Search Results - "ROSOL, Thomas J"

The role of Dickkopf-1 in bone development, homeostasis, and disease by Pinzone, Joseph J., Hall, Brett M., Thudi, Nanda K., Vonau, Martin, Qiang, Ya-Wei, Rosol, Thomas J., Shaughnessy, John D.

“…Wnt/β-catenin signaling is central to bone development and homeostasis in adulthood and its deregulation is associated with bone pathologies. Dickkopf-1…”
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On-target Effects of GLP-1 Receptor Agonists on Thyroid C-cells in Rats and Mice by Rosol, Thomas J.

“…Glucagon-like peptide-1 is an incretin hormone from the gastrointestinal tract, which enhances insulin secretion, slows gastric emptying, and reduces food…”
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Recommendations from the INHAND Apoptosis/Necrosis Working Group by Elmore, Susan A., Dixon, Darlene, Hailey, James R., Harada, Takanori, Herbert, Ronald A., Maronpot, Robert R., Nolte, Thomas, Rehg, Jerold E., Rittinghausen, Susanne, Rosol, Thomas J., Satoh, Hiroshi, Vidal, Justin D., Willard-Mack, Cynthia L., Creasy, Dianne M.

“…Historically, there has been confusion relating to the diagnostic nomenclature for individual cell death. Toxicologic pathologists have generally used the…”
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Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer by TRIMBOLI, Anthony J, FUKINO, Koichi, OSTROWSKI, Michael C, LEONE, Gustavo, DE BRUIN, Alain, GUO WEI, LEI SHEN, TANNER, Stephan M, CREASAP, Nicholas, ROSOL, Thomas J, ROBINSON, Michael L, ENG, Charis

“…We developed stromal- and epithelial-specific cre-transgenic mice to directly visualize epithelial-mesenchymal transition (EMT) during cancer progression in…”
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Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System by Brändli-Baiocco, Annamaria, Balme, Emmanuelle, Bruder, Marc, Chandra, Sundeep, Hellmann, Juergen, Hoenerhoff, Mark J., Kambara, Takahito, Landes, Christian, Lenz, Barbara, Mense, Mark, Rittinghausen, Susanne, Satoh, Hiroshi, Schorsch, Frédéric, Seeliger, Frank, Tanaka, Takuji, Tsuchitani, Minoru, Wojcinski, Zbigniew, Rosol, Thomas J.

“…The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint…”
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The Effect of a Histone Deacetylase Inhibitor (AR‐42) on Canine Prostate Cancer Growth and Metastasis by Elshafae, Said M., Kohart, Nicole A., Altstadt, Lucas A., Dirksen, Wessel P., Rosol, Thomas. J.

“…BACKGROUND Canine prostate cancer (PCa) is an excellent preclinical model for human PCa. AR‐42 is a histone deacetylase inhibitor (HDACi) developed at The Ohio…”
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Editorial: Triple-negative breast cancer: Heterogeneity, tumor microenvironment and targeted therapy by Deng, Xiyun, Zheng, Chanjuan, Tang, Faqing, Rosol, Thomas J, Shao, Zhi-Ming

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Loss of myoferlin redirects breast cancer cell motility towards collective migration by Volakis, Leonithas I, Li, Ruth, Ackerman, 4th, William E, Mihai, Cosmin, Bechel, Meagan, Summerfield, Taryn L, Ahn, Christopher S, Powell, Heather M, Zielinski, Rachel, Rosol, Thomas J, Ghadiali, Samir N, Kniss, Douglas A

“…Cell migration plays a central role in the invasion and metastasis of tumors. As cells leave the primary tumor, they undergo an epithelial to mesenchymal…”
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Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner by Studebaker, Adam W, Storci, Gianluca, Werbeck, Jillian L, Sansone, Pasquale, Sasser, A Kate, Tavolari, Simona, Huang, Tim, Chan, Michael W Y, Marini, Frank C, Rosol, Thomas J, Bonafé, Massimiliano, Hall, Brett M

“…Common sites of breast cancer metastasis include the lung, liver, and bone, and of these secondary metastatic sites, estrogen receptor alpha (ERalpha)-positive…”
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An Ets2-Driven Transcriptional Program in Tumor-Associated Macrophages Promotes Tumor Metastasis by ZABUAWALA, Tahera, TAFFANY, David A, OSTROWSKI, Michael C, SHARMA, Sudarshana M, MERCHANT, Anand, ADAIR, Brett, SRINIVASAN, Ruchika, ROSOL, Thomas J, FERNANDEZ, Soledad, KUN HUANG, LEONE, Gustavo

“…Tumor-associated macrophages (TAM) are implicated in breast cancer metastasis, but relatively little is known about the underlying genes and pathways that are…”
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Gastrin-releasing peptide receptor (GRPr) promotes EMT, growth, and invasion in canine prostate cancer by Elshafae, Said M., Hassan, Bardes B., Supsavhad, Wachiraphan, Dirksen, Wessel P., Camiener, Rachael Y., Ding, Haiming, Tweedle, Michael F., Rosol, Thomas J.

