Search Results - "ROBINSON, M. O"

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells by Zhang, X, Mar, V, Zhou, W, Harrington, L, Robinson, M O

“…Despite a strong correlation between telomerase activity and malignancy, the outcome of telomerase inhibition in human tumor cells has not been examined. Here,…”
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A Mammalian Telomerase-Associated Protein by Harrington, Lea, McPhail, Timothy, Mar, Vernon, Zhou, Wen, Oulton, Rena, Program, Amgen EST, Bass, Mike B., Arruda, Isabel, Robinson, Murray O.

“…The telomerase ribonucleoprotein catalyzes the addition of new telomeres onto chromosome ends. A gene encoding a mammalian telomerase homolog called TP1…”
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The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo by Liu, Y, Snow, B.E, Hande, M.P, Yeung, D, Erdmann, N.J, Wakeham, A, Itie, A, Siderovski, D.P, Lansdorp, P.M, Robinson, M.O, Harrington, L

“…Mammalian telomerase is essential for the maintenance of telomere length [1–5]. Its catalytic core comprises a reverse transcriptase component (TERT) and an…”
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Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding by Beattie, T L, Zhou, W, Robinson, M O, Harrington, L

“…The minimal, active core of human telomerase is postulated to contain two components, the telomerase RNA hTER and the telomerase reverse transcriptase hTERT…”
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Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo by Liu, Yie, Snow, Bryan E., Hande, M. Prakash, Baerlocher, Gabriela, Kickhoefer, Valerie A., Yeung, David, Wakeham, Andrew, Itie, Annick, Siderovski, David P., Lansdorp, Peter M., Robinson, Murray O., Harrington, Lea

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Transcriptional Regulatory Regions of Testis-Specific PGK2 Defined in Transgenic Mice by Robinson, Murray O., McCarrey, John R., Simon, Melvin I.

“…The gene encoding testis-specific phosphoglycerate kinase 2 (PGK; ATP:3-phospho-D-glycerate 1-phosphotransferase, EC 2.7.2.3) is expressed only in meiotic and…”
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E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes by Guy, Chantale T., Zhou, Wen, Kaufman, Stephen, Robinson, Murray O.

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Measurement by quantitative PCR of changes in HPRT, PGK-1, PGK-2, APRT, MTase, and Zfy gene transcripts during mouse spermatogenesis by SINGER-SAM, J, ROBINSON, M. O, BELLVE, A. R, SIMON, M. L, RIGGS, A. S

“…A reverse transcriptase-polymerase chain reaction assay (RT-PCR) was used quantitatively to measure accumulated levels of RNA transcripts in total mouse RNAs…”
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Reconstitution of human telomerase activity in vitro by Beattie, Tara L., Zhou, Wen, Robinson, Murray O., Harrington, Lea

“…Telomerase is a ribonucleoprotein enzyme complex that adds single-stranded telomere DNA to chromosome ends [1]. The RNA component of telomerase contains the…”
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Human telomerase contains evolutionarily conserved catalytic and structural subunits by Harrington, L, Zhou, W, McPhail, T, Oulton, R, Yeung, D S, Mar, V, Bass, M B, Robinson, M O

“…We have cloned and characterized a human gene encoding TP2 (telomerase-associated protein 2), a protein with similarity to reverse transcriptases and the…”
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Functional Multimerization of the Human Telomerase Reverse Transcriptase by Beattie, Tara L., Zhou, Wen, Robinson, Murray O., Harrington, Lea

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Determining transcript number using the polymerase chain reaction : Pgk-2, mP2, and PGK-2 transgene mRNA levels during spermatogenesis by ROBINSON, M. O, SIMON, M. I

“…We describe a technique that uses reverse transcription and the polymerase chain reaction (pcr) to rapidly quantitate numbers of specific mRNA transcripts from…”
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The hTERTα Splice Variant is a Dominant Negative Inhibitor of Telomerase Activity by Colgin, Lorel M., Wilkinso, Christen, Englezou, Anna, Kilian, Andrzej, Robinson, Murray O., Reddel, Roger R.

“…The telomerase catalytic subunit (hTERT) is an essential component of the holoenzyme complex that adds telomeric repeats to the ends of human chromosomes…”
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Vaults and Telomerase Share a Common Subunit, TEP1 by Kickhoefer, Valerie A., Stephen, Andrew G., Harrington, Lea, Robinson, Murray O., Rome, Leonard H.

“…Vaults are large cytoplasmic ribonucleoprotein complexes of undetermined function. Mammalian vaults have two high molecular mass proteins of 193 and 240 kDa…”
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The tsA58 Simian Virus 40 Large Tumor Antigen Disrupts Megakaryocyte Differentiation in Transgenic Mice by Robinson, Murray O., Zhou, Wen, Hokom, Martha, Danilenko, Dimitry M., Hsu, Rou-Yin, Atherton, Ruth E., Xu, Weilong, Mu, Sharon, Christiaan J. M. Saris, Swift, Susan, Elliot, Gary, Del Castillo, Juan, Hunt, Pamela, Bosselman, Robert A.

“…Thrombocytopenia is a condition of multiple etiologies affecting the megakaryocyte lineage. To perturb this lineage in transgenic mice, the tsA58 mutation of…”
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Relationships between HMOs and mental health providers by Robinson, M O

“…Health maintenance organizations (HMOs) have had a great impact on traditional health delivery systems. The author discusses this impact with regard to the…”
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Transgenic Mice Overexpressing Human c-mpl Ligand Exhibit Chronic Thrombocytosis and Display Enhanced Recovery From 5-Fluorouracil or Antiplatelet Serum Treatment by Zhou, Wen, Toombs, Christopher F., Zou, Tong, Guo, Jane, Robinson, Murray O.

“…The consequences of long-term in vivo expression of human c-mpl ligand in a mouse model were examined. Transgenic mice expressing the human full-length cDNA in…”
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Telomerase and cancer by Robinson, M O

“…The past few years have brought a flood of new information to the telomerase field. The identification of multiple components of both the telomere and…”
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Transgenic mice overexpressing human c-mpl ligand exhibit chronic thrombocytosis and display enhanced recovery from 5-fluorouracil or antiplatelet serum treatment by ZHOU, Y. W, TOOMBS, C. F, ZOU, T, GUO, J, ROBINSON, M. O

“…The consequences of long-term in vivo expression of human c-mpl ligand in a mouse model were examined. Transgenic mice expressing the human full-length cDNA in…”
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Bactericidal capacity of newborn phagocytes against group B beta-hemolytic streptococci by Becker, I D, Robinson, O M, Bazán, T S, López-Osuna, M, Kretschmer, R R

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