Search Results - "RONG SHENG YANG"

Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan by Cheung‐Lee, Wai Ling, Kolev, Joshua N., McIntosh, John A., Gil, Agnieszka A., Pan, Weilan, Xiao, Li, Velásquez, Juan E., Gangam, Rekha, Winston, Matthew S., Li, Shasha, Abe, Kotoe, Alwedi, Embarek, Dance, Zachary E. X., Fan, Haiyang, Hiraga, Kaori, Kim, Jungchul, Kosjek, Birgit, Le, Diane N., Marzijarani, Nastaran Salehi, Mattern, Keith, McMullen, Jonathan P., Narsimhan, Karthik, Vikram, Ajit, Wang, Wei, Yan, Jia‐Xuan, Yang, Rong‐Sheng, Zhang, Victoria, Zhong, Wendy, DiRocco, Daniel A., Morris, William J., Murphy, Grant S., Maloney, Kevin M.

“…Biocatalytic oxidations are an emerging technology for selective C−H bond activation. While promising for a range of selective oxidations, practical use of…”
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Preparation, mechanical and thermal properties of functionalized graphene/polyimide nanocomposites by Zhang, Li-Bin, Wang, Jin-Qing, Wang, Hong-Gang, Xu, Ye, Wang, Zhao-Feng, Li, Zhang-Peng, Mi, Yong-Juan, Yang, Sheng-Rong

“…Graphene oxide sheets with isocyanate functional groups (GONCO) were firstly synthesized and functionalized graphene/polyimide (FGS/PI) nanocomposites were…”
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Rapid Characterization of Insulin Modifications and Sequence Variations by Proteinase K Digestion and UHPLC-ESI-MS by Yang, Rong-Sheng, Tang, Weijuan, Sheng, Huaming, Meng, Fanyu

“…Discovery of novel insulin analogs as therapeutics has remained an active area of research. Compared with native human insulin, insulin analog molecules…”
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Unexpected Propargylic Retro-Brook Rearrangements in Alkynes by Wang, Xiao, Gao, Qi, Buevich, Alexei V, Yasuda, Nobuyoshi, Zhang, Yonglian, Yang, Rong-Sheng, Zhang, Li-Kang, Martin, Gary E, Williamson, R. Thomas

“…Retro-Brook rearrangements refer to the intramolecular migration of a silyl group from oxygen to carbon. In this study, we report a novel propargylic…”
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Mechanistic Study of the Gas-Phase In-Source Hofmann Elimination of Doubly Quaternized Cinchona-Alkaloid Based Phase-Transfer Catalysts by (+)-Electrospray Ionization/Tandem Mass Spectrometry by Yang, Rong-Sheng, Sheng, Huaming, Lexa, Katrina W., Sherer, Edward C., Zhang, Li-Kang, Xiang, Bangping, Helmy, Roy, Mao, Bing

“…An unusual in-source fragmentation pattern observed for 14 doubly quaternized cinchona alkaloid-based phase-transfer catalysts (PTC) was studied using (+)-ESI…”
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Unusual (+/–)‐electrospray ionization induced fragmentation: Structural elucidation of an in‐process synthetic intermediate of doravirine (MK‐1439) using liquid chromatography/high‐resolution tandem mass spectrometry and two‐dimensional nuclear magnetic resonance by Sheng, Huaming, Lexa, Katrina W., Zhang, Li‐Kang, Yang, Rong‐Sheng, Wright, Timothy J., Sherry, Benjamin D., Helmy, Roy, Martin, Gary E.

“…Rationale During the development of a novel synthetic route to doravirine (1), a human immunodeficiency type 1 virus (HIV‐1) nonnucleoside reverse…”
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A facile preparation and electrochemical properties of nickel based compound-graphene sheet composites for supercapacitors by Zhang, Li-Bin, Yang, Sheng-Rong, Wang, Jin-Qing, Xu, Ye, Kong, Xiang-Zheng

“…Composites of a nickel based compound incorporated with graphene sheets （NiBC-GS） are prepared by a simple flocculation, using hydrazine hydrate as flocculant…”
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Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization by Prongay, Andrew J, Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers, Joseph, Weber, Patricia C, Beyer, Brian M, Ingram, Richard, Hong, Zhi, Prosise, Winifred W, Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G, Saksena, Anil K, Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George, Madison, Vincent

“…The structures of both the native holo-HCV NS3/4A protease domain and the protease domain with a serine 139 to alanine (S139A) mutation were solved to high…”
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Preparation and Tribological Studies of Stearic Acid Self-Assembled Monolayers on Polymer-Coated Silicon Surface by Ren, Si-Li, Yang, Sheng-Rong, Wang, Jin-Qing, Liu, Wei-Min, Zhao, Ya-Pu

