Search Results - "ROSENBERRY, TERRONE L."

Solvent Deuterium Oxide Isotope Effects on the Reactions of Organophosphorylated Acetylcholinesterase by Rosenberry, Terrone L

“…Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially…”
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Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study by Rosenberry, Terrone L, Brazzolotto, Xavier, Macdonald, Ian R, Wandhammer, Marielle, Trovaslet-Leroy, Marie, Darvesh, Sultan, Nachon, Florian

“…Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic…”
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Structures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site Flexibility by Cheung, Jonah, Gary, Ebony N, Shiomi, Kazuro, Rosenberry, Terrone L

“…Acetylcholinesterase is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system…”
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A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides by Nachon, Florian, Rosenberry, Terrone L, Silman, Israel, Sussman, Joel L

“…Over recent decades, crystallographic software for data processing and structure refinement has improved dramatically, resulting in more accurate and detailed…”
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Oligomer Formation by Amyloid-β42 in a Membrane-Mimicking Environment in Alzheimer's Disease by Rosenberry, Terrone L, Zhou, Huan-Xiang, Stagg, Scott M, Paravastu, Anant K

“…The brains of Alzheimer's disease (AD) patients contain numerous amyloid plaques that are diagnostic of the disease. The plaques are primarily composed of the…”
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Accumulation of Pathological Tau Species and Memory Loss in a Conditional Model of Tauopathy by Berger, Zdenek, Roder, Hanno, Hanna, Amanda, Carlson, Aaron, Rangachari, Vijayaraghavan, Yue, Mei, Wszolek, Zbigniew, Ashe, Karen, Knight, Joshua, Dickson, Dennis, Andorfer, Cathy, Rosenberry, Terrone L, Lewis, Jada, Hutton, Mike, Janus, Christopher

“…Neurofibrillary tangles (NFTs) are a pathological hallmark of Alzheimer's disease and other tauopathies, but recent studies in a conditional mouse model of…”
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Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation by Zheng, Honghua, Liu, Chia-Chen, Atagi, Yuka, Chen, Xiao-Fen, Jia, Lin, Yang, Longyu, He, Wencan, Zhang, Xilin, Kang, Silvia S., Rosenberry, Terrone L., Fryer, John D., Zhang, Yun-Wu, Xu, Huaxi, Bu, Guojun

“…Mutations in triggering receptor expressed on myeloid cells 2 (TREM2), which has been proposed to regulate the inflammatory responses and the clearance of…”
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Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40 by Suire, Caitlin N., Abdul-Hay, Samer O., Sahara, Tomoko, Kang, Dongcheul, Brizuela, Monica K., Saftig, Paul, Dickson, Dennis W., Rosenberry, Terrone L., Leissring, Malcolm A.

“…Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid β-protein (Aβ) and the microtubule-associated protein, tau, and has been…”
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Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-β42 in Alzheimer's disease by Shinohara, Mitsuru, Koga, Shunsuke, Konno, Takuya, Nix, Jeremy, Shinohara, Motoko, Aoki, Naoya, Das, Pritam, Parisi, Joseph E, Petersen, Ronald C, Rosenberry, Terrone L, Dickson, Dennis W, Bu, Guojun

“…Accumulation of amyloid-β peptides is a dominant feature in the pathogenesis of Alzheimer's disease; however, it is not clear how individual amyloid-β species…”
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A common pathway for detergent-assisted oligomerization of Aβ42 by Muhammedkutty, Fidha Nazreen Kunnath, Prasad, Ramesh, Gao, Yuan, Sudarshan, Tarunya Rao, Robang, Alicia S., Watzlawik, Jens O., Rosenberry, Terrone L., Paravastu, Anant K., Zhou, Huan-Xiang

“…Amyloid beta (Aβ) aggregation is a slow process without seeding or assisted nucleation. Sodium dodecyl sulfate (SDS) micelles stabilize Aβ42 small oligomers…”
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Acetylcholinesterase: From 3D structure to function by Dvir, Hay, Silman, Israel, Harel, Michal, Rosenberry, Terrone L., Sussman, Joel L.

