Search Results - "ROOPENIAN, D. C"

Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis by Seymour, R E, Hasham, M G, Cox, G A, Shultz, L D, Hogenesch, H, Roopenian, D C, Sundberg, J P

“…Homologues of the SHARPIN (SHANK-associated RH domain-interacting protein) gene have been identified in the human, rat and mouse genomes. SHARPIN and its…”
Get full text

Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses by Blumberg, L J, Humphries, J E, Jones, S D, Pearce, L B, Holgate, R, Hearn, A, Cheung, J, Mahmood, A, Del Tito, B, Graydon, J S, Stolz, L E, Bitonti, A, Purohit, S, de Graaf, D, Kacena, K, Andersen, J T, Christianson, G J, Roopenian, D C, Hubbard, J J, Gandhi, A K, Lasseter, K, Pyzik, M, Blumberg, R S

“…The neonatal crystallizable fragment receptor (FcRn) functions as an intracellular protection receptor for immunoglobulin G (IgG). Recently, several clinical…”
Get full text

CD4+ T Cells and the Proinflammatory Cytokines Gamma Interferon and Interleukin-6 Contribute to Alveolar Bone Loss in Mice by BAKER, P. J, DIXON, M, EVANS, R. T, DUFOUR, L, JOHNSON, E, ROOPENIAN, D. C

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Genetic control of susceptibility to Porphyromonas gingivalis-induced alveolar bone loss in mice by BAKER, Pamela J, DIXON, Mark, ROOPENIAN, Derry C

“…Periodontal disease affects a large percentage of the human population. Resorption of the alveolar bone of the jaw is a pivotal sequela of periodontal disease,…”
Get full text

Quantitative Gene Expression Profiling Implicates Genes for Susceptibility and Resistance to Alveolar Bone Loss by HART, G. T, SHAFFER, D. J, AKILESH, S, BROWN, A. C, MORAN, L, ROOPENIAN, D. C, BAKER, P. J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease by Petkova, Stefka B., Akilesh, Shreeram, Sproule, Thomas J., Christianson, Gregory J., Al Khabbaz, Hana, Brown, Aaron C., Presta, Leonard G., Meng, Y. Gloria, Roopenian, Derry C.

“…The MHC class I-like Fc receptor FcRn plays an essential role in extending the half-life (t1/2) of IgG antibodies and IgG-Fc-based therapeutics in the…”
Get full text

Genetic Modification of Hearing in Tubby Mice: Evidence for the Existence of a Major Gene (moth1) Which Protects Tubby Mice from Hearing Loss by Ikeda, Akihiro, Yin Zheng, Qing, Rosenstiel, Philip, Maddatu, Terry, Zuberi, Aamir R., Roopenian, Derry C., North, Michael A., Naggert, Jürgen K., Johnson, Kenneth R., Nishina, Patsy M.

“…Quantitative trait locus (QTL) analysis of genetic crosses has proven to be a useful tool for identifying loci associated with specific phenotypes and for…”
Get full text

Quantitative Analysis of the Immune Response to Mouse Non-MHC Transplantation Antigens In Vivo: The H60 Histocompatibility Antigen Dominates Over All Others by Choi, Eun Young, Yoshimura, Yoshitaka, Christianson, Gregory J, Sproule, Thomas J, Malarkannan, Subramaniam, Shastri, Nilabh, Joyce, Sebastian, Roopenian, Derry C

“…Minor histocompatibility Ags (minor H Ags) are substantial impediments to MHC-matched solid tissue and bone marrow transplantation. From an antigenic…”
Get full text

Treatment of BXSB-Yaa Mice with IL-21R-Fc Fusion Protein Minimally Attenuates Systemic Lupus Erythematosus by BUBIER, J.A., BENNETT, S.M., SPROULE, T.J., LYONS, B.L., OLLAND, S., YOUNG, D.A., ROOPENIAN, D.C.

