Search Results - "ROLO, A. P"

Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice by Teodoro, J S, Zouhar, P, Flachs, P, Bardova, K, Janovska, P, Gomes, A P, Duarte, F V, Varela, A T, Rolo, A P, Palmeira, C M, Kopecký, J

“…Objective: Besides their role in lipid absorption, bile acids (BAs) can act as signalling molecules. Cholic acid was shown to counteract obesity and associated…”
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The influence of dietary conditions in the effects of resveratrol on hepatic steatosis by Milton-Laskibar, I, Aguirre, L, Gómez-Zorita, S, Rolo, A P, Portillo, M P

“…Non-alcoholic fatty liver disease (NAFLD) is considered the major cause for the development of chronic liver alterations. Hepatic steatosis is the most benign…”
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Bile acids affect liver mitochondrial bioenergetics : Possible relevance for cholestasis therapy by ROLO, Anabela P, OLIVEIRA, Paulo J, MORENO, Antonio J. M, PALMEIRA, Carlos M

“…It has been pointed out that intracellular accumulation of bile acids cause hepatocyte injury in cholestatic disease process. This study was aimed to test if…”
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Role of Mitochondrial Dysfunction in Combined Bile Acid–Induced Cytotoxicity: The Switch Between Apoptosis and Necrosis by Rolo, Anabela P., Palmeira, Carlos M., Holy, Jon M., Wallace, Kendall B.

“…The goal of this investigation was to determine whether chenodeoxycholic acid (CDCA)-induced apoptosis is prevented by ursodeoxycholic acid (UDCA) or…”
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Dibenzofuran-induced mitochondrial dysfunction: Interaction with ANT carrier by Duarte, F.V., Gomes, A.P., Teodoro, J.S., Varela, A.T., Moreno, A.J.M., Rolo, A.P., Palmeira, C.M.

“…•DBF exposure negatively affects liver mitochondria phosphorylative system.•DBF increases the threshold to the induction of the mitochondrial permeability…”
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Mitochondrially-mediated toxicity of bile acids by Palmeira, Carlos M., Rolo, Anabela P.

“…In the healthy hepatocyte, uptake of bile acids across the basolateral membrane and export via the canalicular export pump, are tightly coupled. Impairment of…”
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Cholestasis induced by chronic treatment with α-naphthyl-isothiocyanate (ANIT) affects rat renal mitochondrial bioenergetics by FERREIRA, F. M, OLIVEIRA, P. J, ROLO, A. P, SANTOS, M. S, MORENO, A. J, DA CUNHA, M. F, SEICA, R, PALMEIRA, C. M

“…Chronic cholestasis is characteristic of many human liver diseases. Renal injury has been often associated with this type of disease. The aim of this study was…”
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Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria by Rolo, A P, Oliveira, P J, Moreno, A J, Palmeira, C M

“…Several reports support the concept that bile acids may be cytotoxic during cholestatic disease process by causing mitochondrial dysfunction. Here we report…”
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Insulin attenuates diabetes-related mitochondrial alterations: a comparative study by Moreira, P I, Rolo, A P, Sena, C, Seiça, R, Oliveira, C R, Santos, M S

“…This study evaluated and compared the effect of insulin treatment on the status of brain, heart and kidney mitochondria isolated from 12-week streptozotocin…”
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Interactions of combined bile acids on hepatocyte viability: cytoprotection or synergism by Rolo, Anabela P, Palmeira, Carlos M, Wallace, Kendall B

“…Cholestasis results from hepatocyte dysfunction due to the accumulation of bile acids in the cell, many of which are known to be cytotoxic. Recent evidence…”
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Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with α-naphthyl-isothiocyanate (ANIT) by Palmeira, Carlos M., Ferreira, Fernanda M., Rolo, Anabela P., Oliveira, Paulo J., Santos, Maria S., Moreno, António J., Cipriano, Maria A., Martins, Maria I., Seiça, Raquel

“…This study was designed to evaluate the effects of long-term treatment with α-naphthyl-isothiocyanate (ANIT) on liver histology and at the mitochondrial…”
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Inhibitory effect of carvedilol in the high-conductance state of the mitochondrial permeability transition pore by Oliveira, Paulo J., Coxito, Pedro M., Rolo, Anabela P., Santos, Dario L., Palmeira, Carlos M., Moreno, António J.M.

“…The mitochondrial permeability transition is a widely studied, but poorly understood, phenomenon in mitochondrial bioenergetics. It has been recognised that…”
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Hyperglycemia decreases mitochondrial function: The regulatory role of mitochondrial biogenesis by Palmeira, Carlos M., Rolo, Anabela P., Berthiaume, Jessica, Bjork, James A., Wallace, Kendall B.

