Search Results - "ROSA, J.‐P."

Mitogen‐activated protein kinases in hemostasis and thrombosis by ADAM, F., KAUSKOT, A., ROSA, J.‐P., BRYCKAERT, M.

“…The mitogen‐activated protein (MAP) kinases ERK2, p38 and JNK1 are present in platelets and are activated by various stimuli, such as thrombin, collagen, von…”
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The effects of lichen cover upon the rate of solutional weathering of limestone by McIlroy de la Rosa, J.P., Warke, P.A., Smith, B.J.

“…The contribution of lichens to the biomodification of limestone surfaces is an area of conflict within bioweathering studies, with some researchers suggesting…”
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Aqueous two-phase extraction as a platform in the biomanufacturing industry: Economical and environmental sustainability by Rosa, P.A.J., Azevedo, A.M., Sommerfeld, S., Bäcker, W., Aires-Barros, M.R.

“…The biotech industry is, nowadays, facing unparalleled challenges due to the enhanced demand for biotechnology-based human therapeutic products, such as…”
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Continuous aqueous two-phase extraction of human antibodies using a packed column by Rosa, P.A.J., Azevedo, A.M., Sommerfeld, S., Bäcker, W., Aires-Barros, M.R.

“…► We evaluated the performance of a pilot scale packed column for the continuous extraction of IgG. ► Aqueous two-phase systems of PEG and salt enable IgG…”
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Application of aqueous two-phase systems to antibody purification: A multi-stage approach by Rosa, P.A.J., Azevedo, A.M., Sommerfeld, S., Mutter, M., Aires-Barros, M.R., Bäcker, W.

“…The single-stage equilibrium aqueous two-phase extraction (ATPE) of human antibodies from a Chinese hamster ovary (CHO) cells supernatant was investigated. The…”
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Probing platelet factor 4 α‐granule targeting by Briquet‐Laugier, V., Lavenu‐Bombled, C., Schmitt, A., Leboeuf, M., Uzan, G., Dubart‐Kupperschmitt, A., Rosa, J.‐P.

“…The storage mechanism of endogenous secretory proteins in megakaryocyte α‐granules is poorly understood. We have elected to study the granule storage of…”
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Affinity partitioning of human antibodies in aqueous two-phase systems by Rosa, P.A.J., Azevedo, A.M., Ferreira, I.F., de Vries, J., Korporaal, R., Verhoef, H.J., Visser, T.J., Aires-Barros, M.R.

“…The partitioning of human immunoglobulin (IgG) in a polymer–polymer and polymer–salt aqueous two-phase system (ATPS) in the presence of several functionalised…”
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Type of volcanoes hosting the massive sulfide deposits of the Iberian Pyrite Belt by Rosa, Carlos J.P., McPhie, Jocelyn, Relvas, Jorge M.R.S.

“…The Volcanic Sedimentary Complex (VSC) of the Iberian Pyrite Belt (IPB) in southern Portugal and Spain, comprises an Upper Devonian to Lower Carboniferous…”
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Downstream processing of antibodies: Single-stage versus multi-stage aqueous two-phase extraction by Rosa, P.A.J., Azevedo, A.M., Ferreira, I.F., Sommerfeld, S., Bäcker, W., Aires-Barros, M.R.

“…Single-stage and multi-stage strategies have been evaluated and compared for the purification of human antibodies using liquid–liquid extraction in aqueous…”
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Impact of electronic-cigarette refill liquid on rat testis by El Golli, N., Rahali, D., Jrad-Lamine, A., Dallagi, Y., Jallouli, M., Bdiri, Y., Ba, N., Lebret, M., Rosa, J.P., El May, M., El Fazaa, S.

“…Electronic cigarettes (e-cigarettes) are becoming the fashionable alternative to decrease tobacco smoking, although their impact on health has not been fully…”
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Evora® chromium–cobalt dual mobility socket: Results at a minimum 10 years’ follow-up by Leclercq, S, Benoit, J.Y, de Rosa, J.P, Tallier, E, Leteurtre, C, Girardin, P.H

“…Summary Introduction The Evora chromium–cobalt alloy dual mobility socket claims to display a large articulation tribology different from that of stainless…”
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Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia by Chen, Y P, Djaffar, I, Pidard, D, Steiner, B, Cieutat, A M, Caen, J P, Rosa, J P

“…Integrins are membrane receptors which mediate cell-cell or cell-matrix adhesion. Integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) acts as a fibrinogen…”
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Processing and Assembly of the Integrin, Glycoprotein IIb-IIIa, in HEL Cells by Rosa, J P, McEver, R P

“…We examined the biosynthetic processing and assembly of the platelet glycoprotein (GP) IIb-IIIa complex in [35S]methionine-labeled HEL cells, a human cell line…”
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Facies analyses and volcanic setting of the giant Neves Corvo massive sulfide deposit, Iberian Pyrite Belt, Portugal by Rosa, Carlos J. P., McPhie, Jocelyn, Relvas, Jorge M. R. S., Pereira, Zélia, Oliveira, Tomás, Pacheco, Nelson

“…In the Iberian Pyrite Belt, volcanic rocks are relatively scarce, accounting for approximately only 25% of the geologic record, with the remaining 75%…”
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Aqueous two-phase systems: A viable platform in the manufacturing of biopharmaceuticals by Rosa, P.A.J., Ferreira, I.F., Azevedo, A.M., Aires-Barros, M.R.

“…The number of biotechnology-based pharmaceuticals in the late-stage pipeline has been increasing more than ever. As a result, there is an enhanced demand for…”
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Identification of a GATA-overlapping sequence within the enhancer of the murine GPIIb promoter that induces transcriptional deregulation in human K562 cells by Albanese, Patricia, Leboeuf, Marylène, Rosa, Jean-Philippe, Uzan, Georges

“…The human and the murine glycoprotein platelet IIb (GPIIb) promoters are megakaryocyte specific in human and murine cell systems, respectively. Here we show…”
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A second case of variant of Glanzmann's thrombasthenia due to substitution of platelet GPIIIa (integrin beta 3) Arg214 by Trp by Djaffar, I, Rosa, J P

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Expression of platelet membrane glycoproteins and alpha‐granule proteins by a human erythroleukemia cell line (HEL) by Tabilio, A., Rosa, J.P., Testa, U., Kieffer, N., Nurden, A.T., Del Canizo, M.C., Breton‐Gorius, J., Vainchenker, W.

“…We demonstrate that HEL, a human erythroleukemic cell line, has numerous megakaryocytic markers which were markedly enhanced following the addition of the…”
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Phosphorylation and dephosphorylation mechanisms in platelet function: a tightly regulated balance by Levy-Toledano, S, Gallet, C, Nadal, F, Bryckaert, M, Maclouf, J, Rosa, J P

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Fibrin clot retraction by human platelets correlates with alpha(IIb)beta(3) integrin-dependent protein tyrosine dephosphorylation by Osdoit, S, Rosa, J P

“…We have analyzed tyrosine phosphorylation associated with retraction of the fibrin clot by washed platelets in purified fibrinogen. Retraction was dependent on…”
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