“…BACKGROUND The gastrin‐releasing peptide receptor (GRPr) is upregulated in early and late‐stage human prostate cancer (PCa) and other solid tumors of the…”
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Stromal PTEN determines mammary epithelial response to radiotherapy by Sizemore, Gina M., Balakrishnan, Subhasree, Thies, Katie A., Hammer, Anisha M., Sizemore, Steven T., Trimboli, Anthony J., Cuitiño, Maria C., Steck, Sarah A., Tozbikian, Gary, Kladney, Raleigh D., Shinde, Neelam, Das, Manjusri, Park, Dongju, Majumder, Sarmila, Krishnan, Shiva, Yu, Lianbo, Fernandez, Soledad A., Chakravarti, Arnab, Shields, Peter G., White, Julia R., Yee, Lisa D., Rosol, Thomas J., Ludwig, Thomas, Park, Morag, Leone, Gustavo, Ostrowski, Michael C.

“…The importance of the tumor–associated stroma in cancer progression is clear. However, it remains uncertain whether early events in the stroma are capable of…”
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Investigating PSMA differential expression in canine uroepithelial carcinomas to aid disease-based stratification and guide therapeutic selection by Berry, Matthew R, Fadl-Alla, Bahaa A, Samuelson, Jonathan, Rosol, Thomas J, Fan, Timothy M

“…In male dogs, uroepithelial cancers include invasive urothelial carcinoma (iUC) and prostate carcinoma (PCA). The inability to distinguish iUC involving the…”
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Histotripsy focal ablation of implanted prostate tumor in an ACE-1 canine cancer model by Schade, George R, Keller, Jill, Ives, Kim, Cheng, Xu, Rosol, Thomas J, Keller, Evan, Roberts, William W

“…Histotripsy is a nonthermal ablative focused ultrasound technology with possible future applications for prostate cancer focal therapy. We used the ACE-1…”
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Dickkopf-1 (DKK-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases by Thudi, Nanda K., Martin, Chelsea K., Murahari, Sridhar, Shu, Sherry T., Lanigan, Lisa G., Werbeck, Jillian L., Keller, Evan T., McCauley, Laurie K., Pinzone, Joseph J., Rosol, Thomas J.

“…BACKGROUND Osteoblastic bone metastasis is the predominant phenotype observed in prostate cancer patients and is associated with high patient mortality and…”
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Effects of Dickkopf-1 (DKK-1) on Prostate Cancer Growth and Bone Metastasis by Yuan, Shiyu, Hoggard, Nathan K, Kantake, Noriko, Hildreth, 3rd, Blake E, Rosol, Thomas J

“…Osteoblastic bone metastases are commonly detected in patients with advanced prostate cancer (PCa) and are associated with an increased mortality rate…”
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Discovery and characterization of the feline miRNAome by Laganà, Alessandro, Dirksen, Wessel P., Supsavhad, Wachiraphan, Yilmaz, Ayse Selen, Ozer, Hatice G., Feller, James D., Vala, Kiersten A., Croce, Carlo M., Rosol, Thomas J.

“…The domestic cat is an important human companion animal that can also serve as a relevant model for ~250 genetic diseases, many metabolic and degenerative…”
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Tumor expressed PTHrP facilitates prostate cancer‐induced osteoblastic lesions by Liao, Jinhui, Li, Xin, Koh, Amy J., Berry, Janice E., Thudi, Nanda, Rosol, Thomas J., Pienta, Kenneth J., McCauley, Laurie K.

“…Expression of parathyroid hormone‐related protein (PTHrP) correlates with prostate cancer skeletal progression; however, the impact of prostate cancer‐derived…”
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Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia by Pitarresi, Jason R, Liu, Xin, Sharma, Sudarshana M, Cuitiño, Maria C, Kladney, Raleigh D, Mace, Thomas A, Donohue, Sydney, Nayak, Sunayana G, Qu, Chunjing, Lee, James, Woelke, Sarah A, Trela, Stefan, LaPak, Kyle, Yu, Lianbo, McElroy, Joseph, Rosol, Thomas J, Shakya, Reena, Ludwig, Thomas, Lesinski, Gregory B, Fernandez, Soledad A, Konieczny, Stephen F, Leone, Gustavo, Wu, Jinghai, Ostrowski, Michael C

“…Abstract Preclinical studies have suggested that the pancreatic tumor microenvironment both inhibits and promotes tumor development and growth. Here we…”
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A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone by HALVORSON, Kyle G, KUBOTA, Kazufumi, SEVCIK, Molly A, LINDSAY, Theodore H, SOTILLO, Julio E, GHILARDI, Joseph R, ROSOL, Thomas J, BOUSTANY, Leila, SHELTON, David L, MANTYH, Patrick W

“…Prostate cancer is unique in that bone is often the only clinically detectable site of metastasis. Prostate tumors that have metastasized to bone frequently…”
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