Search Results - "ROSING, H"

Development and validation of an integrated LC-MS/MS assay for therapeutic drug monitoring of five PARP-inhibitors by Bruin, M.A.C., de Vries, N., Lucas, L., Rosing, H., Huitema, A.D.R., Beijnen, J.H.

“…•A validated LC-MS/MS assay for the combined analysis of five PARP-inhibitors.•Optimization of general MS parameters to gain sufficient sensitivity for…”
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A real or apparent decrease in glomerular filtration rate in patients using olaparib? by Bruin, M. A. C., Korse, C. M., van Wijnen, B., de Jong, V. M. T., Linn, S. C., van Triest, B., Rosing, H., Beijnen, J. H., van den Broek, D., Huitema, A. D. R.

“…Purpose Olaparib is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated for ovarian and metastatic breast cancer. Increased serum creatinine levels have…”
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Validation and clinical application of an LC-MS/MS method for the quantification of everolimus using volumetric absorptive microsampling by Verheijen, R.B., Thijssen, B., Atrafi, F., Schellens, J.H.M., Rosing, H., de Vries, N., Beijnen, J.H., Mathijssen, R.H.J., Steeghs, N., Huitema, A.D.R.

“…Everolimus is a mammalian target of rapamycin inhibitor approved for the treatment of various tumor types. Less invasive measurement of everolimus…”
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Development and validation of a liquid chromatography–tandem mass spectrometry analytical method for the therapeutic drug monitoring of eight novel anticancer drugs by Herbrink, M., Vries, N., Rosing, H., Huitema, A. D. R., Nuijen, B., Schellens, J. H. M., Beijnen, J. H.

“…To support therapeutic drug monitoring of patients with cancer, a fast and accurate method for simultaneous quantification of the registered anticancer drugs…”
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Therapeutic drug monitoring-based precision dosing of oral targeted therapies in oncology: a prospective multicenter study by Groenland, S.L., van Eerden, R.A.G., Westerdijk, K., Meertens, M., Koolen, S.L.W., Moes, D.J.A.R., de Vries, N., Rosing, H., Otten, H., Vulink, A.J.E., Desar, I.M.E., Imholz, A.L.T., Gelderblom, H., van Erp, N.P., Beijnen, J.H., Mathijssen, R.H.J., Huitema, A.D.R., Steeghs, N.

“…Oral targeted therapies show a high pharmacokinetic (PK) interpatient variability. Even though exposure has been positively correlated with efficacy for many…”
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Volumetric absorptive microsampling (VAMS) as an alternative to conventional dried blood spots in the quantification of miltefosine in dried blood samples by Kip, A.E., Kiers, K.C., Rosing, H., Schellens, J.H.M., Beijnen, J.H., Dorlo, T.P.C.

“…•Volumetric absorptive microsampling (VAMS) method validated for miltefosine quantification in human blood.•This novel matrix sampling method eliminates…”
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A systematic meta-analysis and meta-synthesis of the impact of service-learning programs on university students’ empathy by Gordon, Chloe S., Pink, M.A., Rosing, H., Mizzi, S.

“…Higher education institutions seek not only to prepare students for their chosen profession, but also to develop graduates that are civic minded and make a…”
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Development and validation of an UPLC-MS/MS method for the therapeutic drug monitoring of oral anti-hormonal drugs in oncology by van Nuland, M., Venekamp, N., de Vries, N., de Jong, K.A.M., Rosing, H., Beijnen, J.H.

“…A liquid chromatography-mass spectrometry assay was developed and validated for simultaneous quantification of anti-hormonal compounds abiraterone,…”
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A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS/MS by van der Heijden, L.T., Gebretensae, A., Thijssen, B., van Andel, L., Nijstad, A.L., Wang, Y., Rosing, H., Huitema, A.D.R., Beijnen, J.H.

“…A highly sensitive method was developed for the quantification of vinblastine, vincristine, vinorelbine, and its active metabolite 4-O-deacetylvinorelbine in…”
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Development and Validation of an LC-MS/MS Method for the Simultaneous Quantification of Abiraterone, Enzalutamide, and Their Major Metabolites in Human Plasma by van Nuland, Merel, Hillebrand, M J X, Rosing, H, Schellens, J H M, Beijnen, J H

“…Abiraterone acetate and enzalutamide are 2 novel drugs for the treatment of metastatic castration-resistant prostate cancer. The metabolism of these drugs is…”
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Tandem mass spectrometry of small-molecule signal transduction inhibitors: Accurate-m/z data to adapt structure proposals of product ions by Niessen, W.M.A., Hillebrand, M.J.X., Rosing, H., Beijnen, J.H.

