Search Results - "ROSEN, Michael"

Mechanistic dissection of increased enzymatic rate in a phase-separated compartment by Peeples, William, Rosen, Michael K.

“…Biomolecular condensates concentrate macromolecules into discrete cellular foci without an encapsulating membrane. Condensates are often presumed to increase…”
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Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins by Lin, Yuan, Protter, David S.W., Rosen, Michael K., Parker, Roy

“…Eukaryotic cells possess numerous dynamic membrane-less organelles, RNP granules, enriched in RNA and RNA-binding proteins containing disordered regions. We…”
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A framework for understanding the functions of biomolecular condensates across scales by Lyon, Andrew S., Peeples, William B., Rosen, Michael K.

“…Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in the cytoplasm and on membranes. They are also implicated in a wide…”
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Microplastics in Lake Mead National Recreation Area, USA: Occurrence and biological uptake by Baldwin, Austin K, Spanjer, Andrew R, Rosen, Michael R, Thom, Theresa

“…Microplastics are an environmental contaminant of growing concern, but there is a lack of information about microplastic distribution, persistence,…”
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Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs by Lin, Yuan, Currie, Simon L., Rosen, Michael K.

“…Liquid–liquid phase separation (LLPS) is thought to contribute to the establishment of many biomolecular condensates, eukaryotic cell structures that…”
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Phase transitions of multivalent proteins can promote clustering of membrane receptors by Banjade, Sudeep, Rosen, Michael K

“…Clustering of proteins into micrometer-sized structures at membranes is observed in many signaling pathways. Most models of clustering are specific to…”
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Who's In and Who's Out—Compositional Control of Biomolecular Condensates by Ditlev, Jonathon A., Case, Lindsay B., Rosen, Michael K.

“…Biomolecular condensates are two- and three-dimensional compartments in eukaryotic cells that concentrate specific collections of molecules without an…”
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Inflammatory Bowel Disease in Children and Adolescents by Rosen, Michael J, Dhawan, Ashish, Saeed, Shehzad A

“…The inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn disease, are chronic inflammatory disorders of the gastrointestinal tract most…”
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Regulation of Transmembrane Signaling by Phase Separation by Case, Lindsay B, Ditlev, Jonathon A, Rosen, Michael K

“…Cell surface transmembrane receptors often form nanometer- to micrometer-scale clusters to initiate signal transduction in response to environmental cues…”
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Biomolecular condensates: organizers of cellular biochemistry by Banani, Salman F., Lee, Hyun O., Hyman, Anthony A., Rosen, Michael K.

“…Key Points In addition to canonical membrane-bound organelles, eukaryotic cells contain numerous membraneless compartments, or biomolecular condensates, that…”
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Stoichiometry controls activity of phase-separated clusters of actin signaling proteins by Case, Lindsay B, Zhang, Xu, Ditlev, Jonathon A, Rosen, Michael K

“…Biomolecular condensates concentrate macromolecules into foci without a surrounding membrane. Many condensates appear to form through multivalent interactions…”
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Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein by Pak, Chi W., Kosno, Martyna, Holehouse, Alex S., Padrick, Shae B., Mittal, Anuradha, Ali, Rustam, Yunus, Ali A., Liu, David R., Pappu, Rohit V., Rosen, Michael K.

“…Liquid-liquid phase separation, driven by collective interactions among multivalent and intrinsically disordered proteins, is thought to mediate the formation…”
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DADA2: High-resolution sample inference from Illumina amplicon data by Callahan, Benjamin J, McMurdie, Paul J, Rosen, Michael J, Han, Andrew W, Johnson, Amy Jo A, Holmes, Susan P

“…DADA2 is an open-source software package that denoises and removes sequencing errors from Illumina amplicon sequence data to distinguish microbial sample…”
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New Role for Fatty Acid Receptor Regulation of Immune Cells to Control Intestinal Inflammation by Rosen, Michael J.

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Expertise-Based Intuition and Decision Making in Organizations by Salas, Eduardo, Rosen, Michael A., DiazGranados, Deborah

“…There has been a growing popular fascination with how experts make rapid and effective decisions. This interest has been paralleled in various scientific…”
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Organization of Chromatin by Intrinsic and Regulated Phase Separation by Gibson, Bryan A., Doolittle, Lynda K., Schneider, Maximillian W.G., Jensen, Liv E., Gamarra, Nathan, Henry, Lisa, Gerlich, Daniel W., Redding, Sy, Rosen, Michael K.

“…Eukaryotic chromatin is highly condensed but dynamically accessible to regulation and organized into subdomains. We demonstrate that reconstituted chromatin…”
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Teamwork in Healthcare: Key Discoveries Enabling Safer, High-Quality Care by Rosen, Michael A., DiazGranados, Deborah, Dietz, Aaron S., Benishek, Lauren E., Thompson, David, Pronovost, Peter J., Weaver, Sallie J.

“…Few industries match the scale of health care. In the United States alone, an estimated 85% of the population has at least 1 health care encounter annually and…”
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Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins by Harmon, Tyler S, Holehouse, Alex S, Rosen, Michael K, Pappu, Rohit V

“…Phase transitions of linear multivalent proteins control the reversible formation of many intracellular membraneless bodies. Specific non-covalent crosslinks…”
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Compositional Control of Phase-Separated Cellular Bodies by Banani, Salman F., Rice, Allyson M., Peeples, William B., Lin, Yuan, Jain, Saumya, Parker, Roy, Rosen, Michael K.

“…Cellular bodies such as P bodies and PML nuclear bodies (PML NBs) appear to be phase-separated liquids organized by multivalent interactions among proteins and…”
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Transversus abdominis muscle release: a novel approach to posterior component separation during complex abdominal wall reconstruction by Novitsky, Yuri W., M.D, Elliott, Heidi L., M.D, Orenstein, Sean B., M.D, Rosen, Michael J., M.D

“…Abstract Background Several modifications of the classic retromuscular Stoppa technique to facilitate dissection beyond the lateral border of the rectus sheath…”
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