Search Results - "ROSEN, Seymour"

Experimental ischemia–reperfusion: biases and myths—the proximal vs. distal hypoxic tubular injury debate revisited by Heyman, Samuel N., Rosenberger, Christian, Rosen, Seymour

“…Although the understanding of processes associated with hypoxic tubular cell injury has remarkably improved, controversies remain regarding the appropriateness…”
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Data retrieval from archival renal biopsies using nonlinear microscopy by Cahill, Lucas C, Yoshitake, Tadayuki, Rosen, Milan, Weber, Timothy D, Fujimoto, James G, Rosen, Seymour

“…Thorough examination of renal biopsies may improve understanding of renal disease. Imaging of renal biopsies with fluorescence nonlinear microscopy (NLM) and…”
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Podocyte-Specific Loss of Functional MicroRNAs Leads to Rapid Glomerular and Tubular Injury by HO, Jacqueline, KAR HUI NG, ROSEN, Seymour, DOSTAL, Ales, GREGORY, Richard I, KREIDBERG, Jordan A

“…MicroRNAs (miRNAs) are in a class of endogenous, small, noncoding RNAs that exert their effects through posttranscriptional repression of specific target…”
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Reactive Oxygen Species and the Pathogenesis of Radiocontrast-Induced Nephropathy by Heyman, Samuel N, Rosen, Seymour, Khamaisi, Mogher, Idée, Jean-Marc, Rosenberger, Christian

“…Experimental findings in vitro and in vivo illustrate enhanced hypoxia and the formation of reactive oxygen species (ROS) within the kidney following the…”
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Acute Tubular Necrosis Is a Syndrome of Physiologic and Pathologic Dissociation by ROSEN, Seymour, STILLMAN, Isaac E

“…Acute tubular necrosis (ATN) is a syndrome of intrinsic renal failure secondary to ischemic or toxic insults. The histopathologic findings of ATN are…”
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Renal Parenchymal Hypoxia, Hypoxia Adaptation, and the Pathogenesis of Radiocontrast Nephropathy by Heyman, Samuel N, Rosen, Seymour, Rosenberger, Christian

“…Renal parenchymal Po(2) declines after the administration of iodinated radiocontrast agents, reaching critically low levels of approximately 10 mmHg in…”
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Near-drowning: new perspectives for human hypoxic acute kidney injury by Heyman, Samuel N, Gorelik, Yuri, Zorbavel, Danny, Rosenberger, Christian, Abassi, Zaid, Rosen, Seymour, Khamaisi, Mogher

“…Abstract Concepts regarding hypoxic acute kidney injury (AKI) are derived from widely used warm ischemia-reflow (WIR) models, characterized by extensive…”
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Reconfiguration and loss of peritubular capillaries in chronic kidney disease by Gaupp, Charlotte, Schmid, Benjamin, Tripal, Philipp, Edwards, Aurélie, Daniel, Christoph, Zimmermann, Stefan, Goppelt-Struebe, Margarete, Willam, Carsten, Rosen, Seymour, Schley, Gunnar

“…Functional and structural alterations of peritubular capillaries (PTCs) are a major determinant of chronic kidney disease (CKD). Using a software-based…”
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Why Is Diabetes Mellitus a Risk Factor for Contrast-Induced Nephropathy? by Khamaisi, Mogher, Rosen, Seymour, Rosenberger, Christian, Heyman, Samuel N.

“…Contrast-induced nephropathy (CIN) remains a leading cause of iatrogenic acute kidney injury, as the usage of contrast media for imaging and intravascular…”
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Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology by Schley, Gunnar, Jordan, Jutta, Ellmann, Stephan, Rosen, Seymour, Eckardt, Kai-Uwe, Uder, Michael, Willam, Carsten, Bäuerle, Tobias

“…In human chronic kidney disease (CKD) the extent of renal tubulointerstitial fibrosis correlates with progressive loss of renal function. However, fibrosis can…”
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Architecture of the human renal inner medulla and functional implications by Wei, Guojun, Rosen, Seymour, Dantzler, William H, Pannabecker, Thomas L

