Search Results - "ROODMAN, G. D"

Pathogenesis of myeloma bone disease by Roodman, G D

“…Bone disease in multiple myeloma (MM) is characterized by lytic bone lesions, which can cause severe bone pain, pathologic fractures and hypercalcemia…”
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Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth by Delgado-Calle, J, Anderson, J, Cregor, M D, Condon, K W, Kuhstoss, S A, Plotkin, L I, Bellido, T, Roodman, G D

“…Multiple myeloma (MM) causes lytic bone lesions due to increased bone resorption and concomitant marked suppression of bone formation. Sclerostin (Scl), an…”
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Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo by Teramachi, J, Silbermann, R, Yang, P, Zhao, W, Mohammad, K S, Guo, J, Anderson, J L, Zhou, D, Feng, R, Myint, K-Z, Maertz, N, Beumer, J H, Eiseman, J L, Windle, J J, Xie, X-Q, Roodman, G D, Kurihara, N

“…We reported that p62 (sequestosome 1) serves as a signaling hub in bone marrow stromal cells (BMSCs) for the formation of signaling complexes, including NFκB,…”
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Involvement of Hepcidin in the Anemia of Multiple Myeloma by SHARMA, Sanjai, NEMETH, Elizabeta, CHEN, Yi-Hsiang, GOODNOUGH, Julia, HUSTON, Alissa, ROODMAN, G. D, GANZ, Tomas, LICHTENSTEIN, Alan

“…Purpose: Hepcidin is a liver-produced peptide implicated in the anemia of inflammation. Because interleukin (IL)-6 is a potent inducer of hepcidin expression…”
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Biology of Osteoclast Activation in Cancer by ROODMAN, G. David

“…Bone is a frequent site of cancer metastasis. Bone metastases can result in bone destruction or new bone formation. Bone destruction is mediated by factors…”
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Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma by CHOI, S. J, CRUZ, J. C, CRAIG, F, HOYEON CHUNG, DEVLIN, R. D, ROODMAN, G. D, ALSINA, M

“…This study was designed to determine if macrophage inhibitory protein-1 alpha (MIP-1 alpha), a recently described osteoclast (OCL) stimulatory factor,(1) was…”
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A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates by PARFITT, A. M, MUNDY, G. R, ROODMAN, G. D, HUGHES, D. E, BOYCE, B. F

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The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG) by Kyriakou, Charalampia, Molloy, Sean, Vrionis, Frank, Alberico, Ronald, Bastian, Leonard, Zonder, Jeffrey A., Giralt, Sergio, Raje, Noopur, Kyle, Robert A., Roodman, David G. D., Dimopoulos, Meletios A., Rajkumar, S. Vincent, Durie, Brian B. G., Terpos, Evangelos

“…Multiple myeloma (MM) represents approximately 15% of haematological malignancies and most of the patients present with bone involvement. Focal or diffuse…”
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Mechanisms of bone lesions in multiple myeloma and lymphoma by Roodman, G. David

“…BACKGROUND Bone lesions and hypercalcemia occur rarely in patients with hematologic malignancies, except those patients with multiple myeloma and adult T‐cell…”
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Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery by Kovacs, J R, Li, C, Yang, Q, Li, G, Garcia, I G, Ju, S, Roodman, D G, Windle, J J, Zhang, X, Lu, B

“…Autophagy is implicated in regulating cell death in activated T cells, but the underlying mechanism is unclear. Here, we show that inhibition of autophagy via…”
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Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo by Hughes, David E., Wright, Kenneth R., Uy, Harry L., Sasaki, Akira, Yoneda, Toshiyuki, Roodman, David G., Mundy, Gregory R., Boyce, Brendan F.

“…Bisphosphonates inhibit bone resorption and are therapeutically effective in diseases of increased bone turnover, such as Paget's disease and hypercalcemia of…”
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Interleukin 6 : a potential autocrine/paracrine factor in Paget's disease of bone by ROODMAN, G. D, KURIHARA, N, OHSAKI, Y, HOSKING, D, DEMULDER, A, SMITH, J. F, SINGER, F. R

“…Pagetic osteoclasts are greatly increased in number and size and have increased numbers of nuclei per cell compared to normal osteoclasts. The mechanisms…”
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Genetic Linkage of Paget Disease of the Bone to Chromosome 18q by Cody, J.D., Singer, F.R., Roodman, G.D., Otterund, B., Lewis, T.B., Leppert, M., Leach, R.J.

“…Paget disease is a common bone disease characterized by abnormal osteoclasts that are large, multinucleated, and overactive and that contain paramyxovirus-like…”
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IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release by Kurihara, N, Bertolini, D, Suda, T, Akiyama, Y, Roodman, GD

“…IL-6 enhances the differentiation of pluripotent hematopoietic stem cells but predominantly affects the differentiation of hematopoietic cells in the…”
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Perspectives: Interleukin‐6: An osteotropic factor? by Roodman, G.D.

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Galectin-1 suppression delineates a new strategy to inhibit myeloma-induced angiogenesis and tumoral growth in vivo by Storti, P, Marchica, V, Airoldi, I, Donofrio, G, Fiorini, E, Ferri, V, Guasco, D, Todoerti, K, Silbermann, R, Anderson, J L, Zhao, W, Agnelli, L, Bolzoni, M, Martella, E, Mancini, C, Campanini, N, Noonan, D M, Petronini, P G, Neri, A, Aversa, F, Roodman, G D, Giuliani, N

“…Galectin-1 (Gal-1) is involved in tumoral angiogenesis, hypoxia and metastases. Actually the Gal-1 expression profile in multiple myeloma (MM) patients and its…”
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Identification of committed mononuclear precursors for osteoclast-like cells formed in long term human marrow cultures by Kurihara, N, Chenu, C, Miller, M, Civin, C, Roodman, G D

“…Nonadherent marrow mononuclear cells enriched for hematopoietic progenitor cells were cultured in semisolid medium with recombinant human…”
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Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone by Ohsaki, Y, Takahashi, S, Scarcez, T, Demulder, A, Nishihara, T, Williams, R, Roodman, G D

“…Interleukin-6 (IL-6) is a multifunctional cytokine whose role in osteoclastic bone resorption has not been clearly defined. Therefore, we have used giant…”
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Interleukin-6 : A potential mediator of the massive osteolysis in patients with Gorham-Stout disease by DEVLIN, R. D, BONE, H. G, ROODMAN, G. D

“…Gorham-Stout disease (GSD) or massive osteolysis, is an extremely rare osteolytic condition that involves extensive locally aggressive resorption of bone. The…”
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Treatment strategies for bone disease by Roodman, G D

“…Multiple myeloma is characterized by extensive bone destruction with little or no new bone formation. A multiplicity of factors including receptor activator…”
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