Search Results - "RONCARATI, Davide"
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Regulation of heat-shock genes in bacteria: from signal sensing to gene expression output
Published in FEMS microbiology reviews (01-07-2017)“…Abstract The heat-shock response is a mechanism of cellular protection against sudden adverse environmental growth conditions and results in the prompt…”
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The Interplay between Two Transcriptional Repressors and Chaperones Orchestrates Helicobacter pylori Heat-Shock Response
Published in International journal of molecular sciences (07-06-2018)“…The ability to gauge the surroundings and modulate gene expression accordingly is a crucial feature for the survival bacterial pathogens. In this respect, the…”
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3
Insights into the Orchestration of Gene Transcription Regulators in Helicobacter pylori
Published in International journal of molecular sciences (08-11-2022)“…Bacterial pathogens employ a general strategy to overcome host defenses by coordinating the virulence gene expression using dedicated regulatory systems that…”
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Definition of the Binding Architecture to a Target Promoter of HP1043, the Essential Master Regulator of Helicobacter pylori
Published in International journal of molecular sciences (01-08-2021)“…HP1043 is an essential orphan response regulator of Helicobacter pylori orchestrating multiple crucial cellular processes. Classified as a member of the…”
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Targeting of Regulators as a Promising Approach in the Search for Novel Antimicrobial Agents
Published in Microorganisms (Basel) (15-01-2022)“…Since the discovery of penicillin in the first half of the last century, antibiotics have become the pillars of modern medicine for fighting bacterial…”
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SrnR from Streptomyces griseus is a nickel-binding transcriptional activator
Published in Journal of biological inorganic chemistry (01-03-2020)“…Nickel ions are crucial components for the catalysis of biological reactions in prokaryotic organisms. As an uncontrolled nickel trafficking is toxic for…”
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7
Levofloxacin and Ciprofloxacin Co-Crystals with Flavonoids: Solid-State Investigation for a Multitarget Strategy against Helicobacter pylori
Published in Pharmaceutics (30-01-2024)“…In this paper, we address the problem of antimicrobial resistance in the case of with a crystal engineering approach. Two antibiotics of the fluoroquinolone…”
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Comprehensive mapping of the Helicobacter pylori NikR regulon provides new insights in bacterial nickel responses
Published in Scientific reports (10-04-2017)“…Nickel homeostasis is important for pathogenic and ureolytic bacteria, which use this metal ion as enzymatic cofactor. For example, in the human pathogen…”
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In depth analysis of the Helicobacter pylori cag pathogenicity island transcriptional responses
Published in PloS one (03-06-2014)“…The severity of symptoms elicited by the widespread human pathogen Helicobacter pylori is strongly influenced by the genetic diversity of the infecting strain…”
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Paradigm Shift in Gastric Cancer Prevention: Harnessing the Potential of Aristolochia olivieri Extract
Published in International journal of molecular sciences (01-11-2023)“…Gastric cancer, particularly adenocarcinoma, is a significant global health concern. Environmental risk factors, such as Helicobacter pylori infection and…”
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11
Metal-responsive promoter DNA compaction by the ferric uptake regulator
Published in Nature communications (25-08-2016)“…Short-range DNA looping has been proposed to affect promoter activity in many bacterial species and operator configurations, but only few examples have been…”
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Feeling the Heat: The Campylobacter jejuni HrcA Transcriptional Repressor Is an Intrinsic Protein Thermosensor
Published in Biomolecules (Basel, Switzerland) (27-09-2021)“…The heat-shock response, a universal protective mechanism consisting of a transcriptional reprogramming of the cellular transcriptome, results in the…”
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13
One ligand, two regulators and three binding sites: How KDPG controls primary carbon metabolism in Pseudomonas
Published in PLoS genetics (28-06-2017)“…Effective regulation of primary carbon metabolism is critically important for bacteria to successfully adapt to different environments. We have identified an…”
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14
Cooperative Regulation of Campylobacter jejuni Heat-Shock Genes by HspR and HrcA
Published in Microorganisms (Basel) (30-07-2020)“…The heat-shock response is defined by the transient gene-expression program that leads to the rapid accumulation of heat-shock proteins. This evolutionary…”
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15
Targeting the Essential Transcription Factor HP1043 of Helicobacter pylori : A Drug Repositioning Study
Published in Frontiers in molecular biosciences (11-05-2022)“…Antibiotic-resistant bacterial pathogens are a very challenging problem nowadays. is one of the most widespread and successful human pathogens since it…”
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The Helicobacter pylori HspR-Modulator CbpA Is a Multifunctional Heat-Shock Protein
Published in Microorganisms (Basel) (13-02-2020)“…The medically important human pathogen relies on a collection of highly conserved heat-shock and chaperone proteins to preserve the integrity of cellular…”
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The Helicobacter pylori Heat-Shock Repressor HspR: Definition of Its Direct Regulon and Characterization of the Cooperative DNA-Binding Mechanism on Its Own Promoter
Published in Frontiers in microbiology (14-08-2018)“…The ability of pathogens to perceive environmental conditions and modulate gene expression accordingly is a crucial feature for bacterial survival. In this…”
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18
Helicobacter pylori Stress-Response: Definition of the HrcA Regulon
Published in Microorganisms (Basel) (11-10-2019)“…Bacteria respond to different environmental stresses by reprogramming the transcription of specific genes whose proper expression is critical for their…”
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In Vivo Dissection of the Helicobacter pylori Fur Regulatory Circuit by Genome-Wide Location Analysis
Published in Journal of Bacteriology (01-07-2006)“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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CbpA Acts as a Modulator of HspR Repressor DNA Binding Activity in Helicobacter pylori
Published in Journal of Bacteriology (01-10-2011)“…The ability of pathogens to cope with disparate environmental stresses is a crucial feature for bacterial survival and for the establishment of a successful…”
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