Search Results - "ROMAGNOLO, Donato F"

Mediterranean Diet and Prevention of Chronic Diseases by Romagnolo, Donato F, Selmin, Ornella I

“…A large body of research data suggests that traditional dietary habits and lifestyle unique to the Mediterranean region (Mediterranean diet, MD) lower the…”
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Epigenetic Activation of BRCA1 by Genistein In Vivo and Triple Negative Breast Cancer Cells Linked to Antagonism toward Aryl Hydrocarbon Receptor by Donovan, Micah G, Selmin, Ornella I, Doetschman, Thomas C, Romagnolo, Donato F

“…Triple negative breast cancers (TNBC) are the most aggressive and lethal breast cancers (BC). The aryl hydrocarbon receptor (AHR) is often overexpressed in…”
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n-6 High Fat Diet Induces Gut Microbiome Dysbiosis and Colonic Inflammation by Selmin, Ornella I., Papoutsis, Andreas J., Hazan, Sabine, Smith, Christopher, Greenfield, Nick, Donovan, Micah G., Wren, Spencer N., Doetschman, Thomas C., Snider, Justin M., Snider, Ashley J., Chow, Sherry H.-H., Romagnolo, Donato F.

“…Background: Concerns are emerging that a high-fat diet rich in n-6 PUFA (n-6HFD) may alter gut microbiome and increase the risk of intestinal disorders…”
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n -6 Linoleic Acid Induces Epigenetics Alterations Associated with Colonic Inflammation and Cancer by Romagnolo, Donato F, Donovan, Micah G, Doetschman, Tom C, Selmin, Ornella I

“…The farnesoid-X-receptor (FXR) protects against inflammation and cancer of the colon through maintenance of intestinal bile acid (BA) homeostasis. Conversely,…”
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Mediterranean Diet: Prevention of Colorectal Cancer by Donovan, Micah G, Selmin, Ornella I, Doetschman, Tom C, Romagnolo, Donato F

“…Colorectal cancer (CRC) is the third most common cancer diagnosis and the second and third leading cause of cancer mortality in men and women, respectively…”
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BRCA1 as target for breast cancer prevention and therapy by Romagnolo, Alberto P G, Romagnolo, Donato F, Selmin, Ornella I

“…The Breast Cancer 1 protein (BRCA1) is a tumor suppressor involved in basic cellular functions necessary for cell replication and DNA synthesis, but reduced…”
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A Villin -Driven Fxr Transgene Modulates Enterohepatic Bile Acid Homeostasis and Response to an n -6-Enriched High-Fat Diet by Wren, Spencer N, Donovan, Micah G, Selmin, Ornella I, Doetschman, Tom C, Romagnolo, Donato F

“…A diet high in -6 polyunsaturated fatty acids (PUFAs) may contribute to inflammation and tissue damage associated with obesity and pathologies of the colon and…”
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Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells by Degner, Stephanie C, Papoutsis, Andreas J, Selmin, Ornella, Romagnolo, Donato F

“…Ligands of the aryl hydrocarbon receptor (AhR) include the environmental xenobiotic 2,3,7,8 tetrachlorodibenzo(p)dioxin (TCDD), polycyclic aryl hydrocarbons,…”
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BRCA-1 promoter hypermethylation and silencing induced by the aromatic hydrocarbon receptor-ligand TCDD are prevented by resveratrol in MCF-7 Cells by Papoutsis, Andreas J, Borg, Jamie L, Selmin, Ornella I, Romagnolo, Donato F

“…Epigenetic mechanisms may contribute to reduced expression of the tumor suppressor gene BRCA-1 in sporadic breast cancers. Through environmental exposure and…”
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Nuclear Receptors and Epigenetic Regulation: Opportunities for Nutritional Targeting and Disease Prevention by Romagnolo, Donato F., Zempleni, Janos, Selmin, Ornella I.

