Search Results - "ROEWER, NORBERT"

Hypoxia-Induced MicroRNA-212/132 Alter Blood-Brain Barrier Integrity Through Inhibition of Tight Junction-Associated Proteins in Human and Mouse Brain Microvascular Endothelial Cells by Burek, Malgorzata, König, Anna, Lang, Mareike, Fiedler, Jan, Oerter, Sabrina, Roewer, Norbert, Bohnert, Michael, Thal, Serge C., Blecharz-Lang, Kinga G., Woitzik, Johannes, Thum, Thomas, Förster, Carola Y.

“…Blood-brain barrier (BBB) integrity is one of the important elements of central nervous system (CNS) homeostasis. MicroRNAs (miRs) have been demonstrated to…”
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Multiple protocadherins are expressed in brain microvascular endothelial cells and might play a role in tight junction protein regulation by Dilling, Christina, Roewer, Norbert, Förster, Carola Y, Burek, Malgorzata

“…Protocadherins (Pcdhs) are a large family of cadherin-related molecules. They play a role in cell adhesion, cellular interactions, and development of the…”
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Evaluation of the potential toxicity of unmodified and modified cyclodextrins on murine blood-brain barrier endothelial cells by Shityakov, Sergey, Salmas, Ramin Ekhteiari, Salvador, Ellaine, Roewer, Norbert, Broscheit, Jens, Förster, Carola

“…In this study, we investigated the cytotoxic effects of unmodified α-cyclodextrin (α-CD) and modified cyclodextrins, including trimethyl-β-cyclodextrin…”
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Comparison of volatile anesthetic-induced preconditioning in cardiac and cerebral system: molecular mechanisms and clinical aspects by Chen, Shasha, Lotz, Christopher, Roewer, Norbert, Broscheit, Jens-Albert

“…Volatile anesthetic-induced preconditioning (APC) has shown to have cardiac and cerebral protective properties in both pre-clinical models and clinical trials…”
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A Factorial Trial of Six Interventions for the Prevention of Postoperative Nausea and Vomiting by Apfel, Christian C, Korttila, Kari, Abdalla, Mona, Kerger, Heinz, Turan, Alparslan, Vedder, Ina, Zernak, Carmen, Danner, Klaus, Jokela, Ritva, Pocock, Stuart J, Trenkler, Stefan, Kredel, Markus, Biedler, Andreas, Sessler, Daniel I, Roewer, Norbert

“…In this factorial trial, the prophylactic use of dexamethasone, droperidol, ondansetron, and total intravenous anesthesia each resulted in similar reductions…”
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Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model by Curtaz, Carolin J, Schmitt, Constanze, Herbert, Saskia-Laureen, Feldheim, Jonas, Schlegel, Nicolas, Gosselet, Fabien, Hagemann, Carsten, Roewer, Norbert, Meybohm, Patrick, Wöckel, Achim, Burek, Malgorzata

“…The most threatening metastases in breast cancer are brain metastases, which correlate with a very poor overall survival, but also a limited quality of life. A…”
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Claudin-5 as a Novel Estrogen Target in Vascular Endothelium by Burek, Malgorzata, Arias-Loza, Paula A, Roewer, Norbert, Förster, Carola Y

“…OBJECTIVE—Estrogens have multiple effects on vascular physiology and function. In the present study, we look for direct estrogen target genes within junctional…”
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The connection of monocytes and reactive oxygen species in pain by Hackel, Dagmar, Pflücke, Diana, Neumann, Annick, Viebahn, Johannes, Mousa, Shaaban, Wischmeyer, Erhard, Roewer, Norbert, Brack, Alexander, Rittner, Heike Lydia

“…The interplay of specific leukocyte subpopulations, resident cells and proalgesic mediators results in pain in inflammation. Proalgesic mediators like reactive…”
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Toll like Receptor (TLR)-4 as a Regulator of Peripheral Endogenous Opioid-Mediated Analgesia in Inflammation by Sauer, Reine-Solange, Hackel, Dagmar, Morschel, Laura, Sahlbach, Henrike, Wang, Ying, Mousa, Shaaban A, Roewer, Norbert, Brack, Alexander, Rittner, Heike L

“…Background: Leukocytes containing opioid peptides locally control inflammatory pain. In the early phase of complete Freund's adjuvant (CFA)-induced hind paw…”
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Kidney Ischemia/Reperfusion Injury Induces Changes in the Drug Transporter Expression at the Blood–Brain Barrier in vivo and in vitro by Burek, Malgorzata, Burmester, Sandra, Salvador, Ellaine, Möller-Ehrlich, Kerstin, Schneider, Reinhard, Roewer, Norbert, Nagai, Michiaki, Förster, Carola Y.

