Search Results - "ROHRER, Susan P"

Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus by Clark, Janet A., Pai, Lee-Yuh, Flick, Rosemarie Beth, Rohrer, Susan P.

“…Recently a novel tryptophan hydroxylase isoform (TPH2) was identified and shown to be highly expressed in the central nervous system (CNS). Hormonal effects on…”
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Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs by Chen, Helen Y., Kim, Seongkon, Wu, Jane Y., Birzin, Elizabeth T., Chan, Wanda, Yang, Yi Tien, Dahllund, Johanna, DiNinno, Frank, Rohrer, Susan P., Schaeffer, James M., Hammond, Milton L.

“…A class of dihydrobenzoxathiins 1 exhibiting a high degree of selectivity for ERα over ERβ has been discovered. The SAR of dihydrobenzoxathiins with…”
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Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans by Liu, Jian, Birzin, Elizabeth T., Chan, Wanda, Yang, Yi Tien, Pai, Lee-Yuh, DaSilva, Carolyn, Hayes, Edward C., Mosley, Ralph T., DiNinno, Frank, Rohrer, Susan P., Schaeffer, James M., Hammond, Milton L.

“…The isochroman and isothiochroman compounds were synthesized as potent estrogen receptor ligands. The ring oxygen and sulfur analogs of lasofoxifene, 1a and…”
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Immunolocalization of Estrogen Receptor β in the Mouse Brain: Comparison with Estrogen Receptor α by Mitra, Sudha Warrier, Hoskin, Elena, Yudkovitz, Joel, Pear, Lisset, Wilkinson, Hilary A, Hayashi, Shinji, Pfaff, Donald W, Ogawa, Sonoko, Rohrer, Susan P, Schaeffer, James M, McEwen, Bruce S, Alves, Stephen E

“…Estrogen receptor α (ERα) and ERβ are members of the steroid nuclear receptor family that modulate gene transcription in an estrogen-dependent manner. ER mRNA…”
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17β-Estradiol-induced antidepressant-like effect in the forced swim test is absent in estrogen receptor-β knockout (Berko) mice by ROCHA, Beatriz A, FLEISCHER, Rebecca, SCHAEFFER, James M, ROHRER, Susan P, HICKEY, Gerry J

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Estrogen receptor ligands. Part 14: Application of novel antagonist side chains to existing platforms by Blizzard, Timothy A., Morgan, Jerry D., Chan, Wanda, Birzin, Elizabeth T., Pai, Lee-Yuh, Hayes, Edward C., DaSilva, Carolyn A., Mosley, Ralph T., Yang, Yi Tien, Rohrer, Susan P., DiNinno, Frank, Hammond, Milton L.

“…Two novel side chains which had previously been found to enhance antagonist activity in the dihydrobenzoxathiin SERM series were applied to three existing…”
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6H-Benzo[c]chromen-6-one derivatives as selective ERβ agonists by Sun, Wanying, Cama, Lovji D., Birzin, Elizabeth T., Warrier, Sudha, Locco, Louis, Mosley, Ralph, Hammond, Milton L., Rohrer, Susan P.

“…A series of 6H-benzo[c]chromen-6-one and 6H-benzo[c]chromene derivatives were prepared. Many of the analogs were found to be potent and selective ERβ agonists…”
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Estrogen receptor-β regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe by Gundlah, Chrisana, Alves, Stephen E., Clark, Janet A., Pai, Lee-Yuh, Schaeffer, James M., Rohrer, Susan P.

“…Distinct expression patterns of estrogen receptor (ER)-α and ER-β are displayed in the murine central nervous system. ER-β is the predominant form of the…”
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Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor α Modulators by Kim, Seongkon, Wu, Jane Y, Birzin, Elizabeth T, Frisch, Katalin, Chan, Wanda, Pai, Lee-Yuh, Yang, Yi Tien, Mosley, Ralph T, Fitzgerald, Paula M. D, Sharma, Nandini, Dahllund, Johanna, Thorsell, Ann-Gerd, DiNinno, Frank, Rohrer, Susan P, Schaeffer, James M, Hammond, Milton L

“…The discovery and synthesis of dihydrobenzoxathiins as potent, ERα subtype selective ligands are described. The most active analogue, 4-D, was found to be…”
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Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERα by Dykstra, Kevin D., Guo, Liangqin, Birzin, Elizabeth T., Chan, Wanda, Yang, Yi Tien, Hayes, Edward C., DaSilva, Carolyn A., Pai, Lee-Yuh, Mosley, Ralph T., Kraker, Bryan, Fitzgerald, Paula M.D., DiNinno, Frank, Rohrer, Susan P., Schaeffer, James M., Hammond, Milton L.

“…A novel class of indole ligands for estrogen receptor α have been discovered which exhibit potent affinity and high selectivity. Substitution of the…”
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Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists by CHANGYOU ZHOU, LIANGQIN GUO, KANG CHENG, SCHAEFFER, James M, PATCHETT, Arthur A, LIHU YANG, MORRIELLO, Greg, PASTERNAK, Alex, PAN, Yanping, ROHRER, Susan P, BIRZIN, Elizebeth T, HUSKEY, Su-Er Wu, JACKS, Tom, SCHLEIM, Klaus D

“…N-Substituted nipecotic and iso-nipecotic amides of beta-methylTrpLys tert-butyl ester were found to be novel, selective and potent agonists of the…”
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Identification and characterization of lipopolysaccharide binding protein (LBP) as an estrogen receptor α specific serum biomarker by Chisamore, Michael J., Hong, Kwok-lam Karen, Cheng, Chun, Alves, Stephen E., Rohrer, Susan P., Wilkinson, Hilary A.

