Search Results - "ROMAN, Viktor"

Cariprazine alleviates core behavioral deficits in the prenatal valproic acid exposure model of autism spectrum disorder by Román, Viktor, Adham, Nika, Foley, Andrew G., Hanratty, Lynsey, Farkas, Bence, Lendvai, Balázs, Kiss, Béla

“…Rationale Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and interaction and restricted,…”
Get full text

Response-related sensorimotor rhythms under scopolamine and MK-801 exposures in the touchscreen visual discrimination test in rats by Kostyalik, Diána, Kelemen, Kristóf, Lendvai, Balázs, Hernádi, István, Román, Viktor, Lévay, György

“…The human mu rhythm has been suggested to represent an important function in information processing. Rodent homologue rhythms have been assumed though no study…”
Get full text

Tetrabenazine, a vesicular monoamine transporter 2 inhibitor, inhibits vesicular storage capacity and release of monoamine transmitters in mouse brain tissue by Tod, Pál, Varga, Anita, Román, Viktor, Lendvai, Balázs, Pálkovács, Roland, Sperlágh, Beáta, Vizi, E Sylvester

“…Tetrabenazine (TBZ), used for treating hyperkinetic disorders, inhibits vesicular monoamine transporter-2 (VMAT-2), which sequesters monoamines into vesicles…”
Get full text

Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway by Szabó, Dorottya, Tod, Pál, Gölöncsér, Flóra, Román, Viktor, Lendvai, Balázs, Otrokocsi, Lilla, Sperlágh, Beáta

“…•Maternal NLRP3 antagonist treatment counteracts autistm-like phenotype in offspring.•Maternal immune activation triggers P2X7-dependent IL-1β…”
Get full text

The dog (Canis familiaris) as a translational model of autism: It is high time we move from promise to reality by Topál, József, Román, Viktor, Turcsán, Borbála

“…Selecting appropriate animal models for a particular human phenomenon is a difficult but important challenge. The difficulty lies in finding animal behaviors…”
Get full text

Neuronal Dopamine D3 Receptors: Translational Implications for Preclinical Research and CNS Disorders by Kiss, Béla, Laszlovszky, István, Krámos, Balázs, Visegrády, András, Bobok, Amrita, Lévay, György, Lendvai, Balázs, Román, Viktor

“…Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS) and periphery, exerts its actions through five types of receptors…”
Get full text

R-Baclofen Treatment Corrects Autistic-like Behavioral Deficits in the RjIbm(m):FH Fawn-Hooded Rat Strain by Varga, Anita, Kedves, Rita, Sághy, Katalin, Garab, Dénes, Zádor, Ferenc, Lendvai, Balázs, Lévay, György, Román, Viktor

“…The Fawn-hooded rat has long been used as a model for various peripheral and central disorders and the data available indicate that the social behavior of this…”
Get full text

Chronically Restricted Sleep Leads to Depression-Like Changes in Neurotransmitter Receptor Sensitivity and Neuroendocrine Stress Reactivity in Rats by NOVATI, Arianna, ROMAN, Viktor, CETIN, Timur, HAGEWOUD, Roelina, DEN BOER, Johan A, LUITEN, Paul G. M, MEERLO, Peter

“…Frequently disrupted and restricted sleep is a common problem for many people in our Western society. In the long run, insufficient sleep may have…”
Get full text

Measuring sociability of mice using a novel three-chamber apparatus and algorithm of the LABORAS™ system by Kordás, Krisztina, Kis-Varga, Ágnes, Varga, Anita, Eldering, Herman, Bulthuis, Ronald, Lendvai, Balázs, Lévay, György, Román, Viktor

“…•The LABORAS™ sociability system accurately detects social behavior in mice.•The system detects various levels of social behavior in different mouse…”
Get full text

Purkinje cell number-correlated cerebrocerebellar circuit anomaly in the valproate model of autism by Spisák, Tamás, Román, Viktor, Papp, Edit, Kedves, Rita, Sághy, Katalin, Csölle, Cecília Katalin, Varga, Anita, Gajári, Dávid, Nyitrai, Gabriella, Spisák, Zsófia, Kincses, Zsigmond Tamás, Lévay, György, Lendvai, Balázs, Czurkó, András

“…While cerebellar alterations may play a crucial role in the development of core autism spectrum disorder (ASD) symptoms, their pathophysiology on the function…”
Get full text

