Search Results - "ROSOFF, P. M"

Genitourinary complications of sickle cell disease by Bruno, D, Wigfall, D R, Zimmerman, S A, Rosoff, P M, Wiener, J S

“…In the last half century the molecular biology, pathophysiology and natural history of sickle cell disease have been well defined. Sickle cell disease causes…”
Get more information

Pharmacology of pertussis toxin B-oligomer by Wong, W S, Rosoff, P M

“…Pertussis toxin (PTX) is a heterohexameric protein, which is divided into subunits A and B. The A-subunit (protomer) possesses adenine diphosphate (ADP)…”
Get more information

Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation by TREDE, N. S, WARWICK, A. B, ROSOFF, P. M, ROHRER, R, BIERER, B. E, GUINAN, E

“…Severe aplastic anemia (SAA) is a frequent complication of orthotopic liver transplantation for non-typeable viral hepatitis. Allogeneic bone marrow…”
Get full text

Mechanisms of pertussis toxin‐induced myelomonocytic cell adhesion: role of Mac‐1(CD11b/CD18) and urokinase receptor (CD87) by WONG, W. S. F., SIMON, D. I., ROSOFF, P. M., RAO, N. K., CHAPMAN, H. A.

“…Stimulation of monoblastic U937 cells with transforming growth factor β1 and 1,25‐(OH)2 vitamin D3 (TGF‐β1/D3) upregulates urokinase receptor (uPAR) and…”
Get full text

Granulocyte-Macrophage Colony-stimulating Factor Primes Neutrophils by Activating a Pertussis Toxin-sensitive G Protein Not Associated with Phosphatidylinositol Turnover by Corey, S J, Rosoff, P M

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic cytokine which produces diverse biological effects in target cells of myeloid…”
Get full text

Sebaceous gland carcinoma : a subtle second malignancy following radiation therapy in patients with bilateral retinoblastoma by HOWREY, R. P, LIPHAM, W. J, SCHULTZ, W. H, BUCKLEY, E. G, DUTTON, J. J, KLINTWORTH, G. K, ROSOFF, P. M

“…Second primary malignancies are common after bilateral retinoblastoma; their estimated incidence has been as high as 51% 50 years after diagnosis. Fifteen…”
Get full text

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx by Oettgen, H C, Terhorst, C, Cantley, L C, Rosoff, P M

“…Three monoclonal antibodies selected for their recognition of parts of the T3-T cell receptor complex on human T lymphocytes were found to induce an increase…”
Get more information

Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange by Rosoff, P M, Stein, L F, Cantley, L C

“…The murine pre-B-lymphocyte cell line 70Z /3 may be induced to differentiate to a surface immunoglobulin-positive phenotype by the polyclonal B-cell mitogen,…”
Get full text

The role of the L3T4 molecule in mitogen and antigen-activated signal transduction by Rosoff, P M, Burakoff, S J, Greenstein, J L

“…We investigated the role of the L3T4 molecule in mitogen and antigen-initiated signal transduction in the L3T4(+) murine T cell hybridoma, 3DT52.5.9 and an…”
Get more information

Myelodysplasia and deficiency of uridine diphosphate–galactose 4-epimerase by Rosoff, Philip M.

“…A 4-year-old girl known to have peripheral uridine diphosphate–galactose 4-epimerase deficiency was examined for bruising and thrombocytopenia. She had…”
Get full text

Pertussis toxin triggers rapid second messenger production in human T lymphocytes by Rosoff, PM, Walker, R, Winberry, L

“…Pertussis toxin (PT) is a known mitogen for T lymphocytes. The mechanism by which the toxin stimulates proliferation has remained obscure and paradoxical…”
Get full text

Congenital bone marrow failure with myelodysplasia in siblings by Rosoff, P M

“…I describe two siblings who have a novel congenital bone marrow failure syndrome with myelodysplastic features without progression to malignancy for 13 and 20…”
Get more information

Increasing the Intracellular Na+Concentration Induces Differentiation in a Pre-B Lymphocyte Cell Line by Rosoff, Philip M., Cantley, Lewis C.

“…The ability of lipopolysaccharide (LPS), a polyclonal B-cell mitogen, to induce differentiation in the pre-B cell tumor line 70Z/3 can be mimicked by drugs…”
Get full text

FOLLICLE-DERIVED THYROID CANCER IN YOUNG PEOPLE: The Duke Experience by McGregor, Lisa M., Rosoff, Philip M.

“…Follicle-derived thyroid cancer is rare in the young. The authors examined a population with a low rate of radiation exposure and who were treated at a single…”
Get full text

Homozygous sickle cell disease and cystic fibrosis in an adolescent by Warwick, Anne B., Haver, Kenan, Rosoff, Philip M.

Get full text

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism by Rosoff, P M, Savage, N, Dinarello, C A

“…We have investigated the biochemical mechanism by which interleukin-1 (IL-1) serves as a comitogen with agents that directly activate the antigen receptor in T…”
Get more information

PAPILLARY ADENOCARCINOMA OF THE THYROID IN A THYROGLOSSAL DUCT CYST by Rosoff, Philip M., McGregor, Lisa M.

“…A case report is presented of an 8-year-old boy who underwent resection of a thyroglossal duct cyst to illustrate a rare, but significant, complication of a…”
Get full text

Ewing's tumor and papillary adenocarcinoma of the thyroid in a 14-year-old girl by CASTELLINO, S, TRAWEEK, T, ROSOFF, P. M

“…We describe an adolescent girl with Stage 1 Ewing's tumor and localized papillary adenocarcinoma of the thyroid gland, a previously unreported association. A…”
Get full text

Reconstitution of a T cell receptor-stimulated plasma membrane calcium transporter: lack of dependence on inositol phosphates by O'Riordan, C, Rosoff, P M

“…The activation of T lymphocytes, like many cells, requires a rapid rise in intracellular Ca2+ secondary to both an influx and a release from intracellular…”
Get more information

Modulation of the intracellular Ca2+ and inositol trisphosphate concentrations in murine T lymphocytes by the glycosylphosphatidylinositol-anchored protein sgp-60 by Maschek, BJ, Zhang, W, Rosoff, PM, Reiser, H

“…Stimulation of T lymphocytes via the TCR/CD3 complex initiates a series of intracellular biochemical events. Among the earliest cellular responses are the…”
Get full text