“…Increased generation of reactive oxygen species (ROS) is implicated in “glucose toxicity” in diabetes. However, little is known about the action of glucose on…”
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Improved Efficiency of Hepatic Mitochondrial Function in Rats with Cholestasis Induced by an Acute Dose of α-Naphthylisothiocyanate by Rolo, Anabela P., Oliveira, Paulo J., Seiça, Raquel, Santos, Maria S., Moreno, António J., Palmeira, Carlos M.

“…Cholestasis is a feature of many chronic human liver diseases. Previous studies pointed out an impairment of mitochondrial function as a cause of hepatocyte…”
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Protective effect of carvedilol on chenodeoxycholate induction of the permeability transition pore by Rolo, Anabela P., Oliveira, Paulo J., Moreno, Antonio J.M., Palmeira, Carlos M.

“…Intracellular accumulation of toxic, hydrophobic bile acids has been proposed as one of the putative final common pathways leading to cholestatic liver injury…”
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Decreased susceptibility of heart mitochondria from diabetic GK rats to mitochondrial permeability transition induced by calcium phosphate by Oliveira, P J, Rolo, A P, Seiça, R, Palmeira, C M, Santos, M S, Moreno, A J

“…Type 2 diabetes (or non-insulin dependent diabetes mellitus, NIDDM) is a common metabolic disease in man. The Goto-Kakizaki (GK) rat has been designed as a…”
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Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress by Rolo, Anabela P., Palmeira, Carlos M.

“…Hyperglycemia resulting from uncontrolled glucose regulation is widely recognized as the causal link between diabetes and diabetic complications. Four major…”
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Corrigendum to “European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” [Redox Biol. 13 (2017) 94–162] by Egea, J., Fabregat, I., Kietzmann, T., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Afonso, C.B., Andreadou, I., Antelmann, H., Antunes, F., Aslan, M., Bachschmid, M.M., Barbosa, R.M., Bernlohr, D., Bertrán, E., Bottari, S.P., Brito, P.M., Carrara, G., Casas, A.I., Chatzi, A., Conrad, M., Cooke, M.S., My-Chan Dang, P., De Smet, B., Dunn, J.D., Edson, A.J., El-Benna, J., Ferdinandy, P., Fladmark, K.E., Förstermann, U., Giniatullin, R., Giricz, Z., Griffiths, H., Hanf, A., Hernansanz-Agustín, P., Huang, J., Ilikay, S., Jansen-Dürr, P., Kalyanaraman, B., Kaminskyy, D., Kleanthous, M., Klotz, L.O., Korac, B., Koziel, R., Krieg, T., Laranjinha, J., Li, H., Matsui, R., Meredith, S.P., Messens, J., Miguel, V., Mikhed, Y., Milisav, I., Miranda-Vizuete, A., Mojović, M., Mouthuy, P.A., Münzel, T., Muzykantov, V., Nguyen, I.T.N., Oliveira, N.G., Palmeira, C.M., Papaevgeniou, N., Pavićević, A., Pedre, B., Pircalabioru, G.G., Pitt, A.R., Poulsen, H.E., Prieto, I., Robledinos-Antón, N., Rousset, F., Ruskovska, T., Saraiva, N., Schröder, K., Semen, K., Seredenina, T., Shakirzyanova, A., Smith, G.L., Soldati, T., Sousa, B.C., Spickett, C.M., Stancic, A., Stasia, M.J., Steinbrenner, H., Tuncay, E., Turan, B., Ursini, F., Vacek, J., Valentová, K., Van Breusegem, F., Yalçın, A.S., Yelisyeyeva, O., Žarković, N., Touyz, R.M., Grune, T., Lamas, S., Schmidt, H.H.H.W., Di Lisa, F., Daiber, A.

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Indirubin-3′-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction by Varela, Ana T., Gomes, Ana P., Simões, Anabela M., Teodoro, João S., Duarte, Filipe V., Rolo, Anabela P., Palmeira, Carlos M.

“…Indirubin, a red colored 3,2′-bisindole isomer, is a component of Indigo naturalis and is an active ingredient used in traditional Chinese medicine for the…”
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Exposure to dibenzofuran affects lung mitochondrial function in vitro by Duarte, Filipe V., Simões, Anabela M., Teodoro, João S., Rolo, Anabela P., Palmeira, Carlos M.

“…Environmental pollutants, such as dioxins and furans, are extremely toxic and related with pulmonary diseases development. Impairment of mitochondrial function…”
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