Search Results - "ROGERS, James A"

Mechanisms of lysophosphatidylcholine‐induced demyelination: A primary lipid disrupting myelinopathy by Plemel, Jason R., Michaels, Nathan J., Weishaupt, Nina, Caprariello, Andrew V., Keough, Michael B., Rogers, James A., Yukseloglu, Aran, Lim, Jaehyun, Patel, Vikas V., Rawji, Khalil S., Jensen, Samuel K., Teo, Wulin, Heyne, Belinda, Whitehead, Shawn N., Stys, Peter K., Yong, V. Wee

“…For decades lysophosphatidylcholine (LPC, lysolecithin) has been used to induce demyelination, without a clear understanding of its mechanisms. LPC is an…”
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An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination by Keough, Michael B., Rogers, James A., Zhang, Ping, Jensen, Samuel K., Stephenson, Erin L., Chen, Tieyu, Hurlbert, Mitchel G., Lau, Lorraine W., Rawji, Khalil S., Plemel, Jason R., Koch, Marcus, Ling, Chang-Chun, Yong, V. Wee

“…Remyelination is the generation of new myelin sheaths after injury facilitated by processes of differentiating oligodendrocyte precursor cells (OPCs). Although…”
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An introduction to causal inference for pharmacometricians by Rogers, James A., Maas, Hugo, Pitarch, Alejandro Pérez

“…As formal causal inference begins to play a greater role in disciplines that intersect with pharmacometrics, such as biostatistics, epidemiology, and…”
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Confounded exposure metrics by Wiens, Matthew R., French, Jonathan L., Rogers, James A.

“…[...]in an analysis of cabozantinib, dose modifications throughout the trial justified the use of CavgTE in a survival analysis to show E-R relationship for…”
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Causa Nostra: The Potentially Legitimate Business of Drawing Causal Inferences From Observational Data by Rogers, James A.

“…(In this simple example, resampling is equivalent to parametric Bernoulli sampling, but the intention here is to hew as closely as possible to a typical…”
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Gray Matter Hypoxia in the Brain of the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis by Johnson, Thomas W, Wu, Ying, Nathoo, Nabeela, Rogers, James A, Wee Yong, V, Dunn, Jeff F

“…Multiple sclerosis (MS) has a significant inflammatory component and may have significant gray matter (GM) pathophysiology. Brain oxygenation is a sensitive…”
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Fit-for-purpose method development and validation for successful biomarker measurement by LEE, Jean W, DEVANARAYAN, Viswanath, ROGERS, James A, MILLHAM, Robert, O'BRIEN, Peter J, SAILSTAD, Jeff, KHAN, Masood, RAY, Chad, WAGNER, John A, BARRETT, Yu Chen, WEINER, Russell, ALLINSON, John, FOUNTAIN, Scott, KELLER, Stephen, WEINRYB, Ira, GREEN, Marie, DUAN, Larry

“…Despite major advances in modern drug discovery and development, the number of new drug approvals has not kept pace with the increased cost of their…”
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Covariate modeling in pharmacometrics: General points for consideration by Sanghavi, Kinjal, Ribbing, Jakob, Rogers, James A., Ahmed, Mariam A., Karlsson, Mats O., Holford, Nick, Chasseloup, Estelle, Ahamadi, Malidi, Kowalski, Kenneth G., Cole, Susan, Kerwash, Essam, Wade, Janet R., Liu, Chao, Wang, Yaning, Trame, Mirjam N., Zhu, Hao, Wilkins, Justin J.

“…Modeling the relationships between covariates and pharmacometric model parameters is a central feature of pharmacometric analyses. The information obtained…”
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Detecting deoxyhemoglobin in spinal cord vasculature of the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis using susceptibility MRI and hyperoxygenation by Nathoo, Nabeela, Rogers, James A, Yong, V Wee, Dunn, Jeff F

“…Susceptibility-weighted imaging (SWI) detects hypointensities due to iron deposition and deoxyhemoglobin. Previously it was shown that SWI detects…”
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Review: Endocrine disrupting chemicals and immune responses: A focus on bisphenol-A and its potential mechanisms by Rogers, James A., Metz, Luanne, Yong, V. Wee

“…► Exposure to endocrine disrupting chemicals, specifically Bisphenol-A, is common. ► Bisphenol-A produces several effects on various immune cell types. ►…”
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Biochemically altered myelin triggers autoimmune demyelination by Caprariello, Andrew V., Rogers, James A., Morgan, Megan L., Hoghooghi, Vahid, Plemel, Jason R., Koebel, Adam, Tsutsui, Shigeki, Dunn, Jeffrey F., Kotra, Lakshmi P., Ousman, Shalina S., Yong, V. Wee, Stys, Peter K.