“…Ischemia/reperfusion injury is a major cause of acute kidney injury (AKI). AKI is characterized by a sudden decrease in kidney function, systemic inflammation,…”
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Phosphodiesterase‐4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation by Schick, Martin Alexander, Wunder, Christian, Wollborn, Jakob, Roewer, Norbert, Waschke, Jens, Germer, Christoph‐Thomas, Schlegel, Nicolas

“…Key points •  A specific therapy to treat capillary leakage in systemic inflammation and sepsis is not available at present. •  Recent studies demonstrated…”
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Sevoflurane-Sulfobutylether-β-Cyclodextrin Complex: Preparation, Characterization, Cellular Toxicity, Molecular Modeling and Blood-Brain Barrier Transport Studies by Shityakov, Sergey, Puskás, István, Pápai, Katalin, Salvador, Ellaine, Roewer, Norbert, Förster, Carola, Broscheit, Jens-Albert

“…The objective of the present investigation was to study the ability of sulfobutylether-β-cyclodextrin (SBEβCD) to form an inclusion complex with sevoflurane…”
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In Silico Modeling of Indigo and Tyrian Purple Single-Electron Nano-Transistors Using Density Functional Theory Approach by Shityakov, Sergey, Roewer, Norbert, Förster, Carola, Broscheit, Jens-Albert

“…The purpose of this study was to develop and implement an in silico model of indigoid-based single-electron transistor (SET) nanodevices, which consist of…”
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Microdialysis and ultrasound elastography for monitoring of localized muscular reaction after pharmacological stimulation in rats by Johannsen, Stephan, Schick, Martin, Roewer, Norbert, Schuster, Frank

“…Halothane and caffeine are known to cause skeletal muscular contractions in vitro and have been proven to induce circumscribed metabolic reactions when…”
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Aromatase inhibition attenuates desflurane-induced preconditioning against acute myocardial infarction in male mouse heart in vivo by Jazbutyte, Virginija, Stumpner, Jan, Redel, Andreas, Lorenzen, Johan M, Roewer, Norbert, Thum, Thomas, Kehl, Franz

“…The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. We…”
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Ionization states, cellular toxicity and molecular modeling studies of midazolam complexed with trimethyl-β-cyclodextrin by Shityakov, Sergey, Sohajda, Tamás, Puskás, István, Roewer, Norbert, Förster, Carola, Broscheit, Jens-Albert

“…We investigated the ionization profiles for open-ring (OR) and closed-ring (CR) forms of midazolam and drug-binding modes with…”
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Phosphodiesterase 4 Inhibition Dose Dependently Stabilizes Microvascular Barrier Functions and Microcirculation in a Rodent Model of Polymicrobial Sepsis by Flemming, Sven, Schlegel, Nicolas, Wunder, Christian, Meir, Michael, Baar, Wolfgang, Wollborn, Jakob, Roewer, Norbert, Germer, Christoph-Thomas, Schick, Martin Alexander

“…ABSTRACTBackgroundBreakdown of microvascular endothelial barrier functions contributes to disturbed microcirculation, organ failure, and death in sepsis…”
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Balanced Hydroxyethylstarch (HES 130/0.4) Impairs Kidney Function In-Vivo without Inflammation by Schick, Martin Alexander, Baar, Wolfgang, Bruno, Raphael Romano, Wollborn, Jakob, Held, Christopher, Schneider, Reinhard, Flemming, Sven, Schlegel, Nicolas, Roewer, Norbert, Neuhaus, Winfried, Wunder, Christian

“…Volume therapy is a standard procedure in daily perioperative care, and there is an ongoing discussion about the benefits of colloid resuscitation with…”
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In vitro effects of levosimendan on muscle of malignant hyperthermia susceptible and non-susceptible swine by Schuster, Frank, Johannsen, Stephan, Isbary, Susanne, Türkmeneli, Ismail, Roewer, Norbert

“…The calcium sensitizer levosimendan is increasingly used to improve hemodynamics in patients with acutely decompensated heart failure. By binding to cardiac…”
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Perioperative redistribution of regional ventilation and pulmonary function: a prospective observational study in two cohorts of patients at risk for postoperative pulmonary complications by Bauer, Maria, Opitz, Anne, Filser, Jörg, Jansen, Hendrik, Meffert, Rainer H, Germer, Christoph T, Roewer, Norbert, Muellenbach, Ralf M, Kredel, Markus

“…Postoperative pulmonary complications (PPCs) increase morbidity and mortality of surgical patients, duration of hospital stay and costs. Postoperative…”
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