“…[Display omitted] •Protein kinases inhibitors are important in the treatment of various cancers.•Therapeutic drug monitoring using liquid chromatography–tandem…”
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Stability of oxaliplatin in chloride-containing carrier solutions used in hyperthermic intraperitoneal chemotherapy by Mehta, A.M., Van den Hoven, J.M., Rosing, H., Hillebrand, M.J.X., Nuijen, B., Huitema, A.D.R., Beijnen, J.H., Verwaal, V.J.

“…[Display omitted] Oxaliplatin is increasingly becoming the chemotherapeutic drug of choice for the treatment of peritoneal malignancies using cytoreductive…”
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Exposure–response analyses of BRAF- and MEK-inhibitors dabrafenib plus trametinib in melanoma patients by Groenland, Stefanie L., Janssen, J. M., Nijenhuis, C. M., de Vries, N., Rosing, H., Wilgenhof, S., van Thienen, J. V., Haanen, J. B. A. G., Blank, C. U., Beijnen, J. H., Huitema, A. D. R., Steeghs, N.

“…Introduction Dabrafenib and trametinib are currently administered at fixed doses, at which interpatient variability in exposure is high. The aim of this study…”
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Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine by van Andel, L., Zhang, Z., Lu, S., Kansra, V., Agarwal, S., Hughes, L., Tibben, M.M., Gebretensae, A., Rosing, H., Schellens, J.H.M., Beijnen, J.H.

“…•The first reported validated LC–MS/MS assay for niraparib and its metabolite M1.•The assay has successfully been validated in the 1–500 and 1–100ng/mL…”
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Exposure–response analyses of abiraterone and its metabolites in real-world patients with metastatic castration-resistant prostate cancer by van Nuland, M., Groenland, S. L., Bergman, A. M., Steeghs, N., Rosing, H., Venekamp, N., Huitema, A. D. R., Beijnen, J. H.

“…Background Abiraterone acetate is an oral 17α-hydroxylase/C17,20-lyase (CYP17) inhibitor approved for the treatment of metastatic castration-resistant prostate…”
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Metabolic Disposition of Lurbinectedin, a Potent Selective Inhibitor of Active Transcription of Protein-Coding Genes, in Nonclinical Species and Patients by Aviles, P, Altares, R, van Andel, L, Lubomirov, R, Fudio, S, Rosing, H, Márquez Del Pino, F M, Tibben, M M, Benedit, G, Nan-Offeringa, L, Luepke Estefan, X E, Francesch, A, Zeaiter, A, Cuevas, C, Schellens, J H M, Beijnen, J H

“…Lurbinectedin is a novel and potent selective inhibitor of active transcription of protein-coding genes, triggering apoptosis of cancerous cells. It has been…”
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Development and validation of a UPLC-MS/MS method with a broad linear dynamic range for the quantification of morphine, morphine-3-glucuronide and morphine-6-glucuronide in mouse plasma and tissue homogenates by Heydari, P., Martins, M.L.F., Rosing, H., Hillebrand, M.J.X., Gebretensae, A., Schinkel, A.H., Beijnen, J.H.

“…•Validated LC-MS/MS method for quantification of morphine and its major metabolites.•Concurrent analysis of morphine, morphine-3-glucuronide, and…”
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Liquid chromatography-tandem mass spectrometric assay for the quantification of galunisertib in human plasma and the application in a pre-clinical study by Tibben, M.M., Huijberts, S., Li, W., Schinkel, A.H., Gebretensae, A., Rosing, H., Beijnen, J.H.

“…•First reported quantitative assay for the determination of galunisertib in human plasma.•Fast and elegant HPLC-MS/MS method for quantification of galunisertib…”
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Method development and validation for the quantification of dasatinib, erlotinib, gefitinib, imatinib, lapatinib, nilotinib, sorafenib and sunitinib in human plasma by liquid chromatography coupled with tandem mass spectrometry by Lankheet, N. A. G., Hillebrand, M. J. X., Rosing, H., Schellens, J. H. M., Beijnen, J. H., Huitema, A. D. R.

“…ABSTRACT To support pharmacokinetic‐guided dosing in individual patients, a fast and accurate method for simultaneous determination of anticancer tyrosine…”
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Increased Oral Bioavailability of Topotecan in Combination With the Breast Cancer Resistance Protein and P-Glycoprotein Inhibitor GF120918 by KRUIJTZER, C. M. F, BEIJNEN, J. H, ROSING, H, TEN BOKKEL HUININK, W. W, SCHOT, M, JEWELL, R. C, PAUL, E. M, SCHELLENS, J. H. M

“…We discovered that breast cancer resistance protein (BCRP), a recently identified adenosine triphosphate-binding cassette drug transporter, substantially…”
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