Convergent cross-species pro-cognitive effects of RGH-235, a new potent and selective histamine H 3 receptor antagonist/inverse agonist by Némethy, Zsolt, Kiss, Béla, Lethbridge, Natasha, Chazot, Paul, Hajnik, Tünde, Tóth, Attila, Détári, László, Schmidt, Éva, Czurkó, András, Kostyalik, Diána, Oláh, Vilmos, Hernádi, István, Balázs, Ottilia, Vizi, E Sylvester, Ledneczki, István, Mahó, Sándor, Román, Viktor, Lendvai, Balázs, Lévay, György

“…The histamine H receptor is a favourable target for the treatment of cognitive deficits. Here we report the in vitro and in vivo profile of RGH-235, a new…”
Get full text

Disrupted Social Hierarchy in Prenatally Valproate-Exposed Autistic-Like Rats by Pelsőczi, Péter, Kelemen, Kristóf, Csölle, Cecília, Nagy, Gábor, Lendvai, Balázs, Román, Viktor, Lévay, György

“…Autism spectrum disorder (ASD) is characterized by impaired socio-communicational function, repetitive and restricted behaviors. Valproic acid (VPA) was…”
Get full text

Intranasal Oxytocin Improves Social Behavior in Laboratory Beagle Dogs ( Canis familiaris ) Using a Custom-Made Social Test Battery by Turcsán, Borbála, Román, Viktor, Lévay, György, Lendvai, Balázs, Kedves, Rita, Petró, Eszter, Topál, József

“…For a long time, oxytocin has been thought to have a generally positive effect on social cognition and prosocial behavior; however, recent results suggested…”
Get full text

Contribution of analog signaling to neurotransmitter interactions and behavior: Role of transporter‐mediated nonquantal dopamine release by Román, Viktor, Kedves, Rita, Kelemen, Kristóf, Némethy, Zsolt, Sperlágh, Beáta, Lendvai, Balázs, Vizi, E. Sylvester

“…Neuronal networks cause changes in behaviorally important information processing through the vesicular release of neurotransmitters governed by the rate and…”
Get full text

Targeted next generation sequencing of a panel of autism-related genes identifies an EHMT1 mutation in a Kleefstra syndrome patient with autism and normal intellectual performance by Bock, István, Németh, Krisztina, Pentelényi, Klára, Balicza, Péter, Balázs, Anna, Molnár, Mária Judit, Román, Viktor, Nagy, József, Lévay, György, Kobolák, Julianna, Dinnyés, András

“…Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with unknown genetic and environmental causation in most of the affected individuals…”
Get full text

Discovery of novel steroidal histamine H 3 receptor antagonists/inverse agonists. Part 2. Versatile steroidal carboxamide derivatives by Ledneczki, István, Némethy, Zsolt, Tapolcsányi, Pál, Éles, János, Greiner, István, Gábor, Eszter, Varga, Balázs, Balázs, Ottilia, Román, Viktor, Lévay, György, Mahó, Sándor

“…To further proceed with our previous work, novel steroid-based histamine H receptor antagonists were identified and characterized. Using an 'amine-to-amide'…”
Get full text

Discovery of novel steroidal histamine H 3 receptor antagonists/inverse agonists by Ledneczki, Istvan, Tapolcsányi, Pál, Gábor, Eszter, Éles, János, Greiner, István, Schmidt, Éva, Némethy, Zsolt, Kedves, Rita Soukupné, Balázs, Ottilia, Román, Viktor, Lévay, György, Mahó, Sándor

“…Emerging from an HTS campaign, novel steroid-based histamine H receptor antagonists were identified and characterized. Structural moieties of the hit compounds…”
Get full text

Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD) by Varga, Eszter, Nemes, Csilla, Bock, István, Táncos, Zsuzsanna, Berzsenyi, Sára, Lévay, György, Román, Viktor, Kobolák, Julianna, Dinnyés, András

“…Peripheral blood mononuclear cells (PBMCs) were collected from a clinically characterized patient with autism spectrum disorder (ASD). The PMBCs were…”
Get full text

Establishment of EHMT1 mutant induced pluripotent stem cell (iPSC) line from a 11-year-old Kleefstra syndrome (KS) patient with autism and normal intellectual performance by Varga, Eszter, Nemes, Csilla, Táncos, Zsuzsanna, Bock, István, Berzsenyi, Sára, Lévay, György, Román, Viktor, Kobolák, Julianna, Dinnyés, András

“…Peripheral blood was collected from a clinically characterized female Kleefstra syndrome patient with a heterozygous, de novo, premature termination codon…”
Get full text

Resveratrol preserves cerebrovascular density and cognitive function in aging mice by Oomen, Charlotte A, Farkas, Eszter, Roman, Viktor, van der Beek, Eline M, Luiten, Paul G M, Meerlo, Peter

“…Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects. Among others, acute…”
Get full text