“…We present a good alternative method to improve the tribological properties of polymer films by chemisorbing a long-chain monolayer on the functional polymer…”
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Mechanical and tribological behaviors of PA66/PVDF blends filled with calcium sulphate whiskers by Wang, Hong-Gang, Mu, Bo, Ren, Jun-Fang, Jian, Ling-Qi, Zhang, Jun-Yan, Yang, Sheng-Rong

“…The mechanical and tribological performance of the PA66/PVDF blends filled with various amount of calcium sulphate whiskers (CSW) was investigated. The…”
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Advancing Structure Characterization of PS-80 by Charge-Reduced Mass Spectrometry and Software-Assisted Composition Analysis by Yang, Rong-Sheng, Bush, David R, DeGraan-Weber, Nick, Barbacci, Damon, Zhang, Li-Kang, Letarte, Simon, Richardson, Douglas

“…The commercially available Polysorbate 80 (PS-80) is a highly heterogeneous product. It is a complex and structurally diverse mixture consisting of polymeric…”
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Extensive Characterization of Polysorbate 80 Oxidative Degradation Under Stainless Steel Conditions by Zheng, Xiwei, Sutton, Adam T, Yang, Rong-Sheng, Miller, Danielle V, Pagels, Becca, Rustandi, Richard R, Welch, Jonathan, Payne, Anne, Haverick, Mark

“…Polysorbate-80 (PS-80) is a common surfactant used in biologics formulations. However, the tendency of oxidation to PS-80 when exposed to stainless steel…”
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Low-molecular-weight impurity in Poloxamer 188 responsible for atypical cell culture performance for mAb production by Bandyopadhyay, Arpan, Kosanam, Hari, Yang, Rong-Sheng, Gupta, Balrina, Naralakattu, Naja, Pakhale, Shital, Kress, Jared, Richardson, Douglas, Ly, Jeffrey

“…During a recent manufacturing campaign for a monoclonal antibody using a fed-batch process, poor cell culture performance was observed across two manufacturing…”
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Mechanical and tribological behaviors of polyamide 66/ultra high molecular weight polyethylene blends by Wang, Hong-Gang, Jian, Ling-Qi, Pan, Bing-Li, Zhang, Jun-Yan, Yang, Sheng-Rong, Wang, Hong-Gang

“…The blends of polyamide (PA) and ultra high molecular weight polyethylene (UHMWPE) were prepared by a Brabender DSE25 co‐twin screw extruder, and maleic…”
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Mechanistic insight into the oxazoline decomposition of DFC-M, a synthetic intermediate of florfenicol by Yang, Rong-Sheng, Wang, Xiao, Tang, Weijuan, Celly, Chander, Sheng, Huaming

“…•DFC-M is a key oxazoline-containing intermediate in commercial process for the synthesis of Florfenicol.•The unique acidic solution degradation mechanism of…”
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Development of a highly efficient decontamination approach for ceftolozane in the pharmaceutical manufacturing environment by Yang, Rong-Sheng, Zhang, Li-Kang, Helmy, Roy, Andreani, Teresa, Liu, Zhijian, Sheng, Huaming

“…•A highly efficient decontamination method was developed for ceftolozane as well as other cephalosporin antibiotics.•UHPLC-HRMS/MS method is sensitive and…”
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Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors by Fischmann, Thierry O, Smith, Catherine K, Mayhood, Todd W, Myers, Joseph E, Reichert, Paul, Mannarino, Anthony, Carr, Donna, Zhu, Hugh, Wong, Jesse, Yang, Rong-Sheng, Le, Hung V, Madison, Vincent S

“…MEK1 is a member of the MAPK signal transduction pathway that responds to growth factors and cytokines. We have determined that the kinase domain spans…”
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Applications of TiCl3 as a Diagnostic Reagent for the Detection of Nitro- and N‑Oxide-Containing Compounds as Potentially Mutagenic Impurities Using Ultrahigh-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry by Yang, Rong-Sheng, Beard, Adam, Sheng, Huaming, Zhang, Li-Kang, Helmy, Roy

“…The ICH has strict guidelines for limiting the presence of potentially mutagenic impurities (PMIs) in marketed drugs. Therefore, it is important to fully…”
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Friction and Wear Behavior of Polyamide 66/Poly(vinylidene fluoride) Blends by Wang, Hong-gang, Ren, Jun-fang, Jian, Ling-qi, Pan, Bing-li, Zhang, Jun-yan, Yang, Sheng-rong

“…The tribological performance of PA66 and PVDF blends was investigated by a block-on ring sliding friction and wear tester. The appropriate amount of PVDF can…”
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Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034 by Madison, Vincent, Prongay, Andrew J., Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers Jr, Joseph, Weber, Patricia C., Beyer, Brian M., Ingram, Richard, Hong, Zhi, Prosise, Winifred W., Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L., Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G., Saksena, Anil K., Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George

“…The structures of both native and S139A holo‐HCV NS3/4A protease domain were solved to high resolution. Subsequently, structures were determined for a series…”
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