Search Results - "ROLFS, Frank"

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases by Beekhof, Robin, van Alphen, Carolien, Henneman, Alex A, Knol, Jaco C, Pham, Thang V, Rolfs, Frank, Labots, Mariette, Henneberry, Evan, Le Large, Tessa YS, de Haas, Richard R, Piersma, Sander R, Vurchio, Valentina, Bertotti, Andrea, Trusolino, Livio, Verheul, Henk MW, Jimenez, Connie R

“…Identifying hyperactive kinases in cancer is crucial for individualized treatment with specific inhibitors. Kinase activity can be discerned from global…”
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VRK1 Regulates Sensitivity to Oxidative Stress by Altering Histone Epigenetic Modifications and the Nuclear Phosphoproteome in Tumor Cells by Navarro-Carrasco, Elena, Monte-Serrano, Eva, Campos-Díaz, Aurora, Rolfs, Frank, de Goeij-de Haas, Richard, Pham, Thang V, Piersma, Sander R, González-Alonso, Paula, Jiménez, Connie R, Lazo, Pedro A

“…The chromatin organization and its dynamic remodeling determine its accessibility and sensitivity to DNA damage oxidative stress, the main source of endogenous…”
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Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors by Bhin, Jinhyuk, Paes Dias, Mariana, Gogola, Ewa, Rolfs, Frank, Piersma, Sander R., de Bruijn, Roebi, de Ruiter, Julian R., van den Broek, Bram, Duarte, Alexandra A., Sol, Wendy, van der Heijden, Ingrid, Andronikou, Christina, Kaiponen, Taina S., Bakker, Lara, Lieftink, Cor, Morris, Ben, Beijersbergen, Roderick L., van de Ven, Marieke, Jimenez, Connie R., Wessels, Lodewyk F.A., Rottenberg, Sven, Jonkers, Jos

“…BRCA1 and BRCA2 both function in DNA double-strand break repair by homologous recombination (HR). Due to their HR defect, BRCA1/2-deficient cancers are…”
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Dual Role of the Antioxidant Enzyme Peroxiredoxin 6 in Skin Carcinogenesis by ROLFS, Frank, HUBER, Marcel, WERNER, Sabine, GRUBER, Florian, BÖHM, Friederike, PFISTER, Herbert J, BOCHKOV, Valery N, TSCHACHLER, Erwin, DUMMER, Reinhard, HOHL, Daniel, SCHÄFER, Matthias

“…The antioxidant enzyme peroxiredoxin 6 (Prdx6) is a key regulator of the cellular redox balance, particularly under stress conditions. We identified Prdx6 as…”
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Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations by Rolfs, Frank, Huber, Marcel, Kuehne, Andreas, Kramer, Stefan, Haertel, Eric, Muzumdar, Sukalp, Wagner, Johanna, Tanner, Yasmine, Böhm, Friederike, Smola, Sigrun, Zamboni, Nicola, Levesque, Mitchell P, Dummer, Reinhard, Beer, Hans-Dietmar, Hohl, Daniel, Werner, Sabine, Schäfer, Matthias

“…Pharmacologic activation of the transcription factor NRF2 has been suggested to offer a strategy for cancer prevention. In this study, we present evidence from…”
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INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases by Beekhof, Robin, Alphen, Carolien, Henneman, Alex A, Knol, Jaco C, Pham, Thang V, Rolfs, Frank, Labots, Mariette, Henneberry, Evan, Le Large, Tessa YS, Haas, Richard R, Piersma, Sander R, Vurchio, Valentina, Bertotti, Andrea, Trusolino, Livio, Verheul, Henk MW, Jimenez, Connie R

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Feasibility of Phosphoproteomics on Leftover Samples After RNA Extraction With Guanidinium Thiocyanate by Rolfs, Frank, Piersma, Sander R., Dias, Mariana Paes, Jonkers, Jos, Jimenez, Connie R.

“…In daily practice, different types of biomolecules are usually extracted for large-scale “omics” analysis with tailored protocols. However, when sample…”
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Inferring kinase activity from phosphoproteomic data: Tool comparison and recent applications by Piersma, Sander R., Valles‐Marti, Andrea, Rolfs, Frank, Pham, Thang V., Henneman, Alex A., Jiménez, Connie R.

