Effect of long-cycle structured intermittent versus continuous HAART on quality of life in patients with chronic HIV infection

To examine the effect of repeated, long-cycle structured intermittent versus continuous HAART on health-related quality of life (HRQL) and symptom distress in patients with chronic HIV infection and plasma HIV RNA of less than 50 copies/ml. Prospective survey of adult patients (n = 46) enrolled in a...

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Published in:	AIDS (London) Vol. 20; no. 6; pp. 837 - 845
Main Authors:	POWERS, April E, MARDEN, Susan F, ROSE MCCONNELL, L. C. D. R, LEIDY, Nancy K, CAMPBELL, Colleen M, SOEKEN, Karen L, BARKER, Chris, DAVEY, Richard T, DYBUL, Mark R
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 04-04-2006
Subjects:	Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active - adverse effects Antiretroviral Therapy, Highly Active - methods Antiviral agents Biological and medical sciences Chronic Disease Drug Administration Schedule Female Health Status Indicators HIV Infections - drug therapy HIV Infections - psychology HIV Infections - rehabilitation Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Middle Aged Pharmacology. Drug treatments Prospective Studies Psychometrics Quality of Life Severity of Illness Index Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Infection Immunopathology Chemotherapy Chronic Treatment Intermittent Viral disease Antiviral AIDS Immune deficiency Comparative study Quality of life
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Summary:	To examine the effect of repeated, long-cycle structured intermittent versus continuous HAART on health-related quality of life (HRQL) and symptom distress in patients with chronic HIV infection and plasma HIV RNA of less than 50 copies/ml. Prospective survey of adult patients (n = 46) enrolled in a randomized clinical trial evaluating intermittent versus continuous HAART on immunological and virologic parameters. Patients (n = 23) randomized to structured intermittent therapy received serial cycles of 4 weeks on/8 weeks off HAART. HRQL was measured by the physical and mental health summary scores of the Medical Outcomes Study HIV Health Survey (MOS-HIV). Symptom distress was measured by the Symptom Distress Scale. Patients completed initial questionnaires prior to randomization and at weeks 4, 12, and 40 of the trial via a touch screen computer in an outpatient clinic. Baseline demographic and clinical characteristics were equivalent in both treatment groups. Although the mental health summary score declined significantly over time for the structured intermittent group, linear mixed modeling ANOVA indicated no significant difference across time for MOS-HIV summary and Symptom Distress Scale scores between the two treatment arms. In this small sample, repeated long-cycle structured intermittent therapy may not provide HRQL or symptom distress advantage compared to continuous HAART in patients with chronic HIV infection over 10 months of treatment. Further research in a heterogenous chronic HIV population and longer follow-up period is warranted.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0269-9370 1473-5571
DOI:	10.1097/01.aids.0000218547.39339.13