Search Results - "ROMANO, Raffaella"
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Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory
Published in Proceedings of the National Academy of Sciences - PNAS (18-12-2007)“…Subcortical dopamine D2 receptor (DRD2) signaling is implicated in cognitive processes and brain disorders, but the effect of DRD2 variants remains ambiguous…”
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Low plasma PD-L1 levels, early tumor onset and absence of peritoneal carcinomatosis improve prognosis of women with advanced high-grade serous ovarian cancer
Published in BMC cancer (13-05-2023)“…The most common subtype of ovarian cancer (OC) showing immunogenic potential is represented by the high-grade serous ovarian cancer (HGSOC), which is…”
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Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia
Published in Brain (London, England : 1878) (01-02-2009)“…Dopamine D2 receptor signalling is strongly implicated in the aetiology of schizophrenia. We have recently characterized the function of three DRD2 SNPs:…”
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Can circulating PD-1, PD-L1, BTN3A1, pan-BTN3As, BTN2A1 and BTLA levels enhance prognostic power of CA125 in patients with advanced high-grade serous ovarian cancer?
Published in Frontiers in oncology (21-09-2022)“…The most common subtype of ovarian cancer (OC) is the high-grade serous ovarian carcinoma (HGSOC), accounting for 70%–80% of all OC deaths. Although HGSOC is a…”
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DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia
Published in Proceedings of the National Academy of Sciences - PNAS (18-01-2011)“…The D2/AKT1/GSK-3β signaling pathway has been involved in the downstream intracellular effects of dopamine, in the pathophysiology of cognitive deficits and…”
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Interaction of childhood urbanicity and variation in dopamine genes alters adult prefrontal function as measured by functional magnetic resonance imaging (fMRI)
Published in PloS one (10-04-2018)“…Brain phenotypes showing environmental influence may help clarify unexplained associations between urban exposure and psychiatric risk. Heritable prefrontal…”
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BDNF rs6265 methylation and genotype interact on risk for schizophrenia
Published in Epigenetics (02-01-2016)“…Epigenetic mechanisms can mediate gene-environment interactions relevant for complex disorders. The BDNF gene is crucial for development and brain plasticity,…”
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Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance
Published in PloS one (22-02-2010)“…Variation of the gene coding for D2 receptors (DRD2) has been associated with risk for schizophrenia and with working memory deficits. A functional intronic…”
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Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia
Published in PloS one (18-06-2014)“…Cognitive dysfunction is central to the schizophrenia phenotype. Genetic and functional studies have implicated Disrupted-in-Schizophrenia 1 (DISC1), a leading…”
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10
Neurocognitive assessment in adult-onset primary cranial cervical dystonia – Response to the letter
Published in Parkinsonism & related disorders (01-08-2014)Get full text
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Factors Associated With Real-Life Functioning in Persons With Schizophrenia in a 4-Year Follow-up Study of the Italian Network for Research on Psychoses
Published in JAMA psychiatry (Chicago, Ill.) (01-05-2021)“…The goal of schizophrenia treatment has shifted from symptom reduction and relapse prevention to functional recovery; however, recovery rates remain low…”
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A Pattern of Cognitive Deficits Stratified for Genetic and Environmental Risk Reliably Classifies Patients With Schizophrenia From Healthy Control Subjects
Published in Biological psychiatry (1969) (15-04-2020)“…Schizophrenia risk is associated with both genetic and environmental risk factors. Furthermore, cognitive abnormalities are established core characteristics of…”
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Impaired cognitive functions in adult-onset primary cranial cervical dystonia
Published in Parkinsonism & related disorders (01-02-2014)“…Abstract Background Adult-onset primary dystonia is thought to be a purely motor disorder. Nevertheless, several studies provided evidence that sensory and…”
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Treatment with Olanzapine is Associated with Modulation of the Default Mode Network in Patients with Schizophrenia
Published in Neuropsychopharmacology (New York, N.Y.) (01-03-2010)“…Earlier studies have shown widespread alterations of functional connectivity of various brain networks in schizophrenia, including the default mode network…”
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The impact of obesity and dyslipidemia on Remdesivir effectiveness in hospitalized patients with SARS-CoV-2-related pneumonia: An observational study
Published in Nutrition, metabolism, and cardiovascular diseases (01-07-2022)“…Remdesivir (GS-5734), an inhibitor of the viral RNA-dependent, RNA polymerase was early identified as a promising therapeutic candidate against COVID-19. Our…”
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Variation in Dopamine D2 and Serotonin 5-HT2A Receptor Genes is Associated with Working Memory Processing and Response to Treatment with Antipsychotics
Published in Neuropsychopharmacology (New York, N.Y.) (01-06-2015)“…Dopamine D2 and serotonin 5-HT2A receptors contribute to modulate prefrontal cortical physiology and response to treatment with antipsychotics in…”
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Heritability of amygdala reactivity to angry faces and its replicable association with the schizophrenia risk locus of miR-137
Published in Journal of psychiatry & neuroscience (01-09-2023)“…Background: Among healthy participants, the interindividual variability of brain response to facial emotions is associated with genetic variation, including…”
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Interaction Between Functional Genetic Variation of DRD2 and Cannabis Use on Risk of Psychosis
Published in Schizophrenia bulletin (01-09-2015)“…Both cannabis use and the dopamine receptor (DRD2) gene have been associated with schizophrenia, psychosis-like experiences, and cognition. However, there are…”
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The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study
Published in European psychiatry (10-11-2020)“…Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and…”
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Familial Risk and a Genome-Wide Supported DRD2 Variant for Schizophrenia Predict Lateral Prefrontal-Amygdala Effective Connectivity During Emotion Processing
Published in Schizophrenia bulletin (06-06-2018)“…Abstract The brain functional mechanisms translating genetic risk into emotional symptoms in schizophrenia (SCZ) may include abnormal functional integration…”
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