Search Results - "ROHRER, S. P"

Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry by Rohrer, Susan P., Birzin, Elizabeth T., Mosley, Ralph T., Berk, Scott C., Hutchins, Steven M., Shen, Dong-Ming, Xiong, Yusheng, Hayes, Edward C., Parmar, Rupa M., Foor, Forrest, Mitra, Sudha W., Degrado, Sylvia J., Shu, Min, Klopp, John M., Cai, Sheng-Jian, Blake, Allan, Wanda W. S. Chan, Pasternak, Alex, Yang, Lihu, Patchett, Arthur A., Smith, Roy G., Chapman, Kevin T., Schaeffer, James M.

“…Nonpeptide agonists of each of the five somatostatin receptors were identified in combinatorial libraries constructed on the basis of molecular modeling of…”
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The discovery of tetrahydrofluorenones as a new class of estrogen receptor β-subtype selective ligands by Wilkening, R.R., Ratcliffe, R.W., Tynebor, E.C., Wildonger, K.J., Fried, A.K., Hammond, M.L., Mosley, R.T., Fitzgerald, P.M.D., Sharma, N., McKeever, B.M., Nilsson, S., Carlquist, M., Thorsell, A., Locco, L., Katz, R., Frisch, K., Birzin, E.T., Wilkinson, H.A., Mitra, S., Cai, S., Hayes, E.C., Schaeffer, J.M., Rohrer, S.P.

“…Synthesis and derivatization of a series of substituted tetrahydrofluorenone analogs giving potent, ERβ subtype-selective ligands are described. Synthesis and…”
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Estrogen receptor β-subtype selective tetrahydrofluorenones: Use of a fused pyrazole as a phenol bioisostere by Wilkening, R.R., Ratcliffe, R.W., Fried, A.K., Meng, D., Sun, W., Colwell, L., Lambert, S., Greenlee, M., Nilsson, S., Thorsell, A., Mojena, M., Tudela, C., Frisch, K., Chan, W., Birzin, E.T., Rohrer, S.P., Hammond, M.L.

“…Synthesis of a series of potent, ERβ selective, fused pyrazole tetrahydrofluorenone analogs is described. Synthesis of a series of fused pyrazole…”
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Distinct effects of the antiestrogen Faslodex on the stability of estrogen receptors-alpha and -beta in the breast cancer cell line MCF-7 by Peekhaus, NT, Chang, T, Hayes, EC, Wilkinson, HA, Mitra, SW, Schaeffer, JM, Rohrer, SP

“…The effects of estrogen receptor (ER) ligands on the stability and transcriptional activity of ERbeta in the breast cancer cell lines MCF-7 and HeLa were…”
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Identification of somatostatin receptors controlling growth hormone and thyrotropin secretion in the chicken using receptor subtype-specific agonists by Geris, KL, de Groef, B, Rohrer, SP, Geelissen, S, Kuhn, ER, Darras, VM

“…Somatostatin (SRIH) functions as an endocrine mediator in processes such as growth, immune resistance and reproduction. Five SRIH receptors (sstr1-5) have been…”
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Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice by Viollet, C., Vaillend, C., Videau, C., Bluet-Pajot, M. T., Ungerer, A., L'héritier, A., Kopp, C., Potier, B., Billard, J. -M., Schaeffer, J., Smith, R. G., Rohrer, S. P., Wilkinson, H., Zheng, H., Epelbaum, J.

“…Somatostatin (SRIF) controls many physiological and pathological processes in the central nervous system but the respective roles of the five receptor isotypes…”
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Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test by Clark, J.A., Alves, S., Gundlah, C., Rocha, B., Birzin, E.T., Cai, S.-J., Flick, R., Hayes, E., Ho, K., Warrier, S., Pai, L., Yudkovitz, J., Fleischer, R., Colwell, L., Li, S., Wilkinson, H., Schaeffer, J., Wilkening, R., Mattingly, E., Hammond, M., Rohrer, S.P.

“…Estrogen acts through two molecularly distinct receptors termed estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) which bind estradiol with…”
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Nonpeptidyl Somatostatin Agonists Demonstrate That sst2 and sst5 Inhibit Stimulated Growth Hormone Secretion from Rat Anterior Pituitary Cells by Parmar, R.M., Chan, W.W.-S., Dashkevicz, M., Hayes, E.C., Rohrer, S.P., Smith, R.G., Schaeffer, J.M., Blake, A.D.

