Search Results - "ROSENTHAL, G. J"

Delivery of Flt3 ligand (Flt3L) using a poloxamer-based formulation increases biological activity in mice by ROBINSON, S. N, CHAVEZ, J. M, PISAREV, V. M, MOSLEY, R. L, ROSENTHAL, G. J, BLONDER, J. M, TALMADGE, J. E

“…Fms-like tyrosine kinase (Flt3L) is a potent stimulator of hematopoietic progenitor cell (HPC) expansion and mobilization; however, this requires 7-10 days of…”
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Human recombinant hemoglobin (rHb1.1) inhibits nonadrenergic noncholinergic (NANC) nerve-mediated relaxation of internal anal sphincter by Rattan, S, Rosenthal, G J, Chakder, S

“…Nitric oxide (NO) plays a significant role in the nonadrenergic noncholinergic nerve-mediated relaxation of gastrointestinal smooth muscle. Furthermore,…”
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Selective effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and corticosteroid on in vitro lymphocyte maturation by Luster, M.I, Germolec, D.R, Clark, G, Wiegand, G, Rosenthal, G.J

“…The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the corticosteroid dexamethasone have potent effects on lymphocyte function,…”
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In vivo and in vitro influence of human recombinant hemoglobin on esophageal function by Chakder, S, Rosenthal, G J, Rattan, S

“…The purpose of the present investigation was to examine the influence of a nitric oxide scavenger, hemoglobin (Hb), on esophageal function. Intraluminal…”
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Qualitative and quantitative experimental models to aid in risk assessment for immunotoxicology by Luster, M I, Pait, D G, Portier, C, Rosenthal, G J, Germolec, D R, Comment, C E, Munson, A E, White, K, Pollock, P

“…We have previously reported on the design and content of a screening battery using a "tier" approach for detecting potential immunosuppressive compounds in…”
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Inappropriate use of venous duplex scans: An analysis of indications and results by Fowl, Richard J., Strothman, Gregory B., Blebea, John, Rosenthal, Gary J., Kempczinski, Richard F.

“…Purpose: The increasing demand for venous duplex scans despite the relative rarity of detecting acute deep venous thrombosis (DVT) prompted us to review our…”
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Thymocyte injury after in vitro chemical exposure: potential mechanisms for thymic atrophy by Comment, C E, Blaylock, B L, Germolec, D R, Pollock, P L, Kouchi, Y, Brown, H W, Rosenthal, G J, Luster, M I

“…In addition to hepatic injury, thymic atrophy is a common observation in rodent subchronic toxicity studies. We have examined representative chemicals which…”
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Pluronic ® F127-based systemic vaccine delivery systems by Coeshott, Claire M., Smithson, S.Louise, Verderber, Evie, Samaniego, Adrian, Blonder, Joan M., Rosenthal, Gary J., Westerink, M.A.Julie

“…We have developed a vaccine delivery system based on the non-ionic block copolymer, Pluronic ® F127 (F127), combined with selected immunomodulators. F127-based…”
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A protective role for T lymphocytes in asbestos-induced pulmonary inflammation and collagen deposition by Corsini, E, Luster, M I, Mahler, J, Craig, W A, Blazka, M E, Rosenthal, G J

“…Several lines of evidence have suggested that specific (i.e., lymphocyte) immunity plays a role in chemical-induced pulmonary diseases, including asbestosis…”
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Suppression of B cell function by methotrexate and trimetrexate. Evidence for inhibition of purine biosynthesis as a major mechanism of action by Rosenthal, GJ, Weigand, GW, Germolec, DR, Blank, JA, Luster, MI

“…Methotrexate (MTX) is a widely used drug in the treatment of a variety of human neoplasms. Trimetrexate (TMQ) is a lipid-soluble quinazoline derivate of MTX…”
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Management of myasthenia gravis by extended thymectomy with anterior mediastinal dissection by Nussbaum, M S, Rosenthal, G J, Samaha, F J, Grinvalsky, H T, Quinlan, J G, Schmerler, M, Fischer, J E

“…Thymectomy has continued to gain acceptance as definitive treatment for myasthenia gravis. Because of the nature of thymic embryology with scattered rests…”
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Particle characteristics and lung deposition patterns in a human airway replica of a dry powder formulation of polylactic acid produced using supercritical fluid technology by Cheng, Y S, Yazzie, D, Gao, J, Muggli, D, Etter, J, Rosenthal, G J

“…Polylactic acid (PLA) powders have been used as vector particles to carry pharmaceutical material. Drugs incorporated in the PLA powder can be retained in the…”
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Pentamidine isethionate reduces Ia expression and antigen presentation by Langerhans cells and inhibits the contact hypersensitivity reaction by Blaylock, BL, Kouchi, Y, Comment, CE, Corsini, E, Rosenthal, GJ, Luster, MI

“…The mechanism of action of pentamidine isethionate, a diamidino compound used in the treatment of Pneumocystis carinii pneumonia, is unknown. We recently…”
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Effect of recombinant human hemoglobin on human bone marrow progenitor cells: protection and reversal of 3′ -azido-3′ -deoxythymidine-induced toxicity by Fowler, David A., Rosenthal, Gary J., Sommadossi, Jean-Pierre

“…Long-term therapy of AIDS patients with 3′ -azido-3′ -deoxythymidine (AZT) is limited by hematopoietic toxicity. While the mechanism(s) of this toxicity remain…”
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Perturbations of the Immune System by Xenobiotics by Luster, Michael I., Ackermann, Michael F., Germolec, Dori R., Rosenthal, Gary J.

“…Classically, immunotoxicology has been defined as the study of adverse effects on the immune system associated with exposure to environmental chemicals,…”
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Chemical Agents and the Immune Response by Luster, Michael I., Rosenthal, Gary J.

“…Our desire to understand the potential adverse human health effects of environmental chemical exposure has coincided with an increased understanding of the…”
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Dose-dependent hyperlipidemia in rabbits following administration of poloxamer 407 gel by Blonder, Joan M., Baird, Linda, Fulfs, Jon C., Rosenthal, Gary J.

“…Poloxamer 407 (P-407) is a tri-block polymer that exhibits concentrationdependent reverse thermal gelation, a characteristic potentially useful for developing…”
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Pentamidine blocks the pathophysiologic effects of endotoxemia through inhibition of cytokine release by Rosenthal, G J, Craig, W A, Corsini, E, Taylor, M, Luster, M I

“…Pentamidine isethionate, an antiprotozoal agent with therapeutic value against Pneumocystis carinii pneumonia, has been used for over 30 years without a…”
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Environmentally related disorders of the hematologic and immune systems by Luster, M I, Wierda, D, Rosenthal, G J

“…From observations in rodents and, to a lesser extent, in humans inadvertently or occupationally exposed, it appears that a number of xenobiotics adversely…”
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Modulation of the immune response to Listeria monocytogenes by benzene inhalation by Rosenthal, G J, Snyder, C A

“…Benzene is a potent bone marrow toxicant. While all blood cell types are targets for benzene poisoning, lymphocytes are particularly sensitive. The immunotoxic…”
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