Search Results - "ROGERS, Ophelia"

HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression by Li, Liping, Kim, Jung-Hyun, Lu, Wenyan, Williams, Donna M., Kim, Joseph, Cope, Leslie, Rampal, Raajit K., Koche, Richard P., Xian, Lingling, Luo, Li Z., Vasiljevic, Marija, Matson, Daniel R., Zhao, Zhizhuang Joe, Rogers, Ophelia, Stubbs, Matthew C., Reddy, Karen, Romero, Antonio-Rodriguez, Psaila, Bethan, Spivak, Jerry L., Moliterno, Alison R., Resar, Linda M.S.

“…Myeloproliferative neoplasms (MPNs) transform to myelofibrosis (MF) and highly lethal acute myeloid leukemia (AML), although the actionable mechanisms driving…”
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Ovarian Cancer-associated Ascites Demonstrates Altered Immune Environment: Implications for Antitumor Immunity by GIUNTOLI, Robert L, WEBB, Tonya J, ZOSO, Alessia, ROGERS, Ophelia, DIAZ-MONTES, Teresa P, BRISTOW, Robert E, OELKE, Mathias

“…Background: To identify immunosuppressive elements present in ovarian cancer associated ascites. Patients and Methods: Ascites and plasma were obtained from…”
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Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera by Spivak, Jerry L., Merchant, Akil, Williams, Donna M., Rogers, Ophelia, Zhao, Wanke, Duffield, Amy, Resar, Linda S., Moliterno, Alison R., Zhao, Zhizhuang J.

“…The myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis and primary myelofibrosis are hematopoietic stem cell disorders and share driver…”
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Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: analysis of molecular genetics and clinical phenotypes by STEIN, Brady L, WILLIAMS, Donna M, O'KEEFE, Christine, ROGERS, Ophelia, INGERSOLL, Roxann G, SPIVAK, Jerry L, VERMA, Amit, MACIEJEWSKI, Jarek P, MCDEVITT, Michael A

“…The myeloproliferative neoplasms, essential thrombocytosis, polycythemia vera and primary myelofibrosis, share the same acquired genetic lesion, but the…”
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Molecular mimicry in the chronic myeloproliferative disorders: reciprocity between quantitative JAK2 V617F and Mpl expression by Moliterno, Alison R., Williams, Donna M., Rogers, Ophelia, Spivak, Jerry L.

“…An activating JAK2 mutation (JAK2 V617F) is present in the chronic myeloproliferative disorders (MPDs), polycythemia vera (PV), idiopathic myelofibrosis (IMF),…”
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Disease burden at the progenitor level is a feature of primary myelofibrosis: a multivariable analysis of 164 JAK2 V617F-positive myeloproliferative neoplasm patients by Stein, Brady L, Williams, Donna M, Rogers, Ophelia, Isaacs, Mary Ann, Spivak, Jerry L, Moliterno, Alison R

“…Objective Suppression of normal hematopoiesis by the neoplastic clone (clonal dominance) is a feature of the myeloproliferative neoplasms, but the determinants…”
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Single Cell Analysis Of JAK2V617F Positive MPN Stem/Progenitor Cells In Chronic Phase and Leukemic Transformation by Gerber, Jonathan M., Williams, Donna M., Rogers, Ophelia, Morse, Sarah, Zhang, Hao, McDevitt, Michael A, Jones, Richard J., Spivak, Jerry L., Moliterno, Alison R.

“…Essential thrombocytosis (ET), polycythemia vera (PV), and myelofibrosis (MF) share the JAK2V617F mutation, but differ with regard to clinical phenotype, rate…”
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Ascites Specific Inhibition of CD1d-Mediated Activation of Natural Killer T Cells by WEBB, Tonya J, GIUNTOLI, Robert L, ROGERS, Ophelia, SCHNECK, Jonathan, OELKE, Mathias

“…Purpose: Natural killer T (NKT) cells recognize lipid antigen presented by CD1 molecules. NKT cells can both directly, through cytotoxicity, and indirectly,…”
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Sex differences in the JAK2V617F allele burden in chronic myeloproliferative disorders by STERN, Brady L, WILLIAMS, Donna M, WANG, Nae-Yuh, ROGERS, Ophelia, ISAACS, Mary Ann, PEMMARAJU, Naveen, SPIVAK, Jerry L, MOLITERNO, Alison R

“…Background The JAK2V617F allele burden is a variable measure, determined by the frequency of mitotic recombination events and the expansion of JAK2V617F…”
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A c- MPL Splice Variant up-Regulated in Myeloproliferative Neoplasms Modulates Thrombopoietin Signaling and Induces Cycling of Hematopoietic Stem Cells and Inflammatory Progenitors by Resar, Linda, Thompson, Zanshe, Luo, Li Z, Williams, Donna Marie, Li, Liping, Cope, Leslie, Herrera, Iliana, Rogers, Ophelia, Moliterno, Alison R., Spivak, Jerry L.

