Search Results - "ROGOZIN, Igor B"

Origin and evolution of spliceosomal introns by Rogozin, Igor B, Carmel, Liran, Csuros, Miklos, Koonin, Eugene V

“…Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing, intensive debate. The introns-early concept, later rebranded…”
Get full text

A detailed history of intron-rich eukaryotic ancestors inferred from a global survey of 100 complete genomes by Csuros, Miklos, Rogozin, Igor B, Koonin, Eugene V

“…Protein-coding genes in eukaryotes are interrupted by introns, but intron densities widely differ between eukaryotic lineages. Vertebrates, some invertebrates…”
Get full text

Editorial: Novel applications of ONT technologies in genomics and transcriptomics by Poliakov, Eugenia, Kaplun, Ludmila, Rogozin, Igor B

Get full text

Exploring background mutational processes to decipher cancer genetic heterogeneity by Goncearenco, Alexander, Rager, Stephanie L, Li, Minghui, Sang, Qing-Xiang, Rogozin, Igor B, Panchenko, Anna R

“…Much remains unknown about the progression and heterogeneity of mutational processes in different cancers and their diagnostic and clinical potential. A…”
Get full text

The 29-nucleotide deletion in SARS-CoV: truncated versions of ORF8 are under purifying selection by Bykova, Anastassia, Saura, Andreu, Glazko, Galina V, Roche-Lima, Abiel, Yurchenko, Vyacheslav, Rogozin, Igor B

“…Accessory proteins have diverse roles in coronavirus pathobiology. One of them in SARS-CoV (the causative agent of the severe acute respiratory syndrome…”
Get full text

Properties and Mechanisms of Deletions, Insertions, and Substitutions in the Evolutionary History of SARS-CoV-2 by Rogozin, Igor B, Saura, Andreu, Poliakov, Eugenia, Bykova, Anastassia, Roche-Lima, Abiel, Pavlov, Youri I, Yurchenko, Vyacheslav

“…SARS-CoV-2 has accumulated many mutations since its emergence in late 2019. Nucleotide substitutions leading to amino acid replacements constitute the primary…”
Get full text

AID and APOBECs as Multifaceted Intrinsic Virus-Restricting Factors: Emerging Concepts in the Light of COVID-19 by Meshcheryakova, Anastasia, Pietschmann, Peter, Zimmermann, Philip, Rogozin, Igor B., Mechtcheriakova, Diana

“…The AID (activation-induced cytidine deaminase)/APOBEC (apolipoprotein B mRNA editing enzyme catalytic subunit) family with its multifaceted mode of action…”
Get full text

Analysis of Stop Codons within Prokaryotic Protein-Coding Genes Suggests Frequent Readthrough Events by Belinky, Frida, Ganguly, Ishan, Poliakov, Eugenia, Yurchenko, Vyacheslav, Rogozin, Igor B

“…Nonsense mutations turn a coding (sense) codon into an in-frame stop codon that is assumed to result in a truncated protein product. Thus, nonsense…”
Get full text

Paraoxonase-1 as a Cardiovascular Biomarker in Caribbean Hispanic Patients Treated with Clopidogrel: Abundance and Functionality by Monero-Paredes, Mariangeli, Santiago, Ednalise, Carrasquillo-Carrion, Kelvin, Renta, Jessicca Y, Rogozin, Igor B, Roche-Lima, Abiel, Duconge, Jorge

“…Clopidogrel, a prescription drug to reduce ischemic events in cardiovascular patients, has been extensively studied in mostly European individuals but not…”
Get full text

Evolution of protein domain promiscuity in eukaryotes by Basu, Malay Kumar, Carmel, Liran, Rogozin, Igor B, Koonin, Eugene V

“…Numerous eukaryotic proteins contain multiple domains. Certain domains show a tendency to occur in diverse domain architectures and can be considered…”
Get full text

Low-Density Lipoprotein Receptor (LDLR) Is Involved in Internalization of Lentiviral Particles Pseudotyped with SARS-CoV-2 Spike Protein in Ocular Cells by Uppal, Sheetal, Postnikova, Olga, Villasmil, Rafael, Rogozin, Igor B, Bocharov, Alexander V, Eggerman, Thomas L, Poliakov, Eugenia, Redmond, T Michael

