Search Results - "ROSENTHAL, Dean S"

Employing CRISPR-Cas9 to Generate CD133 Synthetic Lethal Melanoma Stem Cells by Simbulan-Rosenthal, Cynthia M, Haribabu, Yogameenakshi, Vakili, Sahar, Kuo, Li-Wei, Clark, Havens, Dougherty, Ryan, Alobaidi, Ryyan, Carney, Bonnie, Sykora, Peter, Rosenthal, Dean S

“…Malignant melanoma is a lethal skin cancer containing melanoma-initiating cells (MIC) implicated in tumorigenesis, invasion, and drug resistance, and is…”
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Hypopigmented burn hypertrophic scar contains melanocytes that can be signaled to re-pigment by synthetic alpha-melanocyte stimulating hormone in vitro by Carney, Bonnie C, Travis, Taryn E, Moffatt, Lauren T, Johnson, Laura S, McLawhorn, Melissa M, Simbulan-Rosenthal, Cynthia M, Rosenthal, Dean S, Shupp, Jeffrey W

“…There are limited treatments for dyschromia in burn hypertrophic scars (HTSs). Initial work in Duroc pig models showed that regions of scar that are light or…”
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A Review of the Local Pathophysiologic Bases of Burn Wound Progression by SHUPP, Jeffrey W, NASABZADEH, Teresa J, ROSENTHAL, Dean S, JORDAN, Marion H, FIDLER, Philip, JENG, James C

“…Burn wound progression refers to the phenomenon of continued tissue necrosis in the zone of stasis after abatement of the initial thermal insult. A multitude…”
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A Nude Mouse Model of Xenografted Hypertrophic Scar Cells to Test Therapeutics in the Skin by Carney, Bonnie C, Simbulan-Rosenthal, Cynthia M, Rosenthal, Dean S, Shupp, Jeffrey W

“…Existing animal models for testing therapeutics in the skin are limited. Mouse and rat models lack similarity to human skin in structure and wound healing…”
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Skin Immuno-CometChip in 3D vs. 2D Cultures to Screen Topical Toxins and Skin-Specific Cytochrome Inducers by Rosenthal, Dean S, Kuo, Li-Wei, Seagrave, Sarah L, Soni, Vikas, Islam, Nusrat, Minsky, Geetanjali, Dussan-Cuellar, Lucia, Ell, Brian, Simbulan-Rosenthal, Cynthia M, Sykora, Peter

“…The targets of topical genotoxic agents are basal and stem cells of the skin. These cells may misrepair DNA lesions, resulting in deleterious mutations of…”
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CD133 Stimulates Cell Proliferation via the Upregulation of Amphiregulin in Melanoma by Simbulan-Rosenthal, Cynthia M, Islam, Nusrat, Haribabu, Yogameenakshi, Alobaidi, Ryyan, Shalamzari, Azadeh, Graham, Garrett, Kuo, Li-Wei, Sykora, Peter, Rosenthal, Dean S

“…CD133, a cancer stem cell (CSC) marker in tumors, including melanoma, is associated with tumor recurrence, chemoresistance, and metastasis. Patient-derived…”
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Inorganic polyphosphate in platelet rich plasma accelerates re-epithelialization in vitro and in vivo by Carney, Bonnie C., Simbulan-Rosenthal, Cynthia M., Gaur, Anirudh, Browne, Benjamin J., Moghe, Manish, Crooke, Elliott, Moffatt, Lauren T., Shupp, Jeffrey W., Rosenthal, Dean S.

“…Wound healing requires well-coordinated events including hemostasis, inflammation, proliferation, and remodeling. Delays in any of these stages leads to…”
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Inorganic polyphosphates are important for cell survival and motility of human skin keratinocytes by Simbulan-Rosenthal, Cynthia M., Gaur, Anirudh, Sanabria, Virginia A., Dussan, Lucia J., Saxena, Rahul, Schmidt, Jozef, Kitani, Takashi, Chen, You-shin, Rahim, Said, Uren, Aykut, Crooke, Elliott, Rosenthal, Dean S.

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Proteomic analysis of pathways involved in estrogen-induced growth and apoptosis of breast cancer cells by Hu, Zhang-Zhi, Kagan, Benjamin L, Ariazi, Eric A, Rosenthal, Dean S, Zhang, Lihua, Li, Jordan V, Huang, Hongzhan, Wu, Cathy, Jordan, V Craig, Riegel, Anna T, Wellstein, Anton

“…Estrogen is a known growth promoter for estrogen receptor (ER)-positive breast cancer cells. Paradoxically, in breast cancer cells that have been chronically…”
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Treatment Strategies for Hypopigmentation in the Context of Burn Hypertrophic Scars by Carney, Bonnie C., McKesey, Jacqueline P., Rosenthal, Dean S., Shupp, Jeffrey W.

“…Dyspigmentation in burn scars can contribute to the development of psychosocial complications after injury and can be detrimental to social reintegration and…”
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Smad7 restricts melanoma invasion by restoring N-cadherin expression and establishing heterotypic cell-cell interactions in vivo by DiVito, Kyle A., Trabosh, Valerie A., Chen, You-Shin, Chen, Yu, Albanese, Chris, Javelaud, Delphine, Mauviel, Alain, Simbulan-Rosenthal, Cynthia M., Rosenthal, Dean S.