“…The architecture of the inner stripe of the outer medulla of the human kidney has long been known to exhibit distinctive configurations; however, inner…”
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Mutations in KIRREL1, a slit diaphragm component, cause steroid-resistant nephrotic syndrome by Solanki, Ashish K, Widmeier, Eugen, Arif, Ehtesham, Sharma, Shailza, Daga, Ankana, Srivastava, Pankaj, Kwon, Sang-Ho, Hugo, Hannah, Nakayama, Makiko, Mann, Nina, Majmundar, Amar J, Tan, Wei, Gee, Heon Yung, Sadowski, Caroline E, Rinat, Choni, Becker-Cohen, Rachel, Bergmann, Carsten, Rosen, Seymour, Somers, Michael, Shril, Shirlee, Huber, Tobias B, Mane, Shrikant, Hildebrandt, Friedhelm, Nihalani, Deepak

“…Steroid-resistant nephrotic syndrome is a frequent cause of chronic kidney disease almost inevitably progressing to end-stage renal disease. More than 58…”
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Hypoxia-inducible Transcription Factors Stabilization in the Thick Ascending Limb Protects against Ischemic Acute Kidney Injury by SCHLEY, Gunnar, KLANKE, Bernd, MAXWELL, Patrick H, WILLAM, Carsten, SCHÖDEL, Johannes, FORSTREUTER, Frauke, SHUKLA, Deepa, KURTZ, Armin, AMANN, Kerstin, WIESENER, Michael S, ROSEN, Seymour, ECKARDT, Kai-Uwe

“…Hypoxia-inducible transcription factors (HIF) protect cells against oxygen deprivation, and HIF stabilization before ischemia mitigates tissue injury. Because…”
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Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia by Manoli, Irini, Sysol, Justin R., Li, Lingli, Houillier, Pascal, Garone, Caterina, Wang, Cindy, Zerfas, Patricia M., Cusmano-Ozog, Kristina, Young, Sarah, Trivedi, Niraj S., Cheng, Jun, Sloan, Jennifer L., Chandler, Randy J., Abu-Asab, Mones, Tsokos, Maria, Elkahloun, Abdel G., Rosen, Seymour, Enns, Gregory M., Berry, Gerard T., Hoffmann, Victoria, DiMauro, Salvatore, Schnermann, Jurgen, Venditti, Charles P.

“…Isolated methylmalonic acidemia (MMA), caused by deficiency of the mitochondrial enzyme methylmalonyl-CoA mutase (MUT), is often complicated by end stage renal…”
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Correction: Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology by Schley, Gunnar, Jordan, Jutta, Ellmann, Stephan, Rosen, Seymour, Eckardt, Kai-Uwe, Uder, Michael, Willam, Carsten, Bäuerle, Tobias

“…[This corrects the article DOI: 10.1371/journal.pone.0200259.]…”
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Renal Medullary and Cortical Correlates in Fibrosis, Epithelial Mass, Microvascularity, and Microanatomy Using Whole Slide Image Analysis Morphometry by Farris, Alton B, Ellis, Carla L, Rogers, Thomas E, Lawson, Diane, Cohen, Cynthia, Rosen, Seymour

“…Renal tubulointerstitial injury often leads to interstitial fibrosis and tubular atrophy (IF/TA). IF/TA is typically assessed in the renal cortex and can be…”
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RENAL PARENCHYMAL OXYGENATION AND HYPOXIA ADAPTATION IN ACUTE KIDNEY INJURY by Rosenberger, Christian, Rosen, Seymour, Heyman, Samuel N

“…SUMMARY 1 The pathogenesis of acute kidney injury (AKI), formally termed acute tubular necrosis, is complex and, phenotypically, may range from functional…”
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Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor by Khamaisi, Mogher, Toukan, Hala, Axelrod, Jonathan H, Rosenberger, Christian, Skarzinski, Galia, Shina, Ahuva, Meidan, Rina, Koesters, Robert, Rosen, Seymour, Walkinshaw, Gail, Mimura, Imari, Nangaku, Masaomi, Heyman, Samuel N

“…Renal endothelin-converting enzyme (ECE)-1 is induced in experimental diabetes and following radiocontrast administration, conditions characterized by renal…”
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The pathology of eclampsia: An autopsy series by Hecht, Jonathan L., Ordi, Jaume, Carrilho, Carla, Ismail, Mamudo R., Zsengeller, Zsuzsanna K., Karumanchi, S. Ananth, Rosen, Seymour

“…Objective: We describe the main lesions in the liver, brain, and kidney from autopsies of women who died of eclampsia and characterize the endothelial injury…”
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Hypoxia of the Renal Medulla — Its Implications for Disease by Brezis, Mayer, Rosen, Seymour

“…In land mammals, a major task of the kidney is to reabsorb water to allow survival in a dry environment. Water conservation is enhanced by the renal medulla,…”
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