Search Results - "RODRIGUES, CARLOS R."

Sodium montmorillonite/amine-containing drugs complexes: new insights on intercalated drugs arrangement into layered carrier material by Bello, Murilo L, Junior, Aridio M, Vieira, Bárbara A, Dias, Luiza R S, de Sousa, Valéria P, Castro, Helena C, Rodrigues, Carlos R, Cabral, Lucio M

“…Layered drug delivery carriers are current targets of nanotechnology studies since they are able to accommodate pharmacologically active substances and are…”
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Antiviral Drug Discovery and Development for Mayaro Fever - What do we have so far? by Mello, Marcos V P, Domingos, Thaisa F S, Ferreira, Davis F, Ribeiro, Mariana M J, Ribeiro, Thayssa P, Rodrigues, Carlos R, Souza, Alessandra M T

“…Tropical infectious diseases cause millions of deaths every year in developing countries, with about half of the world population living at risk. Mayaro virus…”
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Synthesis, tuberculosis inhibitory activity, and SAR study of N-substituted-phenyl-1,2,3-triazole derivatives by Costa, Marilia S., Boechat, Núbia, Rangel, Érica A., da Silva, Fernando de C., de Souza, Alessandra M.T., Rodrigues, Carlos R., Castro, Helena C., Junior, Ivan N., Lourenço, Maria Cristina S., Wardell, Solange M.S.V., Ferreira, Vitor F.

“…Tuberculosis (TB) is caused by Mycobacterium tuberculosis and remains as a leading cause of mortality worldwide. The in vitro anti-tuberculosis screening of…”
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Toxicological assessment of SGLT2 inhibitors metabolites using in silico approach by JESUS, JÉSSICA B. DE, CONCEIÇÃO, RAISSA A. DA, MACHADO, THAYNÁ R., BARBOSA, MARIA L.C., DOMINGOS, THAISA F.S., CABRAL, LUCIO M., RODRIGUES, CARLOS R., ABRAHIM-VIEIRA, BÁRBARA, SOUZA, ALESSANDRA M.T. DE

“…Abstract Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are the latest class of drugs approved to treat type 2 DM (T2DM). Although adverse effects are…”
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Development of a validation protocol method for nucleic acid testing to detect human immunodeficiency virus, hepatitis C virus, and hepatitis B virus by Silva, Marcele C C DA, Abreu, Letícia C L DE, Carmo, Flavia A DO, Rodrigues, Carlos R, Sousa, Valeria P DE, Cabral, Lucio M

“…The concern about the risks of viral infections transmission through blood transfusion has led into a search for improvements on screening tests used for the…”
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Synthesis, antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides by JORDAO, Alessandro K, FERREIRA, Vitor F, LIMA, Emerson S, DE SOUZA, Maria C. B. V, CARLOS, Eduardo C. L, CASTRO, Helena C, GERALDO, Reinaldo B, RODRIGUES, Carlos R, ALMEIDA, Maria C. B, CUNHA, Anna C

“…This paper describes the synthesis, antiplatelet and theoretical evaluations of 10 N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides…”
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Intestinal uptake of insulin nanoparticles: facts or myths? by Lopes, Marlene A, Abrahim, Bárbara A, Seiça, Raquel, Veiga, Francisco, Rodrigues, Carlos R, Ribeiro, António J

“…The oral route is the most suitable and physiological delivery route. Oral insulin delivery would minimize the health hazard implied in repeated injection,…”
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In Silico studies of novel Sildenafil self-emulsifying drug delivery system absorption improvement for pulmonary arterial hypertension by ABRAHIM-VIEIRA, BARBÁRA A., SOUZA, ALESSANDRA M.T. DE, BARROS, RITA C., CARMO, FLÁVIA A. DO, ABREU, LETÍCIA C.L. DE, MOREIRA, RONYSON S.S., HONÓRIO, THIAGO S., RODRIGUES, CARLOS R., SOUSA, VALERIA P. DE, CABRAL, LUCIO M.