“…Here, we present evidence that caveolae-mediated endocytosis using LDLR is the pathway for SARS-CoV-2 virus internalization in the ocular cell line ARPE-19…”
Get full text

Crossing fitness valleys via double substitutions within codons by Belinky, Frida, Sela, Itamar, Rogozin, Igor B, Koonin, Eugene V

“…Single nucleotide substitutions in protein-coding genes can be divided into synonymous (S), with little fitness effect, and non-synonymous (N) ones that alter…”
Get full text

No evidence for widespread positive selection on double substitutions within codons in primates and yeasts by Belinky, Frida, Bykova, Anastassia, Yurchenko, Vyacheslav, Rogozin, Igor B.

“…Nucleotide substitutions in protein-coding genes can be divided into synonymous (S) and non-synonymous (N) ones that alter amino acids (including nonsense…”
Get full text

The Functional Consequences of the Novel Ribosomal Pausing Site in SARS-CoV-2 Spike Glycoprotein RNA by Postnikova, Olga A., Uppal, Sheetal, Huang, Weiliang, Kane, Maureen A., Villasmil, Rafael, Rogozin, Igor B., Poliakov, Eugenia, Redmond, T. Michael

“…The SARS-CoV-2 Spike glycoprotein (S protein) acquired a unique new 4 amino acid -PRRA- insertion sequence at amino acid residues (aa) 681–684 that forms a new…”
Get full text

Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase by Pancer, Zeev, Rogozin, Igor B, Iyer, Lakshminarayan M, Liang, Lizhi, Glazko, Galina V, Liston, Victoria G, Pavlov, Youri I, Aravind, L

“…The variable lymphocyte receptors (VLRs) of jawless vertebrates such as lamprey and hagfish are composed of highly diverse modular leucine-rich repeats. Each…”
Get full text

DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors by Ostroverkhova, Daria, Tyryshkin, Kathrin, Beach, Annette K., Moore, Elizabeth A., Masoudi-Sobhanzadeh, Yosef, Barbari, Stephanie R., Rogozin, Igor B., Shaitan, Konstantin V., Panchenko, Anna R., Shcherbakova, Polina V.

“…Alterations in the exonuclease domain of DNA polymerase ε cause ultramutated cancers. These cancers accumulate AGA>ATA transversions; however, their genomic…”
Get full text

Mutational signatures and mutable motifs in cancer genomes by Rogozin, Igor B, Pavlov, Youri I, Goncearenco, Alexander, De, Subhajyoti, Lada, Artem G, Poliakov, Eugenia, Panchenko, Anna R, Cooper, David N

“…Abstract Cancer is a genetic disorder, meaning that a plethora of different mutations, whether somatic or germ line, underlie the etiology of the 'Emperor of…”
Get full text

Phylogenetic analysis of the metazoan carotenoid oxygenase superfamily: a new ancestral gene assemblage of BCO-like (BCOL) proteins by Poliakov, Eugenia, Soucy, Joseph, Gentleman, Susan, Rogozin, Igor B., Redmond, T. Michael

“…Here we describe a new family of carotenoid cleavage oxygenases (CCOs) in metazoans, the BCO2-like (BCOL) clade, which contains lancelet, nematode, and…”
Get full text

Palmitoylation of Metazoan Carotenoid Oxygenases by Uppal, Sheetal, Rogozin, Igor B, Redmond, T Michael, Poliakov, Eugenia

“…Abundant in nature, carotenoids are a class of fat-soluble pigments with a polyene tetraterpenoid structure. They possess antioxidant properties and their…”
Get full text

Dopamine response gene pathways in dorsal striatum MSNs from a gene expression viewpoint: cAMP-mediated gene networks by Babenko, Vladimir N, Galyamina, Anna G, Rogozin, Igor B, Smagin, Dmitry A, Kudryavtseva, Natalia N

“…Medium spiny neurons (MSNs) comprise the main body (95% in mouse) of the dorsal striatum neurons and represent dopaminoceptive GABAergic neurons. The cAMP…”
Get full text