Search Results - "ROBLES, HILDA VARGAS"
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Loss of cortactin causes endothelial barrier dysfunction via disturbed adrenomedullin secretion and actomyosin contractility
Published in Scientific reports (30-06-2016)“…Changes in vascular permeability occur during inflammation and the actin cytoskeleton plays a crucial role in regulating endothelial cell contacts and…”
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Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage
Published in Oxidative medicine and cellular longevity (01-01-2016)“…Inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn’s disease (CD) are multifactorial, relapsing disorders of the gastrointestinal…”
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3
The role of actin-binding proteins in the control of endothelial barrier integrity
Published in Thrombosis and haemostasis (01-01-2015)“…The endothelial barrier of the vasculature is of utmost importance for separating the blood stream from underlying tissues. This barrier is formed by tight and…”
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4
ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID‐19
Published in Journal of leukocyte biology (01-06-2022)“…Severe coronavirus disease 2019 (COVID‐19) is characterized by lung injury, cytokine storm, and increased neutrophil‐to‐lymphocyte ratio (NLR). Current…”
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Homoectoine Protects Against Colitis by Preventing a Claudin Switch in Epithelial Tight Junctions
Published in Digestive diseases and sciences (01-02-2019)“…Background Inflammatory bowel diseases (IBD) are multifactorial disorders affecting millions of people worldwide with alarmingly increasing incidences every…”
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Kidney damage after renal ablation is worsened in endothelial nitric oxide synthase (−/−) mice and improved by combined administration of L-arginine and antioxidants
Published in Nephrology (Carlton, Vic.) (01-04-2008)“…Aim Reduction in nitric oxide (NO) levels during kidney failure has been related to the reaction of NO with superoxide anions to yield peroxynitrite which…”
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7
Arpin deficiency increases actomyosin contractility and vascular permeability
Published in eLife (19-09-2024)“…Arpin was discovered as an inhibitor of the Arp2/3 complex localized at the lamellipodial tip of fibroblasts, where it regulated migration steering. Recently,…”
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Lead exposure effect on angiotensin II renal vasoconstriction
Published in Human & experimental toxicology (01-06-2007)“…Low levels of chronic lead exposure can produce hypertension and endothelial dysfunction, which could be associated with oxidative stress, changes in vascular…”
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Role of sodium/glucose cotransporter inhibition on a rat model of angiotensin II-dependent kidney damage
Published in BMC nephrology (02-08-2019)“…Renal proximal tubular sodium and glucose reabsorption are regulated by the sodium-glucose cotransporter (SGLT2). Changes in this transporter can play a role…”
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10
Role of Src and Cortactin in Pemphigus Skin Blistering
Published in Frontiers in immunology (04-04-2019)“…Autoantibodies against desmoglein (Dsg) 1 and Dsg3 primarily cause blister formation in the autoimmune disease pemphigus vulgaris (PV). Src was proposed to…”
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11
HS1 deficiency protects against sepsis by attenuating neutrophil-inflicted lung damage
Published in European journal of cell biology (01-04-2022)“…Sepsis remains an important health problem worldwide due to inefficient treatments often resulting in multi-organ failure. Neutrophil recruitment is critical…”
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12
Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice
Published in Oxidative medicine and cellular longevity (01-01-2015)“…Obesity is a worldwide epidemic that is characterized not only by excessive fat deposition but also by systemic microinflammation, high oxidative stress, and…”
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13
Hindlimb claudication reflects impaired nitric oxide-dependent revascularization after ischemia
Published in Vascular pharmacology (01-01-2007)“…Abstract Although vascular remodeling is important in preventing tissue damage and restoring muscle function, there is no evidence of a relationship between…”
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14
Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published in Journal of visualized experiments (05-01-2017)“…Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic relapsing disorders of the intestines. They cause severe…”
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15
The role of nitric oxide in the post-ischemic revascularization process
Published in Pharmacology & therapeutics (Oxford) (01-11-2006)“…Following arterial occlusion, blood vessels respond by sprouting new capillaries (i.e. angiogenesis) and by growing and remodelling pre-existing arterioles…”
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16
Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms
Published in Tissue barriers (01-12-2013)“…The intestinal epithelium forms a stable barrier protecting underlying tissues from pathogens in the gut lumen. This is achieved by specialized integral…”
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17
Oxidative Stress-Dependent Coronary Endothelial Dysfunction in Obese Mice
Published in PloS one (18-09-2015)“…Obesity is involved in several cardiovascular diseases including coronary artery disease and endothelial dysfunction. Endothelial Endothelium vasodilator and…”
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The Actin-Binding Protein Cortactin Promotes Sepsis Severity by Supporting Excessive Neutrophil Infiltration into the Lung
Published in Biomedicines (28-04-2022)“…Sepsis is a systemic infection that can lead to multi-organ failure. It is characterised by an uncontrolled immune response with massive neutrophil influx into…”
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The Arp2/3 Inhibitory Protein Arpin Is Required for Intestinal Epithelial Barrier Integrity
Published in Frontiers in cell and developmental biology (03-05-2021)“…The intestinal epithelial barrier (IEB) depends on stable interepithelial protein complexes such as tight junctions (TJ), adherens junctions (AJ), and the…”
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20
Association between the levels of circulating adhesion molecules and biopterins in type-2 diabetic normotensive patients adhesion molecules and biopterins
Published in Endocrine, metabolic & immune disorders drug targets (01-09-2012)“…Endothelial dysfunction is a common feature in type-2 diabetic patients and is associated with inflammation, increased levels of circulating soluble adhesion…”
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