“…Estrogen Receptor α (ERα) and Estrogen Receptor β (ERβ) are steroid nuclear receptors that transduce estrogen signaling to control diverse physiological…”
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Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers by Blizzard, Timothy A., DiNinno, Frank, Morgan, Jerry D., Chen, Helen Y., Wu, Jane Y., Kim, Seongkon, Chan, Wanda, Birzin, Elizabeth T., Yang, Yi Tien, Pai, Lee-Yuh, Fitzgerald, Paula M.D., Sharma, Nandini, Li, Ying, Zhang, Zhoupeng, Hayes, Edward C., DaSilva, Carolyn A., Tang, Wei, Rohrer, Susan P., Schaeffer, James M., Hammond, Milton L.

“…A series of benzoxathiin SERAMs was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity,…”
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Antidiabetic Activity of a Highly Potent and Selective Nonpeptide Somatostatin Receptor Subtype-2 Agonist by Strowski, Mathias Z, Cashen, Doreen E, Birzin, Elizabeth T, Yang, Lihu, Singh, Vandana, Jacks, Thomas M, Nowak, Krzysztof W, Rohrer, Susan P, Patchett, Arthur A, Smith, Roy G, Schaeffer, James M

“…Somatostatin inhibits both glucagon and insulin secretion. Glucagon significantly contributes to hyperglycemia in type 2 diabetes. Despite its function in the…”
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Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity by Chen, Helen Y., Dykstra, Kevin D., Birzin, Elizabeth T., Frisch, Katalin, Chan, Wanda, Yang, Yi T., Mosley, Ralph T., DiNinno, Frank, Rohrer, Susan P., Schaeffer, James M., Hammond, Milton L.

“…A class of flavanoids exhibiting a high degree of selectivity for ERα over ERβ has been discovered. The most active analogue 6 was found to be 66-fold…”
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Effects of Heterocyclic Aromatic Substituents on Binding Affinities at Two Distinct Sites of Somatostatin Receptors. Correlation with the Electrostatic Potential of the Substituents by Prasad, Vidya, Birzin, Elizabeth T, McVaugh, Cheryl T, van Rijn, Rachel D, Rohrer, Susan P, Chicchi, Gary, Underwood, Dennis J, Thornton, Edward R, Smith, Amos B, Hirschmann, Ralph

“…In our continuing program exploring glucose-based peptidomimetics of somatostatin (SRIF-14), we sought to improve the water solubility of our glycosides. This…”
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Bridged androstenediol analogs as ER-β selective SERMs by Blizzard, Timothy A., Gude, Candido, Chan, Wanda, Birzin, Elizabeth T., Mojena, Marina, Tudela, Consuelo, Chen, Fang, Knecht, Kristin, Su, Qin, Kraker, Bryan, Holmes, Mark A., Rohrer, Susan P., Hammond, Milton L.

“…A series of bridged androstenediol derivatives (e.g., 8 and 11) was prepared. The bridged compounds exhibited reduced ER-β selectivity relative to uncyclized…”
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Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs by Tan, Qiang, Blizzard, Timothy A., Morgan, Jerry D., Birzin, Elizabeth T., Chan, Wanda, Yang, Yi Tien, Pai, Lee-Yuh, Hayes, Edward C., DaSilva, Carolyn A., Warrier, Sudha, Yudkovitz, Joel, Wilkinson, Hilary A., Sharma, Nandini, Fitzgerald, Paula M.D., Li, Susan, Colwell, Lawrence, Fisher, John E., Adamski, Sharon, Reszka, Alfred A., Kimmel, Donald, DiNinno, Frank, Rohrer, Susan P., Freedman, Leonard P., Schaeffer, James M., Hammond, Milton L.

“…Chromanes I were discovered as SERAMs (Selective Estrogen Receptor Alpha Modulators) with the potential for the treatment of osteoporosis and cancer. The…”
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Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands by Wildonger, Kenneth J., Ratcliffe, Ronald W., Mosley, Ralph T., Hammond, Milton L., Birzin, Elizabeth T., Rohrer, Susan P.

“…A series of 2-9a bridged tetrahydrofluorenone derivatives were prepared which exhibited significant binding affinity for ERβ and high selectivity for ERβ over…”
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Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists by Parker, Dann L., Meng, Dongfang, Ratcliffe, Ronald W., Wilkening, Robert R., Sperbeck, Donald M., Greenlee, Mark L., Colwell, Lawrence F., Lambert, Sherrie, Birzin, Elizabeth T., Frisch, Katalin, Rohrer, Susan P., Nilsson, Stefan, Thorsell, Ann-Gerd, Hammond, Milton L.

“…Several tetrahydrofluorenones with a triazole fused across C7–C8 showed high levels of ERβ-selectivity and were found to be potent ERβ-agonists. As a class…”
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