“…Posttranslational modifications of histones, alterations in the recruitment and functions of non-histone proteins, DNA methylation, and changes in expression…”
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Bisphenols and Risk of Breast Cancer: A Narrative Review of the Impact of Diet and Bioactive Food Components by Stillwater, Barbara J, Bull, Ashleigh C, Romagnolo, Donato F, Neumayer, Leigh A, Donovan, Micah G, Selmin, Ornella I

“…Data from preclinical studies suggest a link between increased risk of breast cancer and exposure to bisphenols at doses below what the United States Food and…”
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Do Olive and Fish Oils of the Mediterranean Diet Have a Role in Triple Negative Breast Cancer Prevention and Therapy? An Exploration of Evidence in Cells and Animal Models by Donovan, Micah G., Selmin, Ornella I., Stillwater, Barbara J., Neumayer, Leigh A., Romagnolo, Donato F.

“…Breast cancer is the most common malignancy and cause of cancer-related mortality among women worldwide. Triple negative breast cancers (TNBC) are the most…”
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Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer by Selmin, Ornella I., Donovan, Micah G., Stillwater, Barbara J., Neumayer, Leigh, Romagnolo, Donato F.

“…Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR)…”
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Phytoalexins in cancer prevention by Romagnolo, Donato F, Davis, Cindy D, Milner, John A

“…Plant phytoalexins are a class of low molecular weight compounds that accumulate in response to biotic and abiotic elicitors such as pathogens, wounding,…”
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Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: effects on the expression of G1-restriction points in breast and colon cancer cells by Kemp, Michael Q, Jeffy, Brandon D, Romagnolo, Donato F

“…Previous reports have documented the antiproliferative properties of a mixture of conjugated isomers (CLA) of linoleic acid [LA (18:2)]. In this study, we…”
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The ligand status of the aromatic hydrocarbon receptor modulates transcriptional activation of BRCA-1 promoter by estrogen by HOCKINGS, Jennifer K, THORNE, Patricia A, KEMP, Michael Q, MORGAN, Sherif S, SELMIN, Ornella, ROMAGNOLO, Donato F

“…In sporadic breast cancers, BRCA-1 expression is down-regulated in the absence of mutations in the BRCA-1 gene. This suggests that disruption of BRCA-1…”
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Flavonoids and Cancer Prevention: A Review of the Evidence by Romagnolo, Donato F, Selmin, Ornella I

“…The objective of this work is to review data from epidemiological and preclinical studies addressing the potential benefits of diets based on flavonoids for…”
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Cyclooxygenase-2 Promoter Activation by the Aromatic Hydrocarbon Receptor in Breast Cancer MCF-7 Cells: Repressive Effects of Conjugated Linoleic Acid by Degner, Stephanie C., Kemp, Michael Q., Hockings, Jennifer K., Romagnolo, Donato F.

“…The role of the aromatic hydrocarbon receptor (AhR) in transcriptional regulation of the human cyclooxygenase-2 (COX-2) gene remains elusive. We report that…”
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Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation by Donovan, Micah G., Wren, Spencer N., Cenker, Mikia, Selmin, Ornella I., Romagnolo, Donato F.

“…Breast cancer (BC) is the most common cancer and second leading cause of cancer mortality in women worldwide. Validated biomarkers enhance efforts for early…”
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An Estrogen Receptor-α/p300 Complex Activates the BRCA-1 Promoter at an AP-1 Site That Binds Jun/Fos Transcription Factors: Repressive Effects of p53 on BRCA-1 Transcription by Jeffy, Brandon D., Hockings, Jennifer K., Kemp, Michael Q., Morgan, Sherif S., Hager, Jill A., Beliakoff, Jason, Whitesell, Luke J., Bowden, G. Timothy, Romagnolo, Donato F.

“…One of the puzzles in cancer predisposition is that women carrying BRCA-1 mutations preferentially develop tumors in epithelial tissues of the breast, ovary…”
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