Search Results - "RODEN, Michael"

Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans by Pafili, Kalliopi, Roden, Michael

“…Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic…”
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Mechanisms of Disease: hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance by Roden, Michael

“…Hepatic steatosis is defined by an increased content of hepatocellular lipids (HCLs) and is frequently observed in insulin-resistant states including type 2…”
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Energy metabolism of white adipose tissue and insulin resistance in humans by Bódis, Kálmán, Roden, Michael

“…Background Insulin resistance not only occurs in obesity, but also in lipodystrophy. Although adipose tissue mass affects metabolic fluxes and participates in…”
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Alterations of Mitochondrial Function and Insulin Sensitivity in Human Obesity and Diabetes Mellitus by Koliaki, Chrysi, Roden, Michael

“…Mitochondrial function refers to a broad spectrum of features such as resting mitochondrial activity, (sub)maximal oxidative phosphorylation capacity (OXPHOS),…”
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The complex link between NAFLD and type 2 diabetes mellitus — mechanisms and treatments by Targher, Giovanni, Corey, Kathleen E., Byrne, Christopher D., Roden, Michael

“…Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions worldwide. NAFLD and type 2 diabetes mellitus (T2DM) are known to frequently coexist…”
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The role of mitochondria in insulin resistance and type 2 diabetes mellitus by Roden, Michael, Szendroedi, Julia, Phielix, Esther

“…This Review discusses the association between mitochondrial function and insulin sensitivity in various tissues, such as skeletal muscle, liver and heart, with…”
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Hepatic energy metabolism in human diabetes mellitus, obesity and non-alcoholic fatty liver disease by Koliaki, Chrysi, Roden, Michael

“…Alterations of hepatic mitochondrial function have been observed in states of insulin resistance and non-alcoholic fatty liver disease (NAFLD). Patients with…”
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Interorgan Metabolic Crosstalk in Human Insulin Resistance by Gancheva, Sofiya, Jelenik, Tomas, Álvarez-Hernández, Elisa, Roden, Michael

“…Excessive energy intake and reduced energy expenditure drive the development of insulin resistance and metabolic diseases such as obesity and type 2 diabetes…”
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Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms by Stirban, Alin, Gawlowski, Thomas, Roden, Michael

“…Abstract The enhanced generation and accumulation of advanced glycation endproducts (AGEs) have been linked to increased risk for macrovascular and…”
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Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors by Francque, Sven, Szabo, Gyongyi, Abdelmalek, Manal F., Byrne, Christopher D., Cusi, Kenneth, Dufour, Jean-François, Roden, Michael, Sacks, Frank, Tacke, Frank

“…The increasing epidemic of obesity worldwide is linked to serious health effects, including increased prevalence of type 2 diabetes mellitus, cardiovascular…”
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Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis by Apostolopoulou, Maria, Gordillo, Ruth, Koliaki, Chrysi, Gancheva, Sofia, Jelenik, Tomas, De Filippo, Elisabetta, Herder, Christian, Markgraf, Daniel, Jankowiak, Frank, Esposito, Irene, Schlensak, Matthias, Scherer, Philipp E, Roden, Michael

“…Insulin resistance and nonalcoholic fatty liver (NAFL) disease have been linked to several lipid metabolites in animals, but their role in humans remains…”
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NAFLD and thyroid function: pathophysiological and therapeutic considerations by Hatziagelaki, Erifili, Paschou, Stavroula A., Schön, Martin, Psaltopoulou, Theodora, Roden, Michael

“…Nonalcoholic fatty liver disease (NAFLD) is a worldwide rising challenge because of hepatic, but also extrahepatic, complications. Thyroid hormones are master…”
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Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans by Szendroedi, Julia, Yoshimura, Toru, Phielix, Esther, Koliaki, Chrysi, Marcucci, Mellissa, Zhang, Dongyan, Jelenik, Tomas, Müller, Janette, Herder, Christian, Nowotny, Peter, Shulman, Gerald I., Roden, Michael

“…Muscle insulin resistance is a key feature of obesity and type 2 diabetes and is strongly associated with increased intramyocellular lipid content and…”
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Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial by Kahl, Sabine, Gancheva, Sofiya, Straßburger, Klaus, Herder, Christian, Machann, Jürgen, Katsuyama, Hisayuki, Kabisch, Stefan, Henkel, Elena, Kopf, Stefan, Lagerpusch, Merit, Kantartzis, Konstantinos, Kupriyanova, Yuliya, Markgraf, Daniel, van Gemert, Theresa, Knebel, Birgit, Wolkersdorfer, Martin F, Kuss, Oliver, Hwang, Jong-Hee, Bornstein, Stefan R, Kasperk, Christian, Stefan, Norbert, Pfeiffer, Andreas, Birkenfeld, Andreas L, Roden, Michael

“…To evaluate whether the sodium-glucose cotransporter 2 inhibitor empagliflozin (EMPA) reduces liver fat content (LFC) in recent-onset and metabolically…”
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Early Detection of Nerve Fiber Loss by Corneal Confocal Microscopy and Skin Biopsy in Recently Diagnosed Type 2 Diabetes by ZIEGLER, Dan, PAPANAS, Nikolaos, STACHS, Oliver, GUTHOFF, Rudolf F, RODEN, Michael, ZHIVOV, Andrey, ALLGEIER, Stephan, WINTER, Karsten, ZIEGLER, Iris, BRÜGGEMANN, Jutta, STROM, Alexander, PESCHEL, Sabine, KÖHLER, Bernd

“…We sought to determine whether early nerve damage may be detected by corneal confocal microscopy (CCM), skin biopsy, and neurophysiological tests in 86…”
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Lipid-mediated muscle insulin resistance: different fat, different pathways? by Ritter, Olesja, Jelenik, Tomas, Roden, Michael

“…Increased dietary fat intake and lipolysis result in excessive lipid availability, which relates to impaired insulin sensitivity. Over the last years, several…”
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Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial by Karusheva, Yanislava, Koessler, Theresa, Strassburger, Klaus, Markgraf, Daniel, Mastrototaro, Lucia, Jelenik, Tomas, Simon, Marie-Christine, Pesta, Dominik, Zaharia, Oana-Patricia, Bódis, Kálmán, Bärenz, Felix, Schmoll, Dieter, Wolkersdorfer, Martin, Tura, Andrea, Pacini, Giovanni, Burkart, Volker, Müssig, Karsten, Szendroedi, Julia, Roden, Michael

“…Epidemiological studies have shown that increased circulating branched-chain amino acids (BCAAs) are associated with insulin resistance and type 2 diabetes…”
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Effects of Blood Flow Restriction Exercise and Possible Applications in Type 2 Diabetes by Saatmann, Nina, Zaharia, Oana-Patricia, Loenneke, Jeremy P., Roden, Michael, Pesta, Dominik H.

“…Blood flow restriction resistance training (BFRT) employs partial vascular occlusion of exercising muscles via inflation cuffs. Compared with high-load…”
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From NAFLD to MASLD: Promise and pitfalls of a new definition by Cusi, Kenneth, Younossi, Zobair, Roden, Michael

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Systematic review of reviews of intervention components associated with increased effectiveness in dietary and physical activity interventions by Greaves, Colin J, Sheppard, Kate E, Abraham, Charles, Hardeman, Wendy, Roden, Michael, Evans, Philip H, Schwarz, Peter

“…To develop more efficient programmes for promoting dietary and/or physical activity change (in order to prevent type 2 diabetes) it is critical to ensure that…”
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