“…Although immune attack against central nervous system (CNS) myelin is a central feature of multiple sclerosis (MS), its root cause is unresolved. In this…”
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Central nervous system targeted autoimmunity causes regional atrophy: a 9.4T MRI study of the EAE mouse model of Multiple Sclerosis by Hamilton, A. Max, Forkert, Nils D., Yang, Runze, Wu, Ying, Rogers, James A., Yong, V. Wee, Dunn, Jeff F.

“…Atrophy has become a clinically relevant marker of progressive neurodegeneration in multiple sclerosis (MS). To better understand atrophy, mouse models that…”
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Gestational bisphenol-A exposure lowers the threshold for autoimmunity in a model of multiple sclerosis by Rogers, James A., Mishra, Manoj K., Hahn, Jennifer, Greene, Catherine J., Yates, Robin M., Metz, Luanne M., Yong, V. Wee

“…Environmental and hormonal factors are implicated in dysimmunity in multiple sclerosis. We investigated whether bisphenol-A, a prominent contaminant with…”
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Combining patient-level and summary-level data for Alzheimer’s disease modeling and simulation: a beta regression meta-analysis by Rogers, James A., Polhamus, Daniel, Gillespie, William R., Ito, Kaori, Romero, Klaus, Qiu, Ruolun, Stephenson, Diane, Gastonguay, Marc R., Corrigan, Brian

“…Our objective was to develop a beta regression (BR) model to describe the longitudinal progression of the 11 item Alzheimer’s disease (AD) assessment scale…”
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Susceptibility weighted imaging detects prominent veins that precede or coincide with maximal motor disability in a model of multiple sclerosis: A pilot study by Nathoo, Nabeela, Wu, Ying, Rogers, James A., Yong, V. Wee, Dunn, Jeff F.

“…•SWI MRI detects prominent veins in EAE at times related to perivascular cuffs.•SWI hypointensities are present before any overt motor dysfunction in EAE.•The…”
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The Effects of Bisphenol-A on the Immune System of Wild Yellow Perch, Perca flavescens by Rogers, James A., Mirza, Reehan S.

“…Bisphenol-A (BPA) is an environmental contaminant used in the manufacturing of polycarbonate plastics and epoxy resins, which has been discovered in freshwater…”
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Quantitative disease progression model of α‐1 proteinase inhibitor therapy on computed tomography lung density in patients with α‐1 antitrypsin deficiency by Tortorici, Michael A., Rogers, James A., Vit, Oliver, Bexon, Martin, Sandhaus, Robert A., Burdon, Jonathan, Chorostowska‐Wynimko, Joanna, Thompson, Philip, Stocks, James, McElvaney, Noel G., Chapman, Kenneth R., Edelman, Jonathan M.

“…Aims Early‐onset emphysema attributed to α‐1 antitrypsin deficiency (AATD) is frequently overlooked and undertreated. RAPID‐RCT/RAPID‐OLE, the largest clinical…”
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Liposomal Formulations of Synthetic MUC1 Peptides:  Effects of Encapsulation versus Surface Display of Peptides on Immune Responses by Guan, Holly H, Budzynski, Wladyslaw, Koganty, R. Rao, Krantz, Mark J, Reddish, Mark A, Rogers, James A, Longenecker, B. Michael, Samuel, John

“…Synthetic human MUC1 peptides are important candidates for therapeutic cancer vaccines. To explore whether a human MUC1 peptide BP25…”
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Upper Limb Intention Tremor in Multiple Sclerosis: An Evidence-Based Review of Assessment and Treatment by McCreary, J Keiko, Rogers, James A, Forwell, Susan J

“…To present the current knowledge on the characteristics, assessment, and treatment of upper limb intention tremor to inform and improve future intervention…”
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Peripheral blood B cells producing donor-specific HLA antibodies in vitro by Han, Mei, Rogers, James A, Lavingia, Bhavna, Stastny, Peter

“…Abstract Donor-specific HLA antibodies have been associated with acute and chronic rejection. Such antibodies may sometimes not be detected in recipient serum…”
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