Search Results - "ROSENBERG, L. E"

Salicylic acid-based poly(anhydride esters) for control of biofilm formation in Salmonella enterica serovar Typhimurium by Rosenberg, L.E, Carbone, A.L, Römling, U, Uhrich, K.E, Chikindas, M.L

“…Bacterial biofilms generally are more resistant to stresses as compared with free planktonic cells. Therefore, the discovery of antimicrobial stress factors…”
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The physician-scientist: an essential--and fragile--link in the medical research chain by Rosenberg, L E

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Survey of Amino-Terminal Proteolytic Cleavage Sites in Mitochondrial Precursor Proteins: Leader Peptides Cleaved by Two Matrix Proteases Share a Three-Amino Acid Motif by Hendrick, Joseph P., Hodges, Peter E., Rosenberg, Leon E.

“…We have compiled sequences of precursor proteins for 50 mitochondrial proteins for which the mature amino terminus has been determined by amino acid sequence…”
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Young physician-scientists: internal Medicine's challenge by Rosenberg, L E

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Rat cystathionine beta-synthase. Gene organization and alternative splicing by SWAROOP, M, BRADLEY, K, OHURA, T, TAHARA, T, ROPER, M. D, ROSENBERG, L. E, KRAUS, J. P

“…We elucidated the structure and alternative splicing patterns of the rat cystathionine beta-synthase gene. The gene is 20-25 kilobase pairs long, and its…”
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Legacies of Garrod’s brilliance. One hundred years—and counting by Rosenberg, L. E.

“…Summary One hundred years ago—in 1908—Archibald Garrod delivered his four Croonian Lectures. In these formerly forgotten, but now famous, dissertations, Garrod…”
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Mistargeting of Peroxisomal L-Alanine:Glyoxylate Aminotransferase to Mitochondria in Primary Hyperoxaluria Patients Depends Upon Activation of a Cryptic Mitochondrial Targeting Sequence by a Point Mutation by Purdue, P. E., Allsop, J., Isaya, G., Rosenberg, L. E., Danpure, C. J.

“…In approximately one-third of primary hyperoxaluria type 1 patients, disease is associated with a unique protein sorting defect in which hepatic…”
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Cleavage of Precursors by the Mitochondrial Processing Peptidase Requires a Compatible Mature Protein or an Intermediate Octapeptide by Isaya, Grazia, Kalousek, Frantisek, Fenton, Wayne A., Rosenberg, Leon E.

“…Many precursors of mitochondrial proteins are processed in two successive steps by independent matrix peptidases (MPP and MIP), whereas others are cleaved in a…”
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Two Mitochondrial Matrix Proteases Act Sequentially in the Processing of Mammalian Matrix Enzymes by Kalousek, Frantisek, Hendrick, Joseph P., Rosenberg, Leon E.

“…The imported precursors of the mammalian matrix enzymes malate dehydrogenase [(S)-malate:NAD+ oxidoreductase, EC 1.1.1.37] and ornithine transcarbamylase…”
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Gene Therapist, Heal Thyself by Rosenberg, Leon E., Schechter, Alan N.

“…At present, the ethos of the new field of gene therapy is clearly not working. Despite repeated claims of benefit or even cure, no single unequivocal instance…”
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GroEL, GroES, and ATP-dependent folding and spontaneous assembly of ornithine transcarbamylase by XIANXIAN ZHENG, ROSENBERG, L. E, KALOUSEK, F, FENTON, W. A

“…When purified rat liver ornithine transcarbamylase (OTC), a trimer of 36 kDa subunits, was denatured in 6 M guanidine hydrochloride and then diluted…”
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The General Mitochondrial Matrix Processing Protease from Rat Liver: Structural Characterization of the Catalytic Subunit by Kleiber, Jorg, Kalousek, Frantisek, Swaroop, Manju, Rosenberg, Leon E.

“…A critical step in the import of nuclear-encoded precursor proteins into mitochondria involves proteolytic cleavage of their amino-terminal leader peptides by…”
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Rat liver mitochondrial intermediate peptidase (MIP): purification and initial characterization by Kalousek, F., Isaya, G., Rosenberg, L.E.

“…A number of nuclearly encoded mitochondrial protein precursors that are transported into the matrix and inner membrane are cleaved in two sequential steps by…”
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A leader peptide is sufficient to direct mitochondrial import of a chimeric protein by Horwich, A.L., Kalousek, F., Mellman, I., Rosenberg, L.E.

“…Most mitochondrial proteins are encoded in the nucleus and synthesized in the cytoplasm as larger precursors containing NH2‐terminal ‘leader’ peptides. To test…”
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Human cystathionine beta-synthase cDNA: sequence, alternative splicing and expression in cultured cells by Kraus, J P, Le, K, Swaroop, M, Ohura, T, Tahara, T, Rosenberg, L E, Roper, M D, Kozich, V

“…Cystathionine beta-synthase (CBS) deficiency is the major cause of homocystinuria in humans. The most frequent symptoms of homocystinuria include: dislocated…”
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Rat liver mitochondrial processing peptidase. Both alpha- and beta-subunits are required for activity by SAAVEDRA-ALANIS, V. M, RYSAVY, P, ROSENBERG, L. E, KALOUSEK, F

“…Most nuclearly encoded mitochondrial proteins are synthesized with an amino-terminal leader peptide that is cleaved by the mitochondrial processing peptidase…”
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Amino-terminal octapeptides function as recognition signals for the mitochondrial intermediate peptidase by ISAYA, G, KALOUSEK, F, ROSENBERG, L. E

“…We have shown previously that cleavage of a number of precursors by the mitochondrial processing peptidase (MPP) requires an intermediate octapeptide…”
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Sequence Analysis of Rat Mitochondrial Intermediate Peptidase: Similarity to Zinc Metallopeptidases and to a Putative Yeast Homologue by Isaya, Grazia, Kalousek, Frantisek, Rosenberg, Leon E.

“…Proteolytic removal of amino-terminal octapeptides from mitochondrial intermediate proteins is a required step for a subgroup of nuclear-encoded mitochondrial…”
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The β Subunit of the Mitochondrial Processing Peptidase From Rat Liver: Cloning and Sequencing of a cDNA and Comparison With a Proposed Family of Metallopeptidases by Paces, Vaclav, Rosenberg, Leon E., Fenton, Wayne A., Kalousek, Frantisek

“…Most nuclearly encoded mitochondrial proteins are synthesized with amino-terminal leader peptides that are removed by the mitochondrial processing peptidase…”
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The precursor of the biotin-binding subunit of mammalian propionyl-CoA carboxylase can be translocated into mitochondria as apo- or holoprotein by TARONI, F, ROSENBERG, L. E

“…We have investigated the biogenesis of the biotin-binding alpha-subunit of propionyl-CoA carboxylase (alpha PCC) in cultured Buffalo rat liver cells. Cells…”
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