Search Results - "ROSE, F. R. A. J"

The electrospinning of a thermo-responsive polymer with peptide conjugates for phenotype support and extracellular matrix production of therapeutically relevant mammalian cells by Ruiter, F A A, Sidney, L E, Kiick, K L, Segal, J I, Alexander, C, Rose, F R A J

“…Current cell expansion methods for tissue engineering and regenerative medicine applications rely on the use of enzymatic digestion passaging and 2D platforms…”
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Analysis of sintered polymer scaffolds using concomitant synchrotron computed tomography and in situ mechanical testing by Dhillon, A., Schneider, P., Kuhn, G., Reinwald, Y., White, L. J., Levchuk, A., Rose, F. R. A. J., Müller, R., Shakesheff, K. M., Rahman, C. V.

“…The mechanical behaviour of polymer scaffolds plays a vital role in their successful use in bone tissue engineering. The present study utilised novel sintered…”
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Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds by Morris, G E, Bridge, J C, Eltboli, O M I, Lewis, M P, Knox, A J, Aylott, J W, Brightling, C E, Ghaemmaghami, A M, Rose, F R A J

“…Human airway smooth muscle (HASM) contraction plays a central role in regulating airway resistance in both healthy and asthmatic bronchioles. In vitro studies…”
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Growth-induced buckling of an epithelial layer by Nelson, M. R., Howard, D., Jensen, O. E., King, J. R., Rose, F. R. A. J., Waters, S. L.

“…We use a proof-of-concept experiment and two mathematical models to explore growth-induced tissue buckling, as may occur in colorectal crypt formation. Our…”
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Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease by Cunliffe, R N, Rose, F R A J, Keyte, J, Abberley, L, Chan, W C, Mahida, Y R

“…BACKGROUND AND AIMS Intestinal epithelial cell derived antimicrobial peptides of the defensin family may play a major role in host defence against…”
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Hydrogels derived from demineralized and decellularized bone extracellular matrix by Sawkins, M.J., Bowen, W., Dhadda, P., Markides, H., Sidney, L.E., Taylor, A.J., Rose, F.R.A.J., Badylak, S.F., Shakesheff, K.M., White, L.J.

“…The extracellular matrix (ECM) of mammalian tissues has been isolated, decellularized and utilized as a scaffold to facilitate the repair and reconstruction of…”
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Tracking large solid constructs suspended in a rotating bioreactor: A combined experimental and theoretical study by Cummings, L.J., Sawyer, N.B.E., Morgan, S.P., Rose, F.R.A.J., Waters, S.L.

“…We present a combined experimental and theoretical study of the trajectory of a large solid cylindrical disc suspended within a fluid‐filled rotating…”
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Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa by Cunliffe, R N, Kamal, M, Rose, F R A J, James, P D, Mahida, Y R

“…Background/Aims: The normal intestinal epithelium is increasingly being recognised as an important component of the mucosal innate protection against…”
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Tissue growth in a rotating bioreactor. Part I: mechanical stability by Waters, S. L., Cummings, L. J., Shakesheff, K. M., Rose, F. R. A. J.

“…We develop mathematical models to provide insights into the morphology of a tissue construct formed from a single-cell suspension in culture media, within a…”
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A design of experiments approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies by Ruiter, F A A, Alexander, C, Rose, F R A J, Segal, J I

“…Electrospun fibrous materials have increasing applications in regenerative medicine due to the similarity of fibre constructs to the morphology of certain…”
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In situ monitoring of 3D in vitro cell aggregation using an optical imaging system by Sawyer, N.B.E, Worrall, L.K, Crowe, J.A, Waters, S.L, Shakesheff, K.M, Rose, F.R.A.J, Morgan, S.P

“…Bioreactor systems that maintain cells and tissues in suspension are increasingly popular for culturing 3D constructs to avoid the loss of in vivo cell…”
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Potential Role of Epithelial Cell-Derived Histone H1 Proteins in Innate Antimicrobial Defense in the Human Gastrointestinal Tract by ROSE, F. R. A. J, BAILEY, K, KEYTE, J. W, CHAN, W. C, GREENWOOD, D, MAHIDA, Y. R

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model by Smith, E.L., Kanczler, J.M., Gothard, D., Roberts, C.A., Wells, J.A., White, L.J., Qutachi, O., Sawkins, M.J., Peto, H., Rashidi, H., Rojo, L., Stevens, M.M., El Haj, A.J., Rose, F.R.A.J., Shakesheff, K.M., Oreffo, R.O.C.

“…[Display omitted] Current clinical treatments for skeletal conditions resulting in large-scale bone loss include autograft or allograft, both of which have…”
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Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model by Smith, E.L., Kanczler, J.M., Gothard, D., Roberts, C.A., Wells, J.A., White, L.J., Qutachi, O., Sawkins, M.J., Peto, H., Rashidi, H., Rojo, L., Stevens, M.M., El Haj, A.J., Rose, F.R.A.J., Shakesheff, K.M., Oreffo, R.O.C.

“…[Display omitted] There is an unmet need for improved, effective tissue engineering strategies to replace or repair bone damaged through disease or injury…”
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Seeding cells into needled felt scaffolds for tissue engineering applications by Unsworth, J. M., Rose, F. R. A. J., Wright, E., Scotchford, C. A., Shakesheff, K. M.

“…Tissue engineering methods are under development that will enable the repair or replacement of a variety of tissues, including articular cartilage and bone. To…”
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The effect of anisotropic architecture on cell and tissue infiltration into tissue engineering scaffolds by Silva, M.M.C.G., Cyster, L.A., Barry, J.J.A., Yang, X.B., Oreffo, R.O.C., Grant, D.M., Scotchford, C.A., Howdle, S.M., Shakesheff, K.M., Rose, F.R.A.J.

“…A common phenomenon in tissue engineering is rapid tissue formation on the outer edge of the scaffold which restricts cell penetration and nutrient exchange to…”
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Chemistry of Polymer and Ceramic-Based Injectable Scaffolds and Their Applications in Regenerative Medicine by Rahman, C. V, Saeed, A, White, L. J, Gould, T. W. A, Kirby, G. T. S, Sawkins, M. J, Alexander, C, Rose, F. R. A. J, Shakesheff, K. M

“…Injectable scaffolds are a class of materials that stimulate the regeneration of functional tissue within the body. These materials are attracting interest in…”
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The influence of dispersant concentration on the pore morphology of hydroxyapatite ceramics for bone tissue engineering by Cyster, L.A., Grant, D.M., Howdle, S.M., Rose, F.R.A.J., Irvine, D.J., Freeman, D., Scotchford, C.A., Shakesheff, K.M.

“…There is a clinical need for synthetic scaffolds that will promote bone regeneration. Important factors include obtaining an optimal porosity and size of…”
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A novel electrospun biphasic scaffold provides optimal three-dimensional topography for in vitro co-culture of airway epithelial and fibroblast cells by Morris, G E, Bridge, J C, Brace, L A, Knox, A J, Aylott, J W, Brightling, C E, Ghaemmaghami, A M, Rose, F R A J

“…Conventional airway in vitro models focus upon the function of individual structural cells cultured in a two-dimensional monolayer, with limited…”
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Cell adhesion and mechanical properties of a flexible scaffold for cardiac tissue engineering by Hidalgo-Bastida, L.A., Barry, J.J.A., Everitt, N.M., Rose, F.R.A.J., Buttery, L.D., Hall, I.P., Claycomb, W.C., Shakesheff, K.M.

“…Cardiac tissue engineering is focused on obtaining functional cardiomyocyte constructs to provide an alternative to cellular cardiomyoplasty. Mechanical…”
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