“…:  Interleukin‐21 (IL‐21) is a pleiotropic cytokine whose function is only now being unraveled. Abundant evidence indicates that activated CD4 T cells are the…”
Get full text

Pooling and PCR as a method to combat low frequency gene targeting in mouse embryonic stem cells by BROWN, A. C, LERNER, C. P, GRABER, J. H, SHAFFER, D. J, ROOPENIAN, D. C

“…The introduction of germ line modifications by gene targeting in mouse embryonic stem (ES) cells has proven a fundamental technology to relate genes to…”
Get full text

The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan by Chaudhury, Chaity, Mehnaz, Samina, Robinson, John M, Hayton, William L, Pearl, Dennis K, Roopenian, Derry C, Anderson, Clark L

“…The inverse relationship between serum albumin concentration and its half-life suggested to early workers that albumin would be protected from a catabolic fate…”
Get full text

Cardiac allograft tolerance : Failure to develop in interleukin-4-deficient mice correlates with unusual allosensitization patterns by SIRAK, J. H, OROSZ, C. G, ROOPENIAN, D. C, WAKELY, E, VANBUSKIRK, A. M

“…The development of long-term allograft survival and understanding the mechanism(s) by which it is induced are major goals of experimental transplantation…”
Get full text

Adhesion Molecule Deficiencies Increase Porphyromonas gingivalis-Induced Alveolar Bone Loss in Mice by BAKER, P. J, DUFOUR, L, DIXON, M, ROOPENIAN, D. C

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

The MHC Class I-Like IgG Receptor Controls Perinatal IgG Transport, IgG Homeostasis, and Fate of IgG-Fc-Coupled Drugs by Roopenian, Derry C, Christianson, Gregory J, Sproule, Thomas J, Brown, Aaron C, Akilesh, Shreeram, Jung, Nadja, Petkova, Stefka, Avanessian, Lia, Choi, Eun Young, Shaffer, Daniel J, Eden, Peter A, Anderson, Clark L

“…Abs of the IgG isotype are efficiently transported from mother to neonate and have an extended serum t(1/2) compared with Abs of other isotypes. Circumstantial…”
Get full text

The importance of MHC‐I and MHC‐II responses in vaccine efficacy against lethal herpes simplex virus type 1 challenge by GHIASI, H., ROOPENIAN, D. C., SLANINA, S., CAI, S., NESBURN, A. B., WECHSLER, S. L.

“…To investigate the importance of major histocompatability complex (MHC) class I‐ and MHC class II‐dependent immune responses in herpes simplex virus‐1 (HSV‐1)…”
Get full text

Efficient Chromosomal Mapping of a Methylcholanthrene- Induced Tumor Antigen by CTL Immunoselection by Akilesh, Shreeram, Dudley, Mark E, Eden, Peter A, Roopenian, Derry C

“…It has been difficult to genetically map the genes encoding tumor Ags because they arise as a consequence of somatic mutational events. CTL-mediated…”
Get full text

Mouse Strain Differences Determine Severity of Iron Accumulation in Hfe Knockout Model of Hereditary Hemochromatosis by Fleming, Robert E., Holden, Christopher C., Tomatsu, Shunji, Waheed, Abdul, Brunt, Elizabeth M., Britton, Robert S., Bacon, Bruce R., Roopenian, Derry C., Sly, William S.

“…Hereditary hemochromatosis (HH) is a common disorder of iron metabolism caused by mutation in HFE, a gene encoding an MHC class I-like protein. Clinical…”
Get full text

Immunodominance of H60 Is Caused by an Abnormally High Precursor T Cell Pool Directed against Its Unique Minor Histocompatibility Antigen Peptide by Choi, Eun Young, Christianson, Gregory J, Yoshimura, Yoshitaka, Sproule, Thomas J, Jung, Nadja, Joyce, Sebastian, Roopenian, Derry C

“…The H60 minor histocompatibility (H) antigen peptide is derived from a glycoprotein that serves as a ligand for the stimulatory NKG2D receptor. We show that…”
Get full text

Another View of T Cell Antigen Recognition: Cooperative Engagement of Glycolipid Antigens by Va14Ja18 Natural TCR by Stanic, Aleksandar K, Shashidharamurthy, R, Bezbradica, Jelena S, Matsuki, Naoto, Yoshimura, Yoshitaka, Miyake, Sachiko, Choi, Eun Young, Schell, Todd D, Van Kaer, Luc, Tevethia, Satvir S, Roopenian, Derry C, Yamamura, Takashi, Joyce, Sebastian

“…Abstract Va14Ja18 natural T (iNKT) cells rapidly elicit a robust effector response to different glycolipid Ags, with distinct functional outcomes. Biochemical…”
Get full text

MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice by Serreze, D. V., Gallichan, W. S., Snider, D. P., Croitoru, K., Rosenthal, K. L., Leiter, E. H., Christianson, G. J., Dudley, M. E., Roopenian, D. C.

“…MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice. D V Serreze , W S Gallichan ,…”
Get full text