“…By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. Acetylcholinesterase is…”
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Rate-limiting step in the decarbamoylation of acetylcholinesterases with large carbamoyl groups by Rosenberry, Terrone L., Cheung, Jonah

“…Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine…”
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Acetylthiocholine Binds to Asp74 at the Peripheral Site of Human Acetylcholinesterase as the First Step in the Catalytic Pathway by Mallender, William D, Szegletes, Tivadar, Rosenberry, Terrone L

“…Studies of ligand binding to acetylcholinesterase (AChE) have demonstrated two sites of interaction. An acyl−enzyme intermediate is formed at the acylation…”
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Probing the Peripheral Site of Human Butyrylcholinesterase by Macdonald, Ian R, Martin, Earl, Rosenberry, Terrone L, Darvesh, Sultan

“…Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as…”
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The Alzheimer's Amyloid-β(1–42) Peptide Forms Off-Pathway Oligomers and Fibrils That Are Distinguished Structurally by Intermolecular Organization by Tay, William M., Huang, Danting, Rosenberry, Terrone L., Paravastu, Anant K.

“…Increasing evidence suggests that soluble aggregates of amyloid-β (Aβ) initiate the neurotoxicity that eventually leads to dementia in Alzheimer's disease…”
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Mechanisms of altered vagal control in heart failure: influence of muscarinic receptors and acetylcholinesterase activity by Dunlap, Mark E, Bibevski, Steve, Rosenberry, Terrone L, Ernsberger, Paul

“…Parasympathetic control of the heart is attenuated in heart failure (HF). We investigated possible mechanisms and sites of altered vagal control in dogs with…”
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VEGF receptor‐1 modulates amyloid β 1–42 oligomer‐induced senescence in brain endothelial cells by Angom, Ramcharan Singh, Wang, Ying, Wang, Enfeng, Pal, Krishnendu, Bhattacharya, Santanu, Watzlawik, Jens O., Rosenberry, Terrone L., Das, Pritam, Mukhopadhyay, Debabrata

“…ABSTRACT Aggregated amyloid β (Aβ) peptides in the Alzheimer's disease (AD) brain are hypothesized to trigger several downstream pathologies, including…”
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Antiparallel β-Sheet Structure within the C-Terminal Region of 42-Residue Alzheimer's Amyloid-β Peptides When They Form 150-kDa Oligomers by Huang, Danting, Zimmerman, Maxwell I., Martin, Patricia K., Nix, A.Jeremy, Rosenberry, Terrone L., Paravastu, Anant K.

“…Understanding the molecular structures of amyloid-β (Aβ) oligomers and underlying assembly pathways will advance our understanding of Alzheimer's disease (AD)…”
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Substrate Binding to the Peripheral Site of Acetylcholinesterase Initiates Enzymatic Catalysis. Substrate Inhibition Arises as a Secondary Effect by Szegletes, Tivadar, Mallender, William D, Thomas, Patrick J, Rosenberry, Terrone L

“…Two sites of ligand interaction in acetylcholinesterase (AChE) were first demonstrated in ligand binding studies and later confirmed by crystallography,…”
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Out-of-Register Parallel β-Sheets and Antiparallel β-Sheets Coexist in 150-kDa Oligomers Formed by Amyloid-β(1–42) by Gao, Yuan, Guo, Cong, Watzlawik, Jens O., Randolph, Peter S., Lee, Elizabeth J., Huang, Danting, Stagg, Scott M., Zhou, Huan-Xiang, Rosenberry, Terrone L., Paravastu, Anant K.

“…We present solid-state NMR measurements of β-strand secondary structure and inter-strand organization within a 150-kDa oligomeric aggregate of the 42-residue…”
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