Search Results - "RONZAUD, Caroline"

Ubiquitylation and control of renal Na+ balance and blood pressure by Ronzaud, Caroline, Staub, Olivier

“…Ubiquitylation is crucial for regulating numerous cellular functions. In the kidney, ubiquitylation regulates the epithelial Na(+) channel ENaC. The importance…”
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Aldosterone paradox: differential regulation of ion transport in distal nephron by Arroyo, Juan Pablo, Ronzaud, Caroline, Lagnaz, Dagmara, Staub, Olivier, Gamba, Gerardo

“…The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K(+) secretion remain poorly understood. The…”
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Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action by Roy, Ankita, Al-Qusairi, Lama, Donnelly, Bridget F, Ronzaud, Caroline, Marciszyn, Allison L, Gong, Fan, Chang, Y P Christy, Butterworth, Michael B, Pastor-Soler, Núria M, Hallows, Kenneth R, Staub, Olivier, Subramanya, Arohan R

“…The thiazide-sensitive NaCl cotransporter (NCC) is important for renal salt handling and blood-pressure homeostasis. The canonical NCC-activating pathway…”
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Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor by RONZAUD, Caroline, LOFFING, Johannes, BLEICH, Markus, GRETZ, Norbert, GRONE, Hermann-Josef, SCHUTZ, Günther, BERGER, Stefan

“…Germline inactivation of the mineralocorticoid receptor (MR) gene in mice results in postnatal lethality as a result of massive loss of sodium and water. The…”
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Inducible renal principal cell-specific mineralocorticoid receptor gene inactivation in mice by Ronzaud, Caroline, Loffing, Johannes, Gretz, Norbert, Schütz, Günther, Berger, Stefan

“…To investigate the role of the mineralocorticoid receptor (MR) in renal ENaC-mediated sodium reabsorption, we have previously used the Cre-loxP system to…”
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Nedd4-2 Modulates Renal Na+-Cl― Cotransporter via the Aldosterone-SGK1-Nedd4-2 Pathway by PABLO ARROYO, Juan, LAGNAZ, Dagmara, STOKES, John B, HOOVER, Robert S, GAMBA, Gerardo, STAUB, Olivier, RONZAUD, Caroline, VAZQUEZ, Norma, KO, Benjamin S, MODDES, Lauren, RUFFIEUX-DAIDIE, Dorothée, HAUSEL, Pierrette, KOESTERS, Robert, YANG, Baoli

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The serine‐threonine kinase PIM3 is an aldosterone‐regulated protein in the distal nephron by Spirli, Alessia, Cheval, Lydie, Debonneville, Anne, Penton, David, Ronzaud, Caroline, Maillard, Marc, Doucet, Alain, Loffing, Johannes, Staub, Olivier

“…The mineralocorticoid hormone aldosterone plays a crucial role in the control of Na+ and K+ balance, blood volume, and arterial blood pressure, by acting in…”
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Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension by Ronzaud, Caroline, Loffing-Cueni, Dominique, Hausel, Pierrette, Debonneville, Anne, Malsure, Sumedha Ram, Fowler-Jaeger, Nicole, Boase, Natasha A, Perrier, Romain, Maillard, Marc, Yang, Baoli, Stokes, John B, Koesters, Robert, Kumar, Sharad, Hummler, Edith, Loffing, Johannes, Staub, Olivier

“…The E3 ubiquitin ligase NEDD4-2 (encoded by the Nedd4L gene) regulates the amiloride-sensitive epithelial Na+ channel (ENaC/SCNN1) to mediate Na+ homeostasis…”
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Renal Salt and Water Homeostasis: a New Regulatory Pathway Involving the Ser/Thr Kinase PIM‐3 by Spirli, Alessia, Ronzaud, Caroline, Debonneville, Anne, Staub, Olivier

“…Abstract only Since many years now, scientists believe that a great credit for the blood pressure regulation goes to the kidneys, as their inability in…”
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Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway by Arroyo, Juan Pablo, Lagnaz, Dagmara, Ronzaud, Caroline, Vázquez, Norma, Ko, Benjamin S, Moddes, Lauren, Ruffieux-Daidié, Dorothée, Hausel, Pierrette, Koesters, Robert, Yang, Baoli, Stokes, John B, Hoover, Robert S, Gamba, Gerardo, Staub, Olivier

“…Regulation of renal Na(+) transport is essential for controlling blood pressure, as well as Na(+) and K(+) homeostasis. Aldosterone stimulates Na(+)…”
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Sodium and Potassium Balance Depends on αENaC Expression in Connecting Tubule by MONSTER CHRISTENSEN, Birgitte, PERRIER, Romain, HUMMLER, Edith, QING WANG, MERCIER ZUBER, Annie, MAILLARD, Marc, MORDASINI, David, MALSURE, Sumedha, RONZAUD, Caroline, STEHLE, Jean-Christophe, ROSSIER, Bernard C

“…Mutations in α, β, or γ subunits of the epithelial sodium channel (ENaC) can downregulate ENaC activity and cause a severe salt-losing syndrome with…”
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PPARγ agonist-induced fluid retention depends on αENaC expression in connecting tubules by Fu, Yiling, Gerasimova, Maria, Batz, Falk, Kuczkowski, Alexander, Alam, Yasaman, Sanders, Paul W, Ronzaud, Caroline, Hummler, Edith, Vallon, Volker

“…Thiazolidinediones (TZDs, like rosiglitazone (RGZ)) are peroxisome proliferator-activated receptor γ (PPARγ) agonists used to treat type 2 diabetes. Clinical…”
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Role of the renal mineralocorticoid receptor for potassium homeostasis by Roesinger, Marian, Loffing‐Cueni, Dominique, Ronzaud, Caroline, Canonica, Jérémie, Debonneville, Anne, Hummler, Edith, Staub, Olivier, Loffing, Johannes

“…Abstract only Aldosterone enhances renal K + excretion via ROMK channels and stimulates apical epithelial Na + channels (ENaC) to provide the electrochemical…”
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Loss of renal Nedd4‐2 in adult mice leads to PHAII compensated by ENaC down‐regulation and ROMK up‐regulation by Staub, Olivier, Ronzaud, Caroline, Loffing, Dominique, Debonneville, Anne, Yang, Baoli, Stokes, John, Koesters, Robert, Hummler, Edith, Loffing, Johannes

“…Abstract only Constitutive Nedd4‐2 knockout (KO) mice show Na + retention and salt‐sensitive hypertension. To determine the role of renal Nedd4‐2 in adult…”
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WNK3 Prevents the Nedd4‐2 Inhibition of the Renal Na‐Cl Cotransporter (NCC) by Arroyo, Juan Pablo, Rojas-Vega, Lorena, Lagnaz, Dagmara, Castañeda-Bueno, María, Ronzaud, Caroline, Vázquez, Norma, Staub, Olivier, Gamba, Gerardo

“…Abstract only NCC and ENaC are inhibited by the E3 ubiquitin ligase Nedd4‐2 (JASN, 2011) and elimination of two canonical SGK1 phosphorylation sites on Nedd4‐2…”
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