“…Abstract Sildenafil is a potent selective inhibitor of phosphosdiesterase-5 previously used in erectile dysfunction and subsequently approved in 2005 for…”
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Titanium dioxide-montmorillonite nanocomposite as photoprotective agent against ultraviolet B radiation-induced mutagenesis in Saccharomyces cerevisiae: a potential candidate for safer sunscreens by Paiva, Juliana P, Santos, Bianca A M C, Kibwila, Daniel M, Gonçalves, Tula C W, Pinto, A Viviana, Rodrigues, Carlos R, Leitão, Alvaro C, Cabral, Lúcio M, De Pádula, Marcelo

“…Photoprotective potential and biological consequences (mutagenic potential) of octyl-dimethyl-PABA (ODP), titanium dioxide (TiO2 ), and montmorillonite (MMT)…”
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Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors by Gonzaga, Daniel T G, Oliveira, Felipe H, von Ranke, N L, Pinho, G Q, Salles, Juliana P, Bello, Murilo L, Rodrigues, Carlos R, Castro, Helena C, de Souza, Hellen V C M, Reis, Caroline R C, Leme, Rennan P P, Mafra, João C M, Pinheiro, Luiz C S, Hoelz, Lucas V B, Boechat, Nubia, Faria, Robson X

“…Twenty new 2-(1 -pyrazol-1-yl)-1,3,4-thiadiazole analogs were synthetized to develop P2X7 receptor (P2X7R) inhibitors. P2X7R inhibition was evaluated in mouse…”
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Synthesis, antichagasic in vitro evaluation, cytotoxicity assays, molecular modeling and SAR/QSAR studies of a 2-phenyl-3-(1-phenyl-1 H-pyrazol-4-yl)-acrylic acid benzylidene-carbohydrazide series by Vera-DiVaio, Maria A.F., Freitas, Antônio C.C., Castro, Helena C., de Albuquerque, Sérgio, Cabral, Lucio M., Rodrigues, Carlos R., Albuquerque, Magaly G., Martins, Rita C.A., Henriques, Maria G.M.O., Dias, Luiza R.S.

“…The 6k (X = H, Y = NO 2, pIC 50 = 4.55 M) and 6l (X = F, Y = CN, pIC 50 = 4.27 M) are the most potent trypanocidal agents. However, 6l showed the most…”
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4-(1H-Pyrazol-1-yl) benzenesulfonamide derivatives: identifying new active antileishmanial structures for use against a neglected disease by Marra, Roberta K F, Bernardino, Alice M R, Proux, Tathiane A, Charret, Karen S, Lira, Marie-Luce F, Castro, Helena C, Souza, Alessandra M T, Oliveira, Cesar D, Borges, Júlio C, Rodrigues, Carlos R, Canto-Cavalheiro, Marilene M, Leon, Leonor L, Amaral, Veronica F

“…Leishmaniasis is a neglected disease responsible for about 56,000 deaths every year. Despite its importance, there are no effective, safe and proper treatments…”
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Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series by Dias, Luiza R S, Santos, Marcelo B, Albuquerque, Sérgio de, Castro, Helena C, de Souza, Alessandra M T, Freitas, Antônio C C, DiVaio, Maria A V, Cabral, Lucio M, Rodrigues, Carlos R

“…The development of new drugs against Trypanosoma cruzi is still required since the only two drugs currently used cause severe side effects. In this work we…”
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Asymmetric bioreduction of β-ketoesters derivatives by Kluyveromyces marxianus: influence of molecular structure on the conversion and enantiomeric excess by Oliveira, Simone S S, Bello, Murilo L, Rodrigues, Carlos R, Azevedo, Paula L DE, Ramos, Maria C K V, Aquino-Neto, Francisco R DE, Fiaux, Sorele B, Dias, Luiza R S