“…Somatostatin (SST) regulates growth hormone (GH) secretion from pituitary somatotrophs by interacting with members of the SST family of G-protein-coupled…”
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Synthesis of a Substance P Antagonist with a Somatostatin Scaffold:  Factors Affecting Agonism/Antagonism at GPCRs and the Role of Pseudosymmetry by Liu, Josephine, Underwood, Dennis J, Cascieri, Margaret A, Rohrer, Susan P, Cantin, Louis-David, Chicchi, Gary, Smith, Amos B, Hirschmann, Ralph

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Organization of minicircle genes for guide RNAs in Trypanosoma brucei by Pollard, V W, Rohrer, S P, Michelotti, E F, Hancock, K, Hajduk, S L

“…We have identified four T. brucei minicircle sequences that are complementary to cytochrome oxidase III (COIII) edited mRNA sequence and have shown the…”
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Ivermectin binding sites in sensitive and resistant Haemonchus contortus by Rohrer, S.P, Birzin, E.T, Eary, C.H, Schaeffer, J.M, Shoops, W.L

“…Membranes from both ivermectin-sensitive and -resistant Haemonchus contortus L3larvae were examined for the presence of high affinity [3H]ivermectin binding…”
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Avermectins and milbemycins against Fasciola hepatica: In vivo drug efficacy and in Vitro receptor binding by Shoop, W.L., Ostlind, D.A., Rohrer, S.P., Mickle, G., Haines, H.W., Michael, B.F., Mrozik, H., Fisher, M.H.

“…Few studies have examined activity against trematedes for the avermectin/milbemycin class of anthelmintics. To gain insight into this, 12 different members of…”
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Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues by ZHIXIONG YE, YINGDUO GAO, LOCCO, L, PARMAR, R. M, CHAN, W. W.-S, SCHAEFFER, J. M, SMITH, R. G, PATCHETT, A. A, NARGUND, R. P, BAKSHI, R. K, CHEN, M.-H, ROHRER, S. P, FEIGHNER, S. D, PONG, S.-S, HOWARD, A. D, BLAKE, A, BIRZIN, E. T

“…Quinazolinone derivatives were synthesized and evaluated as non-peptidic growth hormone secretagogues. Modeling guided design of quinazolinone compound 21 led…”
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Photoaffinity Labeling of Avermectin Binding Sites from Caenorhabditis elegans and Drosophila melanogaster by Rohrer, Susan P., Meinke, Peter T., Hayes, Edward C., Mrozik, Helmut, Schaeffer, James M.

“…An azido-avermectin analog [4"α-(4-azidosalicylamido-ε-caproylamido-β- alanylamido)-4"-deoxyavermectin B1a; azido-AVM] was synthesized and used to…”
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Potent, orally bioavailable somatostatin agonists: Good absorption achieved by urea backbone cyclization by Pasternak, Alexander, Pan, Yanping, Marino, Dominick, Sanderson, Philip E., Mosley, Ralph, Rohrer, Susan P., Birzin, Elizabeth T., Huskey, Su-Er Wu, Jacks, Tom, Schleim, Klaus D, Cheng, Kang, Schaeffer, James M., Patchett, Arthur A., Yang, Lihu

“…Backbone cyclization of urea-based somatostatin agonists resulted in novel, orally bioavailable agonists. Binding assays confirmed that the resulting…”
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Immunoaffinity purification of avermectin-binding proteins from the free-living nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster by Rohrer, S.P, Jacobson, E.B, Hayes, E.C, Birzin, E.T, Schaeffer, J.M

“…Avermectin-binding proteins from the free-living nematode worm Caenorhabditis elegans and from the fruitfly Drosophila melanogaster were purified to…”
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Purification and characterization of phosphoenolpyruvate carboxykinase from the parasitic helminth Ascaris suum by Rohrer, S P, Saz, H J, Nowak, T

“…Phosphoenolpyruvate carboxykinase has been purified from homogenates of Ascaris suum muscle strips to apparent homogeneity as determined by sodium dodecyl…”
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Synthesis and Biological Activities of Potent Peptidomimetics Selective for Somatostatin Receptor Subtype 2 by Yang, Lihu, Berk, Scott C., Rohrer, Susan P., Mosley, Ralph T., Guo, Liangqin, Underwood, Dennis J., Arison, Byron H., Birzin, Elizabeth T., Hayes, Edward C., Mitra, Sudha W., Parmar, Rupa M., Cheng, Kang, Wu, Tsuei-Ju, Butler, Bridgette S., Foor, Forrest, Pasternak, Alexander, Pan, Yanping, Silva, Maria, Freidinger, Roger M., Smith, Roy G., Chapman, Kevin, Schaeffer, James M., Patchett, Arthur A.

“…A series of nonpeptide somatostatin agonists which bind selectively and with high affinity to somatostatin receptor subtype 2 (sst2) have been synthesized. One…”
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Bioreactor cultivation of the nematode Caenorhabditis elegans: large scale production of biologically active drug receptors for pharmaceutical research by Gbewonyo, K, Rohrer, S.P, Buckland, B.C

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Affinity probes for the avermectin binding proteins by Meinke, Peter T, Rohrer, Susan P, Hayes, Edward C, Schaeffer, James M, Fisher, Michael H, Mrozik, Helmut

“…The design and synthesis of a series of avermectin affinity probes used in the identification and purification of the avermectin binding proteins is described…”
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