, A G

“…Phagocytes not only coordinate acute inflammation and host defense at mucosal sites, but also contribute to tissue damage. Respiratory infection causes a…”
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Regular vs prn nebulized treatment in wheeze preschool children by Papi, A, Nicolini, G, Baraldi, E, Boner, A.L, Cutrera, R, Rossi, G.A, Fabbri, L.M

“…International guidelines recommend regular treatment with inhaled glucocorticoids for children with frequent wheezing; however, prn inhaled bronchodilator…”
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High serum levels of tumour necrosis factor-α and interleukin-8 in severe asthma: markers of systemic inflammation? by Silvestri, M., Bontempelli, M., Giacomelli, M., Malerba, M., Rossi, G. A., Di Stefano, A., Rossi, A., Ricciardolo, F. L. M.

“…Summary Background Severe asthma is characterized by elevated levels of pro‐inflammatory cytokines and neutrophilic inflammation in the airways. Blood…”
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Optical projection tomography permits efficient assessment of infarct volume in the murine heart postmyocardial infarction by Zhao, X, Wu, J, Gray, C D, McGregor, K, Rossi, A G, Morrison, H, Jansen, M A, Gray, G A

“…The extent of infarct injury is a key determinant of structural and functional remodeling following myocardial infarction (MI). Infarct volume in experimental…”
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Interferon-gamma and IL-10 may protect from allergic polysensitization in children: preliminary evidence by Prigione, I, Morandi, F, Tosca, M.A, Silvestri, M, Pistoia, V, Ciprandi, G, Rossi, G.A

“…To cite this article: Prigione I, Morandi F, Tosca MA, Silvestri M, Pistoia V, Ciprandi G, Rossi GA. Interferon-gamma and IL-10 may protect from allergic…”
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5α‐Reduced glucocorticoids exhibit dissociated anti‐inflammatory and metabolic effects by Yang, C, Nixon, M, Kenyon, CJ, Livingstone, DEW, Duffin, R, Rossi, AG, Walker, BR, Andrew, R

“…BACKGROUND AND PURPOSE Dissociating anti‐inflammatory efficacy from the metabolic side effects of glucocorticoids is an attractive therapeutic goal…”
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Nitric oxide: a key regulator of myeloid inflammatory cell apoptosis by Taylor, E L, Megson, I L, Haslett, C, Rossi, A G

“…Apoptosis of inflammatory cells is a critical event in the resolution of inflammation, as failure to undergo this form of cell death leads to increased tissue…”
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Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation by Heasman, SJ, Giles, KM, Ward, C, Rossi, AG, Haslett, C, Dransfield, I

“…Glucocorticoids represent one of the most effective clinical treatments for a range of inflammatory conditions, including severe acute inflammation. Although…”
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"Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa" by Leitch, A E, Duffin, R, Haslett, C, Rossi, A G

“…The respiratory mucosa is responsible for gas exchange and is therefore, of necessity, exposed to airborne pathogens, allergens, and foreign particles. It has…”
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DNA bacterial load in children with bacteremic pneumococcal community-acquired pneumonia by Esposito, S., Marchese, A., Tozzi, A. E., Rossi, G. A., Da Dalt, L., Bona, G., Pelucchi, C., Schito, G. C., Principi, N.

“…This study was conducted to evaluate the association between pneumococcal DNA load and parapneumonic pleural effusion (PPE) in children with community-acquired…”
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IgE in childhood asthma: relevance of demographic characteristics and polysensitisation by Silvestri, M, Pistorio, A, Battistini, E, Rossi, G A

“…Background Despite the therapeutic efficacy of the anti-IgE monoclonal antibody, the role of IgE in allergic asthma is still a matter of debate. This may be…”
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Cysteinyl leukotrienes induce human eosinophil locomotion and adhesion molecule expression via a CysLT1 receptor-mediated mechanism by Fregonese, L., Silvestri, M., Sabatini, F., Rossi, G. A.

“…Summary Background The mechanisms involved in eosinophil recruitment by cysteinyl‐leukotrienes (CysLTs) remain to be defined. Objective We investigated whether…”
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Prevalence of respiratory syncytial virus infection in Italian infants hospitalized for acute lower respiratory tract infections, and association between respiratory syncytial virus infection risk factors and disease severity by Lanari, M., Giovannini, M., Giuffré, L., Marini, A., Rondini, G., Rossi, G. A., Merolla, R., Zuccotti, G.V., Salvioli, G.P.

“…This study was designed to collect data on the prevalence of respiratory syncytial virus (RSV) infection in Italy in infants hospitalized for lower respiratory…”
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Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma by CRIMI, E, SPANEVELLO, A, NERI, M, IND, P. W, ROSSI, G. A, BRUSASCO, V

“…In asthma, the acute increment of airway responsiveness caused by exposure to allergen is associated with influx of eosinophils into the airways. The…”
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Mechanisms of bradykinin-induced contraction in human fetal lung fibroblasts by Petecchia, L, Sabatini, F, Usai, C, Carnevali, S, Ognibene, M, Vanni, C, Eva, A, Fabbri, L M, Rossi, G A, Ricciardolo, F L M

“…Bradykinin (BK) induces fibroblast contraction but the structural changes and intracellular mechanisms involved have not been completely explored. We…”
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Glucocorticoid Augmentation of Macrophage Capacity for Phagocytosis of Apoptotic Cells Is Associated with Reduced p130Cas Expression, Loss of Paxillin/pyk2 Phosphorylation, and High Levels of Active Rac by Giles, Katherine M, Ross, Katherine, Rossi, Adriano G, Hotchin, Neil A, Haslett, Christopher, Dransfield, Ian

“…Phagocytic clearance of apoptotic granulocytes has a pivotal role in determining an inflammatory outcome, resolution or progression to a chronic state…”
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Differential role of CD80 and CD86 on alveolar macrophages in the presentation of allergen to T lymphocytes in asthma by Balbo, P., Silvestri, M., Rossi, G. A., Crimi, E., Burastero, S. E.

“…In the asthmatic lung the altered expression of costimulatory molecules (CD80, CD86) by alveolar macrophages contributes to T lymphocyte activation and…”
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