“…Summary The list of transforming growth factor‐beta (TGF‐β)‐related proteins in non‐canonical TGF‐β signaling is growing. Examples include receptor‐Smads…”
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Id3 induces an Elk‐1–caspase‐8‐dependent apoptotic pathway in squamous carcinoma cells by Chen, You‐Shin, Aubee, Joseph, DiVito, Kyle A., Zhou, Hengbo, Zhang, Weiyi, Chou, Fen‐Pi, Simbulan‐Rosenthal, Cynthia M., Rosenthal, Dean S.

“…Inhibitor of differentiation/DNA‐binding (Id) proteins are helix–loop–helix (HLH) transcription factors. The Id protein family (Id1–Id4) mediates tissue…”
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Misregulation of Gene Expression in Primary Fibroblasts Lacking Poly(ADP-Ribose) Polymerase by Simbulan-Rosenthal, Cynthia M., Ly, Danith H., Rosenthal, Dean S., Konopka, Genevieve, Luo, RuiBai, Wang, Zhao-Qi, Schultz, Peter G., Smulson, Mark E.

“…Poly(ADP-ribose)polymerase (PARP) is implicated in the maintenance of genomic integrity, given that inhibition or depletion of this enzyme increases genomic…”
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Reactive Oxygen Species Scavenging Potential Contributes to Hypertrophic Scar Formation by Carney, Bonnie C., Chen, Jason H., Kent, Rhett A., Rummani, Maha, Alkhalil, Abdulnaser, Moffatt, Lauren T., Rosenthal, Dean S., Shupp, Jeffrey W.

“…Reactive oxygen species (ROS) can damage macromolecules if not appropriately neutralized by ROS scavengers. The balance between ROS and ROS scavengers is…”
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Expression of Dominant-negative Fas-associated Death Domain Blocks Human Keratinocyte Apoptosis and Vesication Induced by Sulfur Mustard by Rosenthal, Dean S, Velena, Alfredo, Chou, Feng-Pai, Schlegel, Richard, Ray, Radharaman, Benton, Betty, Anderson, Dana, Smith, William J, Simbulan-Rosenthal, Cynthia M

“…DNA damaging agents up-regulate levels of the Fas receptor or its ligand, resulting in recruitment of Fas-associated death domain (FADD) and autocatalytic…”
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Chromosomal Aberrations in PARP-/- Mice: Genome Stabilization in Immortalized Cells by Reintroduction of Poly(ADP-Ribose) Polymerase cDNA by Simbulan-Rosenthal, Cynthia M., Haddad, Bassem R., Rosenthal, Dean S., Weaver, Zoë, Coleman, Allen, Luo, RuiBai, Young, Hannah M., Wang, Zhao-Qi, Ried, Thomas, Smulson, Mark E.

“…Depletion of poly(ADP-ribose) polymerase (PARP) increases the frequency of recombination, gene amplification, sister chromatid exchanges, and micronuclei…”
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Pigmentation Diathesis of Hypertrophic Scar: An Examination of Known Signaling Pathways to Elucidate the Molecular Pathophysiology of Injury-Related Dyschromia by Carney, Bonnie C, Chen, Jason H, Luker, Jenna N, Alkhalil, Abdulnaser, Jo, Daniel Y, Travis, Taryn E, Moffatt, Lauren T, Simbulan-Rosenthal, Cynthia M, Rosenthal, Dean S, Shupp, Jeffrey W

“…Abstract Hypertrophic scar (HTS) occurs frequently after burn injury. Treatments for some aspects of scar morbidity exist, however, dyspigmentation treatments…”
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Promoter Methylation Status in Pro-opiomelanocortin Does Not Contribute to Dyspigmentation in Hypertrophic Scar by Carney, Bonnie C, Dougherty, Ryan D, Moffatt, Lauren T, Simbulan-Rosenthal, Cynthia M, Shupp, Jeffrey W, Rosenthal, Dean S

“…Abstract Burn injuries frequently result in hypertrophic scars (HTSs), specifically when excision and grafting are delayed due to limited resources or patient…”
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CRISPR-Cas9 Knockdown and Induced Expression of CD133 Reveal Essential Roles in Melanoma Invasion and Metastasis by Simbulan-Rosenthal, Cynthia M., Dougherty, Ryan, Vakili, Sahar, Ferraro, Alexandra M., Kuo, Li-Wei, Alobaidi, Ryyan, Aljehane, Leala, Gaur, Anirudh, Sykora, Peter, Glasgow, Eric, Agarwal, Seema, Rosenthal, Dean S.

“…CD133, known as prominin1, is a penta-span transmembrane glycoprotein presumably a cancer stem cell marker for carcinomas, glioblastomas, and melanomas. We…”
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The E7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosis by STÖPPLER, H, STÖPPLER, M. C, JOHNSON, E, SIMBULAN-ROSENTHAL, C. M, SMULSON, M. E, IYER, S, ROSENTHAL, D. S, SCHLEGEL, R

“…The 'high risk' human papillomaviruses are associated with the development of anogenital carcinomas and their E6 and E7 genes possess immortalizing and…”
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