Search Results - "ROLAN, Paul E"

Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain by Grace, Peter M, Rolan, Paul E, Hutchinson, Mark R

“…Highlight ► This review demonstrates how T cells are likely to contribute to the underlying pathology of neuropathic pain in the central nervous system…”
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First-In-Human, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study of BG00010, a Glial Cell Line-Derived Neurotrophic Factor Family Member, in Subjects with Unilateral Sciatica by Rolan, Paul E, O'Neill, Gilmore, Versage, Eve, Rana, Jitesh, Tang, Yongqiang, Galluppi, Gerald, Aycardi, Ernesto

“…To evaluate the safety, tolerability, and pharmacokinetics of single doses of BG00010 (neublastin, artemin, enovin) in subjects with unilateral sciatica. This…”
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Increased responsiveness of peripheral blood mononuclear cells to in vitro TLR 2, 4 and 7 ligand stimulation in chronic pain patients by Kwok, Yuen H, Hutchinson, Mark R, Gentgall, Melanie G, Rolan, Paul E

“…Glial activation via Toll-like receptor (TLR) signaling has been shown in animals to play an important role in the initiation and establishment of chronic…”
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Androgens, Endometriosis and Pain by Evans, Susan F., Hull, M. Louise, Hutchinson, Mark R., Rolan, Paul E.

“…The intriguing relationship between androgens, endometriosis and chronic pain continues to unfold. Determining this relationship is of crucial importance to…”
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TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers by Kwok, Yuen H, Tuke, Jonathan, Nicotra, Lauren L, Grace, Peter M, Rolan, Paul E, Hutchinson, Mark R

“…Chronic pain patients have increased peripheral blood mononuclear cell Interkeukin-1β production following TLR2 and TLR4 simulation. Here we have used a…”
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Drug Interactions with Triptans: Which are Clinically Significant? by Rolan, Paul E.

“…The triptans are a group of compounds with high efficacy for the acute treatment of migraine and cluster headache. They have a relatively wide therapeutic…”
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The comorbidities of dysmenorrhea: a clinical survey comparing symptom profile in women with and without endometriosis by Evans, Susan F, Brooks, Tiffany A, Esterman, Adrian J, Hull, M Louise, Rolan, Paul E

“…Dysmenorrhea is a common disorder that substantially disrupts the lives of young women. The frequency of 14 associated symptoms both within and outside the…”
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The pharmacokinetics and pharmacodynamics of single dose (R)‐ and (S)‐warfarin administered separately and together: relationship to VKORC1 genotype by Maddison, John, Somogyi, Andrew A., Jensen, Berit P., James, Heather M., Gentgall, Melanie, Rolan, Paul E.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The contribution of (S)‐warfarin to the clinical effect of rac‐warfarin is well understood. The extent to which…”
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SAFETY AND EFFICACY OF PRO ANP 31-67 IN CARDIORENAL SYNDROME: A FIRST-IN-HUMAN TRIAL by Delacroix, Sinny, Chokka, Ramesh, Nelson, Adam, Sidharta, Samuel, Teo, Karen, Tuke, Jonathan, Upton, Richard, Rolan, Paul E, Worthley, Stephen

“…Conclusions Treatment with pro ANP 31-67 atop standard of care in patients with congestive heart failure and renal impairment improved renal function with…”
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A novel animal model of graded neuropathic pain: Utility to investigate mechanisms of population heterogeneity by Grace, Peter M., Hutchinson, Mark R., Manavis, Jim, Somogyi, Andrew A., Rolan, Paul E.

“…▶ Varied sciatic nerve chromic gut sutures results in graded allodynia. ▶ Varied sciatic nerve chromic gut sutures associated with graded glial activation. ▶…”
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Chronic tension-type headache is associated with impaired motor learning by Vallence, Ann-Maree, Smith, Ashleigh, Tabor, Abby, Rolan, Paul E, Ridding, Michael C

“…Supraspinal activity-dependent neuroplasticity may be important in the transition from acute to chronic pain. We examined neuroplasticity in a cortical region…”
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Paradoxical topiramate-induced hyperphagia successfully treated with phentermine in a woman with migraine by Johnson, Jacinta L, Rolan, Paul E

“…Abstract We report a 49-year-old female migraineur who experienced paradoxical hyperphagia and concurrent intrusive food thoughts leading to rapid weight gain…”
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Toll-Like Receptor Responsiveness of Peripheral Blood Mononuclear Cells in Young Women with Dysmenorrhea by Evans, Susan F, Kwok, Yuen H, Solterbeck, Ann, Liu, Jiajun, Hutchinson, Mark R, Hull, M Louise, Rolan, Paul E

“…Dysmenorrhea is a common disorder that substantially disrupts the lives of young women. To determine whether there is evidence of activation of the innate…”
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Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model by Grace, Peter M., Hurley, Daniel, Barratt, Daniel T., Tsykin, Anna, Watkins, Linda R., Rolan, Paul E., Hutchinson, Mark R.

“…J. Neurochem. (2012) 122, 976–994. A quantitative, peripherally accessible biomarker for neuropathic pain has great potential to improve clinical outcomes…”
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Glial Attenuation With Ibudilast in the Treatment of Medication Overuse Headache: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial of Efficacy and Safety by Johnson, Jacinta L., Kwok, Yuen H., Sumracki, Nicole M., Swift, James E., Hutchinson, Mark R., Johnson, Kirk, Williams, Desmond B., Tuke, Jonathon, Rolan, Paul E.

“…Background Medication overuse headache (MOH) is a condition bordering between a chronic pain condition and a substance dependence disorder. Activation of…”
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Sex differences in mechanical allodynia: how can it be preclinically quantified and analyzed? by Nicotra, Lauren, Tuke, Jonathan, Grace, Peter M, Rolan, Paul E, Hutchinson, Mark R

“…Translating promising preclinical drug discoveries to successful clinical trials remains a significant hurdle in pain research. Although animal models have…”
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Utility of saccadic eye movement analysis as an objective biomarker to detect the sedative interaction between opioids and sleep deprivation in opioid-naive and opioid-tolerant populations by Grace, P M, Stanford, T, Gentgall, M, Rolan, P E

“…Analysis of saccadic eye movements (SEMs) has previously been used to detect drug- and sleep-deprivation-induced sedation, but never in combination. We…”
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Effect of citalopram on plasma levels of oral theophylline by Møller, Svend Erik, Larsen, Frank, Pitsiu, Maria, Rolan, Paul E.

“…Background: Citalopram and theophylline may be prescribed together to treat patients with depression and asthmatic disease. Because theophylline has a low…”
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Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain by Grace, Peter M, Hutchinson, Mark R, Bishop, Alan, Somogyi, Andrew A, Mayrhofer, Graham, Rolan, Paul E

“…Research highlights ► Intraperitoneal adoptive transfer of peripheral immune cells potentiates chronic constriction injury-induced allodynia. ► Peripheral…”
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Pharmacokinetics of high-dose buprenorphine following single administration of sublingual tablet formulations in opioid naïve healthy male volunteers under a naltrexone block by MCALEER, Sarah D, MILLS, Richard J, POLACK, Torsten, HUSSAIN, Tanweer, ROLAN, Paul E, GIBBS, Alan D, MULLINS, Frank G. P, HUSSEIN, Ziad

“…Sublingual buprenorphine formulations have been developed as treatments for opioid dependence. In three studies, opioid naïve healthy male subjects received…”
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