Search Results - "ROSSANT, Janet"

Genetic Control of Early Cell Lineages in the Mammalian Embryo by Rossant, Janet

“…Establishing the different lineages of the early mammalian embryo takes place over several days and several rounds of cell divisions from the fertilized egg…”
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Mouse and human blastocyst-derived stem cells: vive les differences by Rossant, Janet

“…Lessons learned from conserved vertebrate developmental pathways have catalyzed rapid advances in pluripotent stem cell differentiation towards therapeutically…”
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The role of FGF/Erk signaling in pluripotent cells by Lanner, Fredrik, Rossant, Janet

“…Fibroblast growth factor (FGF) signaling controls fundamental processes such as proliferation, differentiation and migration throughout mammalian development…”
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Early human embryonic development: Blastocyst formation to gastrulation by Rossant, Janet, Tam, Patrick P L

“…There has been recent renewed interest in studying human early embryonic development. The advent of improved culture conditions to maintain blastocysts…”
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FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst by Yamanaka, Yojiro, Lanner, Fredrik, Rossant, Janet

“…Primitive endoderm (PE) and epiblast (EPI) are two lineages derived from the inner cell mass (ICM) of the E3.5 blastocyst. Recent studies showed that EPI and…”
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The Hippo Pathway Member Nf2 Is Required for Inner Cell Mass Specification by Cockburn, Katie, Biechele, Steffen, Garner, Jodi, Rossant, Janet

“…During mammalian development, the first two lineages to be specified are the trophectoderm (TE) and the inner cell mass (ICM). The Hippo pathway kinases Lats 1…”
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Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo by Ralston, Amy, Rossant, Janet

“…The first lineage decision during mouse development is the establishment of trophectoderm and inner cell mass lineages, morphologically distinguishable at the…”
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Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse by Rossant, Janet, Tam, Patrick P L

“…The investigation into lineage allocation and early asymmetries in the pre- and peri-implantation mouse embryo is gaining momentum. As we review here, new…”
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Early Lineage Segregation between Epiblast and Primitive Endoderm in Mouse Blastocysts through the Grb2-MAPK Pathway by Chazaud, Claire, Yamanaka, Yojiro, Pawson, Tony, Rossant, Janet

“…It has been thought that early inner cell mass (ICM) is a homogeneous population and that cell position in the ICM leads to the formation of two lineages,…”
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The Impact of Developmental Biology on Pluripotent Stem Cell Research: Successes and Challenges by Rossant, Janet

“…Research on developmental pathways in model organisms provides key information on how to isolate, maintain, and differentiate human pluripotent stem cells…”
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Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin by Stephenson, Robert Odell, Yamanaka, Yojiro, Rossant, Janet

“…The first two cell lineages in the mouse, the surface trophectoderm (TE) and inner cell mass (ICM), are morphologically distinguishable by E3.5, with the outer…”
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Stem cells and lineage development in the mammalian blastocyst by Rossant, Janet

“…The mammalian blastocyst is the source of the most pluripotent stem cells known: embryonic stem (ES) cells. However, ES cells are not totipotent; in mouse…”
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Endothelial cells and VEGF in vascular development by Rossant, Janet, Coultas, Leigh, Chawengsaksophak, Kallayanee

“…The intricate patterning processes that establish the complex vascular system during development depend on a combination of intrinsic pre-patterning and…”
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Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts by Kabiri, Zahra, Greicius, Gediminas, Madan, Babita, Biechele, Steffen, Zhong, Zhendong, Zaribafzadeh, Hamed, Edison, Aliyev, Jamal, Wu, Yonghui, Bunte, Ralph, Williams, Bart O, Rossant, Janet, Virshup, David M

“…Wnt/β-catenin signaling supports intestinal homeostasis by regulating proliferation in the crypt. Multiple Wnts are expressed in Paneth cells as well as other…”
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Evaluating totipotency using criteria of increasing stringency by Posfai, Eszter, Schell, John Paul, Janiszewski, Adrian, Rovic, Isidora, Murray, Alexander, Bradshaw, Brian, Yamakawa, Tatsuya, Pardon, Tine, El Bakkali, Mouna, Talon, Irene, De Geest, Natalie, Kumar, Pankaj, To, San Kit, Petropoulos, Sophie, Jurisicova, Andrea, Pasque, Vincent, Lanner, Fredrik, Rossant, Janet

“…Totipotency is the ability of a single cell to give rise to all of the differentiated cell types that build the conceptus, yet how to capture this property in…”
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Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor by Wei, George Zhang, Martin, Katherine A., Xing, Peter Yuli, Agrawal, Ruchi, Whiley, Luke, Wood, Thomas K., Hejndorf, Sophia, Ng, Yong Zhi, Low, Jeremy Zhi Yan, Rossant, Janet, Nechanitzky, Robert, Holmes, Elaine, Nicholson, Jeremy K., Tan, Eng-King, Matthews, Paul M., Pettersson, Sven

“…While modulatory effects of gut microbes on neurological phenotypes have been reported, the mechanisms remain largely unknown. Here, we demonstrate that…”
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Influence of FGF4 and BMP4 on FGFR2 dynamics during the segregation of epiblast and primitive endoderm cells in the pre-implantation mouse embryo by Goissis, Marcelo D, Bradshaw, Brian, Posfai, Eszter, Rossant, Janet

“…Specification of the epiblast (EPI) and primitive endoderm (PE) in the mouse embryo involves fibroblast growth factor (FGF) signaling through the RAS/MAP…”
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Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos by Biechele, Steffen, Cox, Brian J., Rossant, Janet

“…Wnt signaling plays important roles in development and disease. The X-chromosomal Porcupine homolog gene (Porcn) encodes an evolutionary conserved member of…”
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Debate ethics of embryo models from stem cells by Rivron, Nicolas, Pera, Martin, Rossant, Janet, Martinez Arias, Alfonso, Zernicka-Goetz, Magdalena, Fu, Jianping, van den Brink, Susanne, Bredenoord, Annelien, Dondorp, Wybo, de Wert, Guido, Hyun, Insoo, Munsie, Megan, Isasi, Rosario

“…International discussion must guide research, urge Nicolas Rivron, Martin Pera and colleagues. International discussion must guide research, urge Nicolas…”
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Notch and Hippo Converge on Cdx2 to Specify the Trophectoderm Lineage in the Mouse Blastocyst by Rayon, Teresa, Menchero, Sergio, Nieto, Andres, Xenopoulos, Panagiotis, Crespo, Miguel, Cockburn, Katie, Cañon, Susana, Sasaki, Hiroshi, Hadjantonakis, Anna-Katerina, de la Pompa, Jose Luis, Rossant, Janet, Manzanares, Miguel

“…The first lineage choice in mammalian embryogenesis is that between the trophectoderm, which gives rise to the trophoblast of the placenta, and the inner cell…”
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