Search Results - "RON, David"

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation by Walter, Peter, Ron, David

“…The vast majority of proteins that a cell secretes or displays on its surface first enter the endoplasmic reticulum (ER), where they fold and assemble. Only…”
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Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress by Tabas, Ira, Ron, David

“…The ability to respond to perturbations in endoplasmic reticulum (ER) function is a fundamentally important property of all cells, but ER stress can also lead…”
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Translational control in the endoplasmic reticulum stress response by Ron, David

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Early Events in the Endoplasmic Reticulum Unfolded Protein Response by Preissler, Steffen, Ron, David

“…The physiological consequences of the unfolded protein response (UPR) are mediated by changes in gene expression. Underlying them are rapid processes involving…”
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Signal integration in the endoplasmic reticulum unfolded protein response by Ron, David, Walter, Peter

“…The endoplasmic reticulum (ER) responds to the accumulation of unfolded proteins in its lumen (ER stress) by activating intracellular signal transduction…”
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Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains by Volmer, Romain, van der Ploeg, Kattria, Ron, David

“…Endoplasmic reticulum (ER) stress sensors use a related luminal domain to monitor the unfolded protein load and convey the signal to downstream effectors,…”
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mitochondrial UPR - protecting organelle protein homeostasis by Haynes, Cole M, Ron, David

“…Mitochondria are required for numerous essential metabolic processes including the regulation of apoptosis; therefore, proper maintenance of the mitochondrial…”
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Endoplasmic Reticulum Stress Signaling in Disease by Marciniak, Stefan J, Ron, David

“…Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom; and Skirball Institute of Biomolecular Medicine, New York…”
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Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis by Tsaytler, Pavel, Harding, Heather P., Ron, David, Bertolotti, Anne

“…Many biological processes are regulated through the selective dephosphorylation of proteins. Protein serine-threonine phosphatases are assembled from catalytic…”
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MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP by Yan, Yahui, Rato, Claudia, Rohland, Lukas, Preissler, Steffen, Ron, David

“…Despite its known role as a secreted neuroprotectant, much of the mesencephalic astrocyte-derived neurotrophic factor (MANF) is retained in the endoplasmic…”
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Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse by Ron, David

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Mutations in a translation initiation factor identify the target of a memory-enhancing compound by Sekine, Yusuke, Zyryanova, Alisa, Crespillo-Casado, Ana, Fischer, Peter M., Harding, Heather P., Ron, David

“…The integrated stress response (ISR) modulates messenger RNA translation to regulate the mammalian unfolded protein response (UPR), immunity, and memory…”
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A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response by Amin-Wetzel, Niko, Saunders, Reuben A., Kamphuis, Maarten J., Rato, Claudia, Preissler, Steffen, Harding, Heather P., Ron, David

“…When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein response (UPR) increases ER-protein-folding capacity to restore…”
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GDF15 mediates the effects of metformin on body weight and energy balance by Coll, Anthony P., Chen, Michael, Taskar, Pranali, Rimmington, Debra, Patel, Satish, Tadross, John A., Cimino, Irene, Yang, Ming, Welsh, Paul, Virtue, Samuel, Goldspink, Deborah A., Miedzybrodzka, Emily L., Konopka, Adam R., Esponda, Raul Ruiz, Huang, Jeffrey T.-J., Tung, Y. C. Loraine, Rodriguez-Cuenca, Sergio, Tomaz, Rute A., Harding, Heather P., Melvin, Audrey, Yeo, Giles S. H., Preiss, David, Vidal-Puig, Antonio, Vallier, Ludovic, Nair, K. Sreekumaran, Wareham, Nicholas J., Ron, David, Gribble, Fiona M., Reimann, Frank, Sattar, Naveed, Savage, David B., Allan, Bernard B., O’Rahilly, Stephen

“…Metformin, the world’s most prescribed anti-diabetic drug, is also effective in preventing type 2 diabetes in people at high risk 1 , 2 . More than 60% of this…”
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Higher-order phosphatase–substrate contacts terminate the integrated stress response by Yan, Yahui, Harding, Heather P., Ron, David

“…Many regulatory PPP1R subunits join few catalytic PP1c subunits to mediate phosphoserine and phosphothreonine dephosphorylation in metazoans. Regulatory…”
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The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans by Haynes, Cole M., Yang, Yun, Blais, Steven P., Neubert, Thomas A., Ron, David

“…Genetic analyses previously implicated the matrix-localized protease ClpP in signaling the stress of protein misfolding in the mitochondrial matrix to activate…”
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ClpP Mediates Activation of a Mitochondrial Unfolded Protein Response in C. elegans by Haynes, Cole M., Petrova, Kseniya, Benedetti, Cristina, Yang, Yun, Ron, David

“…The cellular response to unfolded and misfolded proteins in the mitochondrial matrix is poorly understood. Here, we report on a genome-wide RNAi-based screen…”
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Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B by Zyryanova, Alisa F, Weis, Félix, Faille, Alexandre, Alard, Akeel Abo, Crespillo-Casado, Ana, Sekine, Yusuke, Harding, Heather P, Allen, Felicity, Parts, Leopold, Fromont, Christophe, Fischer, Peter M, Warren, Alan J, Ron, David

“…The integrated stress response (ISR) is a conserved translational and transcriptional program affecting metabolism, memory, and immunity. The ISR is mediated…”
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Oxidative Protein Folding by an Endoplasmic Reticulum-Localized Peroxiredoxin by Zito, Ester, Melo, Eduardo Pinho, Yang, Yun, Wahlander, Åsa, Neubert, Thomas A., Ron, David

“…Endoplasmic reticulum (ER) oxidation 1 (ERO1) transfers disulfides to protein disulfide isomerase (PDI) and is essential for oxidative protein folding in…”
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The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells by Harding, Heather P, Ordonez, Adriana, Allen, Felicity, Parts, Leopold, Inglis, Alison J, Williams, Roger L, Ron, David

“…The eukaryotic translation initiation factor 2α (eIF2α) kinase GCN2 is activated by amino acid starvation to elicit a rectifying physiological program known as…”
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