Search Results - "ROSENBERG, SUSAN M."

Emergence of antibiotic resistance from multinucleated bacterial filaments by Bos, Julia, Zhang, Qiucen, Vyawahare, Saurabh, Rogers, Elizabeth, Rosenberg, Susan M., Austin, Robert H.

“…Bacteria can rapidly evolve resistance to antibiotics via the SOS response, a state of high-activity DNA repair and mutagenesis. We explore here the first…”
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What is mutation? A chapter in the series: How microbes "jeopardize" the modern synthesis by Fitzgerald, Devon M, Rosenberg, Susan M

“…Mutations drive evolution and were assumed to occur by chance: constantly, gradually, roughly uniformly in genomes, and without regard to environmental inputs,…”
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R-loops and nicks initiate DNA breakage and genome instability in non-growing Escherichia coli by Wimberly, Hallie, Shee, Chandan, Thornton, P. C., Sivaramakrishnan, Priya, Rosenberg, Susan M., Hastings, P. J.

“…Double-stranded DNA ends, often from replication, drive genomic instability, yet their origin in non-replicating cells is unknown. Here we show that…”
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Stress-Induced Mutagenesis, Gambler Cells, and Stealth Targeting Antibiotic-Induced Evolution by Pribis, John P, Zhai, Yin, Hastings, P J, Rosenberg, Susan M

“…Mechanisms of evolution and evolution of antibiotic resistance are both fundamental and world health problems. Stress-induced mutagenesis defines mechanisms of…”
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Mutation as a stress response and the regulation of evolvability by Galhardo, Rodrigo S, Hastings, P J, Rosenberg, Susan M

“…Our concept of a stable genome is evolving to one in which genomes are plastic and responsive to environmental changes. Growing evidence shows that a variety…”
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Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks by Mamun, Abu Amar M. Al, Lombardo, Mary-Jane, Shee, Chandan, Lisewski, Andreas M., Gonzalez, Caleb, Lin, Dongxu, Nehring, Ralf B., Saint-Ruf, Claude, Gibson, Janet L., Frisch, Ryan L., Lichtarge, Olivier, Hastings, P. J., Rosenberg, Susan M.

“…Mechanisms of DNA repair and mutagenesis are defined on the basis of relatively few proteins acting on DNA, yet the identities and functions of all proteins…”
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Impact of a stress-inducible switch to mutagenic repair of DNA breaks on mutation in Escherichia coli by Shee, Chandan, Gibson, Janet L., Darrow, Michael C., Gonzalez, Caleb, Rosenberg, Susan M.

“…Basic ideas about the constancy and randomness of mutagenesis that drives evolution were challenged by the discovery of mutation pathways activated by stress…”
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Two Mechanisms Produce Mutation Hotspots at DNA Breaks in Escherichia coli by Shee, Chandan, Gibson, Janet L., Rosenberg, Susan M.

“…Mutation hotspots and showers occur across phylogeny and profoundly influence genome evolution, yet the mechanisms that produce hotspots remain obscure. We…”
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Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance by Fitzgerald, Devon M, Hastings, P.J, Rosenberg, Susan M

“…Genomic instability underlies many cancers and generates genetic variation that drives cancer initiation, progression, and therapy resistance. In contrast with…”
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Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli by Marciano, David C., Wang, Chen, Hsu, Teng-Kuei, Bourquard, Thomas, Atri, Benu, Nehring, Ralf B., Abel, Nicholas S., Bowling, Elizabeth A., Chen, Taylor J., Lurie, Pamela D., Katsonis, Panagiotis, Rosenberg, Susan M., Herman, Christophe, Lichtarge, Olivier

“…Since antibiotic development lags, we search for potential drug targets through directed evolution experiments. A challenge is that many resistance genes hide…”
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Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli by Moore, Jessica M, Correa, Raul, Rosenberg, Susan M, Hastings, P J

“…Bacteria, yeast and human cancer cells possess mechanisms of mutagenesis upregulated by stress responses. Stress-inducible mutagenesis potentially accelerates…”
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Interdependent progression of bidirectional sister replisomes in E. coli by Chen, Po Jui, McMullin, Anna B, Visser, Bryan J, Mei, Qian, Rosenberg, Susan M, Bates, David

“…Bidirectional DNA replication complexes initiated from the same origin remain colocalized in a factory configuration for part or all their lifetimes. However,…”
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A Switch from High-Fidelity to Error-Prone DNA Double-Strand Break Repair Underlies Stress-Induced Mutation by Ponder, Rebecca G., Fonville, Natalie C., Rosenberg, Susan M.

“…Special mechanisms of mutation are induced in microbes under growth-limiting stress causing genetic instability, including occasional adaptive mutations that…”
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Biology before the SOS Response—DNA Damage Mechanisms at Chromosome Fragile Sites by Fitzgerald, Devon M., Rosenberg, Susan M.

“…The Escherichia coli SOS response to DNA damage, discovered and conceptualized by Evelyn Witkin and Miroslav Radman, is the prototypic DNA-damage stress…”
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Stress-Induced β-Lactam Antibiotic Resistance Mutation and Sequences of Stationary-Phase Mutations in the Escherichia coli Chromosome by PETROSINO, Joseph F, GALHARDO, Rodrigo S, MORALES, Liza D, ROSENBERG, Susan M

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Life, the genome and everything by Rosenberg, Susan M

“…In this issue of the , N. J. Bonde, E. A. Wood, K. S. Myers, M. Place, J. L. Keck, and M. M. Cox (J Bacteriol 205:e00184-23, 2023,…”
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Role of RecA and the SOS response in thymineless death in Escherichia coli by Fonville, Natalie C, Bates, David, Hastings, P J, Hanawalt, Philip C, Rosenberg, Susan M

“…Thymineless death (TLD) is a classic and enigmatic phenomenon, documented in bacterial, yeast, and human cells, whereby cells lose viability rapidly when…”
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Engineered proteins detect spontaneous DNA breakage in human and bacterial cells by Shee, Chandan, Cox, Ben D, Gu, Franklin, Luengas, Elizabeth M, Joshi, Mohan C, Chiu, Li-Ya, Magnan, David, Halliday, Jennifer A, Frisch, Ryan L, Gibson, Janet L, Nehring, Ralf Bernd, Do, Huong G, Hernandez, Marcos, Li, Lei, Herman, Christophe, Hastings, P J, Bates, David, Harris, Reuben S, Miller, Kyle M, Rosenberg, Susan M

“…Spontaneous DNA breaks instigate genomic changes that fuel cancer and evolution, yet direct quantification of double-strand breaks (DSBs) has been limited…”
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On the mechanism of gene amplification induced under stress in Escherichia coli by Slack, Andrew, Thornton, P C, Magner, Daniel B, Rosenberg, Susan M, Hastings, P J

“…Gene amplification is a collection of processes whereby a DNA segment is reiterated to multiple copies per genome. It is important in carcinogenesis and…”
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Two mechanisms of chromosome fragility at replication-termination sites in bacteria by Mei, Qian, Fitzgerald, Devon M, Liu, Jingjing, Xia, Jun, Pribis, John P, Zhai, Yin, Nehring, Ralf B, Paiano, Jacob, Li, Heyuan, Nussenzweig, Andre, Hastings, P J, Rosenberg, Susan M

“…Chromosomal fragile sites are implicated in promoting genome instability, which drives cancers and neurological diseases. Yet, the causes and mechanisms of…”
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