“…This study presents the bioreduction of six β-ketoesters by whole cells of Kluyveromyces marxianus and molecular investigation of a series of 13 β-ketoesters…”
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Computational Studies of Benzoxazinone Derivatives as Antiviral Agents against Herpes Virus Type 1 Protease by Mello, Juliana F R, Botelho, Nathália C, Souza, Alessandra M T, Oliveira, Riethe, Brito, Monique A, Abrahim-Vieira, Bárbara de A, Sodero, Ana Carolina R, Castro, Helena C, Cabral, Lucio M, Miceli, Leonardo A, Rodrigues, Carlos R

“…Herpes simplex virus infections have been described in the medical literature for centuries, yet the the drugs available nowadays for therapy are largely…”
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Design, Synthesis, and Pharmacological Profile of Novel Fused Pyrazolo[4,3-d]pyridine and Pyrazolo[3,4-b][1,8]naphthyridine Isosteres:  A New Class of Potent and Selective Acetylcholinesterase Inhibitors by Barreiro, Eliezer J, Camara, Celso A, Verli, Hugo, Brazil-Más, Leonora, Castro, Newton G, Cintra, Wagner M, Aracava, Yasco, Rodrigues, Carlos R, Fraga, Carlos A. M

“…A new family of tacrine (THA) analogues (7−9, 12), containing the azaheterocyclic pyrazolo[4,3-d]pyridine or pyrazolo[3,4-b][1,8]naphthyridine systems as…”
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Molecular docking studies of marine diterpenes as inhibitors of wild-type and mutants HIV-1 reverse transcriptase by Miceli, Leonardo A, Teixeira, Valéria L, Castro, Helena C, Rodrigues, Carlos R, Mello, Juliana F R, Albuquerque, Magaly G, Cabral, Lucio M, de Brito, Monique A, de Souza, Alessandra M T

“…AIDS is a pandemic responsible for more than 35 million deaths. The emergence of resistant mutations due to drug use is the biggest cause of treatment failure…”
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Synthesis, antiviral activity and molecular modeling of oxoquinoline derivatives by Santos, Fernanda da C., Abreu, Paula, Castro, Helena C., Paixão, Izabel C.P.P., Cirne-Santos, Claudio C., Giongo, Viveca, Barbosa, Juliana E., Simonetti, Bruno R., Garrido, Valéria, Bou-Habib, Dumith Chequer, Silva, David de O., Batalha, Pedro N., Temerozo, Jairo R., Souza, Thiago M., Nogueira, Christiane M., Cunha, Anna C., Rodrigues, Carlos R., Ferreira, Vitor F., de Souza, Maria C.B.V.

“…In the present article, we describe the synthesis, anti-HIV1 profile and molecular modeling evaluation of 11 oxoquinoline derivatives. In the present article,…”
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Therapeutic nanosystems for oral administration of insulin by do Carmo, Flavia A, Sathler, Plinio C, Zancan, Patricia, Rodrigues, Carlos R, Castro, Helena C, de Sousa, Valeria P, Sola-Penna, Mauro, Cabral, Lucio M

“…The treatment of Diabetes Mellitus (DM), a chronic disease, is primarily based upon administration of insulin forms to patients. Conventional subcutaneous…”
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Sulphonamide and sulphonyl-hydrazone cyclic imide derivatives: Antinociceptive activity, molecular modeling and In Silico ADMET screening by de Oliveira, Kely N., Souza, Márcia M., Sathler, Plínio Cunha, Magalhães, Uiaran O., Rodrigues, Carlos R., Castro, Helena C., Palm, Patrícia R., Sarda, Maicon, Perotto, Pablo E., Cezar, Sabrina, de Brito, Monique A., Ferreira, Ariane S. S. R., Cabral, Lúcio Mendes, Machado, Clodoaldo, Nunes, Ricardo J.

“…In this paper, we describe the antinociceptive activity, molecular modeling and in silico ADMET screening of a series of sulphonyl-hydrazone and sulphonamide…”
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