“…Introduction: Myeloproliferative neoplasms (MPN) are clonal disorders caused by mutations that activate JAK/STAT signaling through the thrombopoietin receptor,…”
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High Mobility Group A1 Chromatin Regulators: Key Epigenetic Switches and Therapeutic Targets Required for Leukemic Transformation in JAK2 Mutant MPN by Li, Liping, Lu, Wenyan, Moliterno, Alison R., Xian, Lingling, Kim, Joseph, Rogers, Ophelia, Spivak, Jerry L., Resar, Linda

“…Introduction: Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell (HSC) disorders characterized by hyperactive JAK/STAT signaling and…”
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Thrombopoietin is required for full phenotype expression in a JAK2.sup.V617F transgenic mouse model of polycythemia vera by Spivak, Jerry L, Merchant, Akil, Williams, Donna M, Rogers, Ophelia, Zhao, Wanke, Duffield, Amy, Resar, Linda S, Moliterno, Alison R, Zhao, Zhizhuang J

“…The myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis and primary myelofibrosis are hematopoietic stem cell disorders and share driver…”
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Abstract 2765: The indoleamine 2,3 dioxygenase-1 pathway drives intratumoral B cell maintenance by Johnson, Burles Avner, Aragaki, Adam K., Williams, Donna M., Rogers, Ophelia, Luo, Li, Xian, Lingling, Chia, Lionel, Hahn, Noah M., Desiderio, Stephen, Johnson, Theodore S., McConkey, David J., Resar, Linda M.S.

“…Immunotherapy has revolutionized cancer treatment by improving survival in many cancer subtypes. While tumor infiltrating B (TIL-B) cells correlate with…”
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Abstract 2666: HMGA1: An epigenetic switch required for MPN progression by inducing GATA-2 and cell cycle progression through enhancer rewiring by Li, Liping, Kim, Jung-Hyun, Lu, Wenyan, Williams, Donna Marie, Xian, Lingling, Kim, Joseph, Rogers, Ophelia, Rampal, Raajit K., Koche, Richard P., Cope, Leslie, Reddy, Karen, Matson, Daniel R., Zhao, Joe, Spivak, Jerry L., Moliterno, Alison R., Resar, Linda

“…Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell (HSC) disorders characterized by hyperactive JAK/STAT signaling and increased risk of…”
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The High Mobility Group A1 Chromatin Regulator Is Required for Pathologic Megakaryocyte Development and Progression to Myelofibrosis in JAK2V617F Murine Models by Moliterno, Alison R., Williams, Donna Marie, Li, Liping, Xian, Lingling, Luo, Li, Duffield, Amy S., Rogers, Ophelia, Spivak, Jerry L., Resar, Linda

“…Introduction:JAK2V617F-positive myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell (HSC) disorders characterized by unregulated JAK2/STAT…”
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HMGA1 Chromatin Regulators Drive Progression in Myeloproliferative Neoplasms through Epigenetic Rewiring to Induce Networks Involved in GATA2 and Proliferation by Li, Liping, Kim, Jung-Hyun, Lu, Wenyan, Cope, Leslie, Williams, Donna M, Kim, Joseph, Rampal, Raajit, Koche, Richard, Xian, Lingling, Luo, Li, Vasiljevic, Marija, Matson, Daniel R, Zhao, Zhizhuang Joe, Rogers, Ophelia, Stubbs, Matthew C., Reddy, Karen, Spivak, Jerry L., Moliterno, Alison R., Resar, Linda

“…Introduction: Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell (HSC) disorders characterized by hyperactive JAK/STAT signaling and…”
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Mechanism of Escape from LNK Negative Regulation: Constitutively Active JAK2V617F Retains Lysine63-Ubiquitin by Patterson-Fortin, Jeffrey, Spivak, Jerry L., Duffield, Amy S., Williams, Donna Marie, Rogers, Ophelia, Zhao, Zhizhuang Joe, Moliterno, Alison R.

“…Introduction The myeloproliferative neoplasms (MPN), polycythemia vera (PV), essential thrombocytosis and primary myelofibrosis are clonal hematopoietic stem…”
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High Mobility Group A1 Chromatin Remodeling Proteins: Potential Therapeutic Targets Involved in Polycythemia Vera Transformation to Acute Leukemia in Humans and JAK2 V617F Transgenic Mouse Models by Resar, Linda, Williams, Donna Marie, Xian, Lingling, Zhao, Zhizhuang Joe, Rogers, Ophelia, Spivak, Jerry L., Moliterno, Alison R.

“…Introduction: Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell (HSC) disorders characterized by overproduction of mature blood cells and…”
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High Mobility Group A1 Chromatin Remodeling Proteins Amplify Inflammatory Networks to Drive Leukemic Transformation in Chronic Myeloproliferative Neoplasia in Humans and JAK2V617F Transgenic Mouse Models by Resar, Linda, Williams, Donna Marie, Xian, Lingling, Lu, Wenyan, Chisholm, Briyana, Luo, Li, Zhao, Zhizhuang Joe, Rogers, Ophelia, Spivak, Jerry L., Moliterno, Alison R.

“…Introduction: Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell (HSC) disorders characterized by overproduction of mature blood cells and…”
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Independent Association of Male Sex with Presentation and Clinical Outcomes in Myeloproliferative Neoplasms by Karantanos, Theodoros, Chaturvedi, Shruti, Spivak, Jerry L., Resar, Linda, Braunstein, Evan M, Karanika, Styliani, Williams, Donna Marie, Rogers, Ophelia, Moliterno, Alison R.

“…INTRODUCTION: The chronic MPN, essential thrombocytosis (ET), polycythemia vera (PV) and primary myelofibrosis (PMF), share mutations of JAK2, MPL and CALR,…”
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