“…Aberrant cellular signaling pathways are a hallmark of cancer and other diseases. One of the most important signaling mechanisms involves protein…”
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Secretome processing for proteomics: A methods comparison by Almeida‐Marques, Catarina, Rolfs, Frank, Piersma, Sander R., Bijnsdorp, Irene V., Pham, Thang V., Knol, Jaco C., Jimenez, Connie R.

“…The cancer cell secretome comprises a treasure‐trove for biomarkers since it reflects cross‐talk between tumor cells and their surrounding environment with…”
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NF-κB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma by Köhler, Ulrike A, Böhm, Friederike, Rolfs, Frank, Egger, Michèle, Hornemann, Thorsten, Pasparakis, Manolis, Weber, Achim, Werner, Sabine

“…Graphical abstract…”
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Loss of VRK1 alters the nuclear phosphoproteome in the DNA damage response to doxorubicin by Navarro-Carrasco, Elena, Campos-Díaz, Aurora, Monte-Serrano, Eva, Rolfs, Frank, de Goeij-de Haas, Richard, Pham, Thang V., Piersma, Sander R., Jiménez, Connie R., Lazo, Pedro A.

“…Dynamic chromatin remodeling requires regulatory mechanisms for its adaptation to different nuclear function, which are likely to be mediated by signaling…”
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Feasibility of phosphoproteomics to uncover oncogenic signalling in secreted extracellular vesicles using glioblastoma-EGFRVIII cells as a model by Bijnsdorp, Irene V., Schelfhorst, Tim, Luinenburg, Mark, Rolfs, Frank, Piersma, Sander R., de Haas, Richard R., Pham, Thang V., Jimenez, Connie R.

“…Cancer cells secrete extracellular vesicles (EVs) that contain molecular information, including proteins and RNA. Oncogenic signalling can be transferred via…”
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Transcriptional Activities of the Sleeping Beauty Transposon and Shielding Its Genetic Cargo With Insulators by Walisko, Oliver, Schorn, Andrea, Rolfs, Frank, Devaraj, Anantharam, Miskey, Csaba, Izsvák, Zsuzsanna, Ivics, Zoltán

“…The Sleeping Beauty (SB) transposable element shows efficient transposition in human cells, and provides long-term transgene expression in preclinical animal…”
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Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers by Zingg, Daniel, Bhin, Jinhyuk, Yemelyanenko, Julia, Kas, Sjors M., Rolfs, Frank, Lutz, Catrin, Lee, Jessica K., Klarenbeek, Sjoerd, Silverman, Ian M., Annunziato, Stefano, Chan, Chang S., Piersma, Sander R., Eijkman, Timo, Badoux, Madelon, Gogola, Ewa, Siteur, Bjørn, Sprengers, Justin, de Klein, Bim, de Goeij-de Haas, Richard R., Riedlinger, Gregory M., Ke, Hua, Madison, Russell, Drenth, Anne Paulien, van der Burg, Eline, Schut, Eva, Henneman, Linda, van Miltenburg, Martine H., Proost, Natalie, Zhen, Huiling, Wientjens, Ellen, de Bruijn, Roebi, de Ruiter, Julian R., Boon, Ute, de Korte-Grimmerink, Renske, van Gerwen, Bastiaan, Féliz, Luis, Abou-Alfa, Ghassan K., Ross, Jeffrey S., van de Ven, Marieke, Rottenberg, Sven, Cuppen, Edwin, Chessex, Anne Vaslin, Ali, Siraj M., Burn, Timothy C., Jimenez, Connie R., Ganesan, Shridar, Wessels, Lodewyk F. A., Jonkers, Jos

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Re-assessment of the high-grade serous ovarian cancer phosphoproteome – Identification of kinase candidates in TCGA tumors for future clinical intervention by Rolfs, Frank, Piersma, Sander R., Jimenez, Connie R.

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Peroxiredoxin 6 in skin carcinogenesis by Rolfs, Frank, Schäfer, Matthias, Werner, Sabine

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Erratum To: INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases by Beekhof, Robin, van Alphen, Carolien, Henneman, Alex A, Knol, Jaco C, Pham, Thang V, Rolfs, Frank, Labots, Mariette, Henneberry, Evan, Le Large, Tessa YS, de Haas, Richard R, Piersma, Sander R, Vurchio, Valentina, Bertotti, Andrea, Trusolino, Livio, Verheul, Henk MW, Jimenez, Connie R

“…Graphical Abstract…”
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